Results 11 to 20 of about 27,474 (197)

DNA Methylation in Ovarian and Endometrial Cancers: Predictive and Mechanistic Roles in PARP Inhibitor and ICI Response. [PDF]

Cancer Sci
Cancer treatment is shifting from an organ‐based framework to one driven by biological phenotypes, and DNA methylation is increasingly recognized as an important factor that governs tumor behavior beyond genetic mutations. In gynecologic cancers, BRCA1 and MLH1 promoter methylation–associated homologous recombination deficiency and mismatch repair ...
Kitamura S, Taguchi A, Tamai K, Yamamoto Y, Duong AQ, Yoshimoto D, Mori A, Ishizaka A, Tsuchimochi S, Sone K, Kawazu M, Oda K, Hirota Y.   +12 more
europepmc   +2 more sources

Multi-omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine. [PDF]

Mol Oncol
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Concetti L, Scimeca M, Bischof J, Woodsmith J, Agostini M, Fiorani C, Shi Y, Candi E, Melino G, Mauriello A, Sica GS.   +10 more
europepmc   +2 more sources

A rare case of colonic adenocarcinoma in a pediatric patient. [PDF]

JPGN Rep
Abstract Lynch syndrome (LS) is an autosomal dominant condition caused by a loss of function in the deoxyribonucleic acid mismatch repair system. This case report presents a 17‐year‐old male with abdominal pain, weight loss, and anemia who was diagnosed with LS‐associated adenocarcinoma of the colon in the setting of a mutS homolog 6 genetic mutation ...
Kaba C, Chatman K, Hames N, Velazquez Vega JE, Bashaw H.   +4 more
europepmc   +2 more sources

Pulmonary Tumor Thrombotic Microangiopathy Associated With Gastric Cancer: Clinical Characteristics and Outcomes. [PDF]

J Gastric Cancer
Purpose Pulmonary tumor thrombotic microangiopathy (PTTM) is a fatal complication of gastric cancer (GC). This study aimed to evaluate the clinical characteristics, outcomes, and immunohistochemical profiles of patients with GC-induced PTTM.
Kim TS, Ahn S, Chang SA, Lim SH, Min BH, Min YW, Lee H, Rhee PL, Kim JJ, Lee JH.   +9 more
europepmc   +2 more sources

The CtIP-CtBP1/2-HDAC1-AP1 transcriptional complex is required for the transrepression of DNA damage modulators in the pathogenesis of osteosarcoma

Translational Oncology, 2022
Most tumors, including osteosarcomas, have deficiencies in DNA damage repair. However, the regulatory mechanisms underlying dysregulation of DNA damage repair genes are still being investigated.
Xun Chen, Qian Zhang, Xiaoqian Dang, Jinzhu Fan, Tao Song, Zhong Li, Ning Duan, Wentao Zhang   +7 more
doaj   +1 more source

Expression of PD-L1 in Microsatellite Instability High Tumours: A Retrospective Study [PDF]

Journal of Clinical and Diagnostic Research, 2023
Introduction: Microsatellite Instability (MSI) is the hallmark of Lynch syndrome/Constitutional Mismatch Repair Deficiency (CMMRD) and is also found in many sporadic cancers like colorectal cancer, endometrial, gastric, small intestine, urothelial ...
Dinisha Einstien, Gayathri Devi Thanigaimani, KS Mouleeswaran, A Prathiba, G Sarumathy, John Vergilin   +5 more
doaj   +1 more source

Mlh2 is an accessory factor for DNA mismatch repair in Saccharomyces cerevisiae. [PDF]

, 2014
In Saccharomyces cerevisiae, the essential mismatch repair (MMR) endonuclease Mlh1-Pms1 forms foci promoted by Msh2-Msh6 or Msh2-Msh3 in response to mispaired bases. Here we analyzed the Mlh1-Mlh2 complex, whose role in MMR has been unclear.
Bowen, Nikki, Campbell, Christopher S, Desai, Arshad, Gries, Kerstin, Hombauer, Hans, Kolodner, Richard D, Putnam, Christopher D, Srivatsan, Anjana   +7 more
core   +6 more sources

Identification of Driving ALK Fusion Genes and Genomic Landscape of Medullary Thyroid Cancer. [PDF]

PLoS Genetics, 2015
The genetic landscape of medullary thyroid cancer (MTC) is not yet fully understood, although some oncogenic mutations have been identified. To explore genetic profiles of MTCs, formalin-fixed, paraffin-embedded tumor tissues from MTC patients were ...
Jun Ho Ji, Young Lyun Oh, Mineui Hong, Jae Won Yun, Hyun-Woo Lee, DeokGeun Kim, Yongick Ji, Duk-Hwan Kim, Woong-Yang Park, Hyun-Tae Shin, Kyoung-Mee Kim, Myung-Ju Ahn, Keunchil Park, Jong-Mu Sun   +13 more
doaj   +1 more source

Identification of a novel pathogenic MLH1 mutation and recommended genetic screening strategy: An investigation of three Chinese Lynch syndrome pedigrees

Molecular Genetics & Genomic Medicine, 2020
Background Lynch syndrome (LS) is an autosomal‐dominant disorder that increases the risk of many cancers. The genetic basis of LS is germline mutations in DNA mismatch repair genes.
Fan Li, Yunwei Xia, Guoguang Wang, Chaoyang Tang, Tian Zhan, Jian Shen, Jianping Zhang   +6 more
doaj   +1 more source

Recombination homeostasis of meiosis during spermatogenesis under nicotine treatment [PDF]

Archives of Biological Sciences, 2018
Cigarette smoking can affect male fertility via the quality of semen. To explore the effects of nicotine, a major component of cigarettes, on meiotic recombination during spermatogenesis, C57BL/6J male mice were injected with nicotine at a dosage of 0.2 ...
Zhai Jingli, Yuan Qingqing, Yang Tianqi, Zhao Xianglong, Zhang Meixing, Zhang Dong, Xu Wangjie, Qiao Zhongdong   +7 more
doaj   +1 more source