Results 61 to 70 of about 27,474 (197)

Unlocking nitrogen regulation: structural insights into the NifL‐NifA complex and prospects for engineered diazotrophs

The FEBS Journal, EarlyView.
The urgent need for sustainable agriculture places biological nitrogen fixation at the forefront of current biotechnological research. Plant growth‐promoting rhizobacteria play crucial roles in agriculture by enhancing nutrient absorption, regulating hormonal balance, and providing reduced nitrogen to plants. Among these, diazotrophic bacteria, such as
Edileusa Cristina Marques Gerhardt, Khaled A. Selim   +1 more
wiley   +1 more source

Structure of the Endonuclease Domain of MutL: Unlicensed to Cut [PDF]

, 2010
DNA mismatch repair corrects errors that have escaped polymerase proofreading, increasing replication fidelity 100- to 1000-fold in organisms ranging from bacteria to humans.
Chung, Yu Seon, Friedhoff, Peter, Guarne, Alba, Klocko, Andrew D., Lorenowicz, Jessica J., Mitchell, Ryan R., Modrich, Paul, Pillon, Monica C., Simmons, Lyle A., Uckelmann, Michael, Walker, Graham C.   +10 more
core   +1 more source

Exploring the Key Role of Nanotechnology on Intratumoral Microbiome Modulation for Cancer Immunotherapy

MedComm – Biomaterials and Applications, Volume 5, Issue 1, March 2026.
The review provides a comprehensive analysis of microbiome‐mediated oncogenic mechanisms in various cancers, emphasizing the unique therapeutic strategies facilitated by nanotechnology. It aims to fill this gap by systematically reviewing nanotechnology‐driven strategies for microbiome elimination, with a focus on their ability to improve the cold TME ...
Yumei Gan, Yan Zhang, Xia Dong, Feng Lv
wiley   +1 more source

DNA repair in cancer: emerging targets for personalized therapy [PDF]

, 2014
Genomic deoxyribonucleic acid (DNA) is under constant threat from endogenous and exogenous DNA damaging agents. Mammalian cells have evolved highly conserved DNA repair machinery to process DNA damage and maintain genomic integrity.
Abbotts, Rachel, Madhusudan, Srinivasan, Thompson, Nicola   +2 more
core   +3 more sources

Depleted-MLH1 Expression Predicts Prognosis and Immunotherapeutic Efficacy in Uterine Corpus Endometrial Cancer: An In Silico Approach

BioMedInformatics
Uterine corpus endometrial carcinoma (UCEC) poses significant clinical challenges due to its high incidence and poor prognosis, exacerbated by the lack of effective screening methods.
Tesfaye Wolde, Jing Huang, Peng Huang, Vijay Pandey, Peiwu Qin   +4 more
doaj   +1 more source

Alterations of DNA damage repair in cancer: from mechanisms to applications

Annals of Translational Medicine, 2020
DNA damage repair (DDR) pathways are essential to ensure the accurate transmission of genetic material. However, different endogenous and exogenous factors challenge genomic integrity. Mechanisms involved in the alterations of DDR pathways mainly include
Minlin Jiang, Keyi Jia, Lei Wang, Wei Li, Bin Chen, Yu Liu, Hao Wang, Sha Zhao, Yayi He, Caicun Zhou   +9 more
semanticscholar   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

MSH3 protein expression and nodal status in MLH1-deficient colorectal cancers. [PDF]

, 2012
View the MathML source: Colorectal tumors manifesting high-frequency microsatellite instability (MSI-H) develop genetically as a consequence of mutations in genes harboring repetitive DNA sequences.
Bianchi, P, Capella, C, Celesti, G, Chiaravalli, Am, Delconte, G, Di Caro, G, Jung, B, Laghi, L, Malesci, A., Pedroni, Monica, Ponz De Leon, Maurizio   +10 more
core   +1 more source

Molecular classification of microsatellite-instable colorectal cancers reveals distinct predictors of immunotherapy response

ESMO Gastrointestinal Oncology
Microsatellite-instable (MSI) tumours constitute one-fifth of colorectal cancers (CRCs). However, the MSI CRCs display substantial tumour microenvironment (TME) heterogeneity and variable responses to immunotherapy, necessitating a refined classification
C. Lin, T. Luo, M. Wu, F. Li, L. Nunes, A. Mezheyeuski, K. Hammarström, A. Isaksson, I. Ljuslinder, M. Uhlén, R. Palmqvist, S. Zhu, B. Glimelius, K. Wu, T. Sjöblom   +14 more
doaj   +1 more source

A Clinical Guidance for the Management of Patients With Hepatoid Adenocarcinoma and A Case Series

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Hepatoid adenocarcinoma (HAC) is a rare extrahepatic tumor of non‐germ cell origin that morphologically resembles hepatocellular carcinoma (HCC). HAC has a propensity to metastasize to the liver and therefore may be mistaken for HCC. There is a lack of standardized treatment protocols, and further studies are needed to evaluate the benefit of ...
Christina Liava, Sudhakar Venkatesh, Michael S. Torbenson, Patrick S. Kamath, Moira Hilscher   +4 more
wiley   +1 more source