Results 21 to 30 of about 27,474 (197)

Genetic pathways, prevention, and treatment of sporadic colorectal cancer [PDF]

open access: yes, 2014
Epithelial cancer of the colon and rectum, also known as colorectal cancer (CRC), results from a progressive accumulation of genetic and epigenetic alterations that lead to uncontrolled growth of colonocytes, the cells lining the colon and rectum. CRC is
Imperiale, Thomas F.   +4 more
core   +6 more sources

Overexpression of MutL homolog 1 and MutS homolog 2 proteins have reversed prognostic implications for stage I–II colon cancer patients

open access: yesBiomedical Journal, 2017
The outcome of colon cancer patients without lymph node metastasis is heterogeneous. Searching for new prognostic markers is warranted.One hundred twenty stage I-II colon cancer patients who received complete surgical excision during 1995-2004 were selected for this biomarker study.
Shih-Chiang Huang   +7 more
openaire   +3 more sources

Phage inducible islands in the gram-positive cocci [PDF]

open access: yes, 2016
The SaPIs are a cohesive subfamily of extremely common phage-inducible chromosomal islands (PICIs) that reside quiescently at specific att sites in the staphylococcal chromosome and are induced by helper phages to excise and replicate.
A Bolotin   +47 more
core   +1 more source

Endonuclease activities of MutLα and its homologs in DNA mismatch repair. [PDF]

open access: yes, 2016
MutLα is a key component of the DNA mismatch repair system in eukaryotes. The DNA mismatch repair system has several genetic stabilization functions. Of these functions, DNA mismatch repair is the major one.
Kadyrov, Farid A, Kadyrova, Lyudmila Y
core   +2 more sources

MLH1 Deficiency Induces Cetuximab Resistance in Colon Cancer via Her‐2/PI3K/AKT Signaling

open access: yesAdvanced Science, 2020
The rapid onset of resistance to cetuximab (CTX) limits its clinical utility in colorectal cancer (CRC) patients. This study aims to understand a potential role of mismatch repair gene mutL homolog 1 (MLH1) in CTX response. Functional analysis of MLH1 in
Ying Han   +13 more
doaj   +1 more source

The Prediction of the Expected Current Selection Coefficient of Single Nucleotide Polymorphism Associated with Holstein Milk Yield, Fat and Protein Contents [PDF]

open access: yesAsian-Australasian Journal of Animal Sciences, 2016
Milk-related traits (milk yield, fat and protein) have been crucial to selection of Holstein. It is essential to find the current selection trends of Holstein. Despite this, uncovering the current trends of selection have been ignored in previous studies.
Young-Sup Lee   +6 more
doaj   +1 more source

Factors modifying the risk for developing acute skin toxicity after whole-breast intensity modulated radiotherapy [PDF]

open access: yes, 2014
Background: After breast-conserving radiation therapy most patients experience acute skin toxicity to some degree. This may impair patients' quality of life, cause pain and discomfort. In this study, we investigated treatment and patient-related factors,
De Langhe, Sofie   +9 more
core   +2 more sources

A Computational Approach to Estimating Nondisjunction Frequency in Saccharomyces cerevisiae. [PDF]

open access: yes, 2016
Errors segregating homologous chromosomes during meiosis result in aneuploid gametes and are the largest contributing factor to birth defects and spontaneous abortions in humans.
Burgess, Sean M, Chu, Daniel B
core   +3 more sources

Werner Syndrome Helicase Is Required for the Survival of Cancer Cells with Microsatellite Instability

open access: yesiScience, 2019
Summary: Werner syndrome protein (WRN) is a RecQ enzyme involved in the maintenance of genome integrity. Germline loss-of-function mutations in WRN led to premature aging and predisposition to cancer.
Lorn Kategaya   +3 more
doaj   +1 more source

Human MutL homolog 1 immunoexpression in oral leukoplakia and oral squamous cell carcinoma: A prospective study in Indian population

open access: yesJournal of Oral and Maxillofacial Pathology, 2016
Background: Mammalian mismatch repair system is responsible for maintaining genomic stability during repeated duplications, and human MutL homolog 1 (hMLH1) protein constitutes an important part of it.
N. Chaudhari   +3 more
semanticscholar   +1 more source

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