Results 1 to 10 of about 27,474 (197)

The expression of Mutl Protein Homolog 1 (MLH1) and Muts Homolog 2 (MSH2) in colorectal carcinoma: An immunohistochemical study

Indian Journal of Pathology and Microbiology
Background: The development of colorectal carcinoma is a complicated multistep process that involves the accumulation of mutations in tumor suppressor genes and oncogenes.
Eshita Garg, Manisha Sharma, Manas Madan, Gurleen Kaur, Karamjit S Gill, Ishaan Khanna   +5 more
doaj   +3 more sources

Promoter methylation of the hMLH1 gene and protein expression of human mutL homolog 1 and human mutS homolog 2 in resected esophageal squamous cell carcinoma [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 2005
Aberrant expression of mismatch repair genes, such as human mutL homolog 1 (hMLH1) and human mutS homolog 2 (hMSH2), are common in some human cancers, and promoter methylation is believed to inactivate expression of hMLH1. We investigated whether promoter methylation is involved in loss of hMLH1 protein and whether aberrant expression of hMLH1 and ...
Ching, Tzao, Han-Sui, Hsu, Guang-Huan, Sun, Hsiao-Lei, Lai, Hsiou-Lei, Lai, Yi-Ching, Wang, Ho-Jui, Tung, Cheng-Ping, Yu, Yeung-Leung, Cheng, Shih-Chun, Lee   +9 more
openaire   +3 more sources

Clinical significance of chromodomain helicase/ATPase DNA binding protein 1‑like and human mutL homolog�1 gene expression in cholangiocarcinoma

Oncology Letters, 2018
Cholangiocarcinoma is a highly malignant form of gastrointestinal cancer with an unfavorable prognosis. The novel oncogene chromodomain helicase/ATPase DNA binding protein 1-like (CHD1L) has been confirmed to serve a vital role in numerous types of cancer, including liver cancer.
Hua, Jingwen, Li, Shiniao, Huang, Changwen   +2 more
openaire   +4 more sources

Mismatch repair proteins play a role in ATR activation upon temozolomide treatment in MGMT-methylated glioblastoma

Scientific Reports, 2022
The methylation status of the O6-methylguanine methyltransferase (MGMT) gene promoter has been widely accepted as a prognostic biomarker for treatment with the alkylator, temozolomide (TMZ). In the absence of promoter methylation, the MGMT enzyme removes
Sachita Ganesa, Amrita Sule, Ranjini K. Sundaram, Ranjit S. Bindra   +3 more
doaj   +2 more sources

Diagnosis and functional prediction of microbial markers in tumor tissues of sporadic colorectal cancer patients associated with the MLH1 protein phenotype

Frontiers in Oncology, 2023
ObjectiveMost patients with sporadic colorectal cancer (SCRC) develop microsatellite instability because of defects in mismatch repair (MMR). Moreover, the gut microbiome plays a vital role in the pathogenesis of SCRC.
Anchao Zhu, Anchao Zhu, Yingying Liu, Zongmin Li, Ying He, Lijing Bai, Youtian Wu, Yuying Zhang, Ying Huang, Ping Jiang   +9 more
doaj   +2 more sources

Targeting mitochondrial DNA polymerase gamma for selective inhibition of MLH1 deficient colon cancer growth.

PLoS ONE, 2022
Synthetic lethality in DNA repair pathways is an important strategy for the selective treatment of cancer cells without harming healthy cells and developing cancer-specific drugs. The synthetic lethal interaction between the mismatch repair (MMR) protein,
Berna Somuncu, Aysegul Ekmekcioglu, Fatma Merve Antmen, Tugce Ertuzun, Emre Deniz, Nazli Keskin, Joon Park, Ilgu Ece Yazici, Busra Simsek, Batu Erman, Whitney Yin, Burak Erman, Meltem Muftuoglu   +12 more
doaj   +4 more sources

Mismatch Repair Protein Deficiency and Its Relationship with Clinicopathological Factors in Endometrial Cancer: A Retrospective Study. [PDF]

J Cancer
Background: The present study aimed to determine the frequency of mismatch repair (MMR) protein expression loss, as identified using immunohistochemistry (IHC), in tumor cells of endometrial cancer patients and the potential associations between this ...
Aytekin O, Cesur N, Gozel S, Karsli SE, Tokalioglu AA, Kilic F, Cuylan ZF, Selcuk I, Comert GK, Erdogan F, Turan T.   +10 more
europepmc   +2 more sources

Expression and prognostic significance of MLH1 and GPRC5C in resectable hepatocellular carcinoma [PDF]

BMC Cancer
Background It has recently been shown that mut-L homolog 1 (MLH1), frequently lost in cancer initiation and progression, inhibited pancreatic cancer metastatic potential by downregulating G-protein coupled receptor C5C (GPRC5C). However, their expression
Jun Lu, Lei Li, Qing Chen, Bingqi Li, Siqian Ren, Meng Yuan, Meng Meng, Jian Lei, Yuntao Bing, Hangyan Wang, Zhaolai Ma, Dianrong Xiu, Chunhui Yuan   +12 more
doaj   +2 more sources

Prevalence of DNA Mismatch Repair Deficiencies in Multiple Solid Tumor Types in China. [PDF]

J Evid Based Med
ABSTRACT Aim Microsatellite instability (MSI) as a result of deficient deoxyribonucleic acid (DNA) mismatch repair (dMMR) is a key contributor to the development of tumors with a high mutation rate and cancer‐specific neoantigens. dMMR identification can be beneficial for selection of immune checkpoint inhibitor (ICI) therapy‐eligible patients.
Shi X, Yang X, Yun J, Fan X, Hou Y, Wang Z, Li P, Chen J, Jiang D, Chen L, Wang Y, Ramar R, Wong MT, Poon SL, Liang Z.   +14 more
europepmc   +2 more sources

Successful Identification and Treatment of Cancer of Unknown Primary Originating From Gastric Cancer Using Comprehensive Genomic Profiling and Immune Checkpoint Inhibitor Therapy: A Case Report. [PDF]

Cancer Rep (Hoboken)
ABSTRACT Background Cancer of unknown primary (CUP) is a challenging malignancy characterized by metastatic tumors with an unidentified primary site, even after extensive pathological and radiographic evaluation. Recent advancements in gene expression profiling and comprehensive genomic profiling (CGP) using next‐generation sequencing (NGS) have ...
Sasaki T, Yuzawa S, Tanabe H, Ono Y, Takahashi K, Ando K, Ueno N, Kashima S, Moriichi K, Tanino M, Mizukami Y, Fujiya M.   +11 more
europepmc   +2 more sources