Results 41 to 50 of about 26,541 (200)

MEX3A impairs DNA mismatch repair signaling and mediates acquired temozolomide resistance in glioblastoma.

Cancer Research, 2022
MutS protein homolog 2 (MSH2) is a key element involved in the DNA mismatch repair system, which is responsible for recognizing and repairing mispaired bases.
T. Gan, Yan Wang, Manyi Xie, Qiang Wang, Saisai Zhao, Peng Wang, Qin-dong Shi, Xuanchen Qian, Faan Miao, Z.W. Shen, Er Nie   +10 more
semanticscholar   +1 more source

Clinical exome performance for reporting secondary genetic findings. [PDF]

, 2014
BACKGROUND : Reporting clinically actionable incidental genetic findings in the course of clinical exome testing is recommended by the American College of Medical Genet- ics and Genomics (ACMG).
Clark, P, Fortina, Paolo, Kricka, Lj, Londin, E, Park, J. Y., Park, Jy, Sponziello, Marialuisa   +6 more
core   +1 more source

Mismatch Repair Deficient (dMMR) Colorectal Carcinoma in a Pakistani Cohort: Association With Clinical and Pathological Parameters

Cureus, 2023
Introduction Microsatellite instability (MSI) is an important pathway in colorectal carcinoma (CRC) pathogenesis. MSI occurs due to mutations in mismatch repair (MMR) genes that include MutL protein homolog 1 (MLH1), postmeiotic segregation increased 2 ...
A. Hashmi, Ummara Bukhari, Ramish Rizwan, Faiza Faisal, Ravi Kumar, U. Malik, Shamail Zia, Abdur Rahim Khan, Sunder Sham, M. Irfan   +9 more
semanticscholar   +1 more source

Monosodium glutamate-induced alterations in MMR protein expression: A potential mechanism linking diet and colorectal cancer

Gastroenterology & Endoscopy
Background: Defective mismatch repair (MMR) proteins activate the microsatellite instability (MSI) pathway, contributing to colon carcinogenesis. Monosodium glutamate (MSG), a widely used flavor enhancer, has been implicated in colorectal cancer (CRC ...
Meenakshi Sundari Rajendran, Rajkumar Prabhakaran, Padma Malini Ravi   +2 more
doaj   +1 more source

Ataxia Telangiectasia Mutated and MSH2 Control Blunt DNA End Joining in Ig Class Switch Recombination.

Journal of Immunology, 2023
Class-switch recombination (CSR) produces secondary Ig isotypes and requires activation-induced cytidine deaminase (AID)-dependent DNA deamination of intronic switch regions within the IgH (Igh) gene locus.
Emily Sible, Mary Attaway, Giuseppe Fiorica, Genesis Michel, J. Chaudhuri, B. Vuong   +5 more
semanticscholar   +1 more source

Comparison of Microsatellite Instability (MSI) and Microsatellite Stable (MSS) Invasive Breast Carcinoma Cases In Terms Of Neoadjuvant Chemotherapy Response, ER/PR Status, CerbB2, and Ki-67

İstanbul Medical Journal
Introduction: Microsatellite instability (MSI) is a well-established biomarker in certain malignancies; however, its prognostic and predictive role in breast cancer remains unclear. This study aimed to compare invasive breast carcinoma cases with MSI and
Özgecan Gündoğar, Sibel Bektaş, Emine Yıldırım, Merve Cin, Selçuk Cin, Canan Kelten Talu   +5 more
doaj   +1 more source

Accuracy of four mononucleotide-repeat markers for the identification of DNA mismatch-repair deficiency in solid tumors

Journal of Translational Medicine, 2018
Background To screen tumors with microsatellite instability (MSI) arising due to DNA mismatch repair deficiency (dMMR), a panel of five quasi-monomorphic mononucleotide-repeat markers amplified in a multiplex PCR (Pentaplex) are commonly used.
Yuko Takehara, Takeshi Nagasaka, Akihiro Nyuya, Tomoko Haruma, Junko Haraga, Yoshiko Mori, Keiichiro Nakamura, Toshiyoshi Fujiwara, C. Richard Boland, Ajay Goel   +9 more
doaj   +1 more source

MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death [PDF]

, 2014
p53-regulated caspase-independent cell death has been implicated in suppression of tumorigenesis, however, the regulating mechanisms are poorly understood.
Leon, Julio, Nakabeppu, Yusaku, Oka, Sugako, Sakumi, Kunihiko, Tsuchimoto, Daisuke, 中別府, 雄作, 作見, 邦彦, 土本, 大介, 岡, 素雅子   +8 more
core   +1 more source

Alterations of DNA damage repair in cancer: from mechanisms to applications

Annals of Translational Medicine, 2020
DNA damage repair (DDR) pathways are essential to ensure the accurate transmission of genetic material. However, different endogenous and exogenous factors challenge genomic integrity. Mechanisms involved in the alterations of DDR pathways mainly include
Minlin Jiang, Keyi Jia, Lei Wang, Wei Li, Bin Chen, Yu Liu, Hao Wang, Sha Zhao, Yayi He, Caicun Zhou   +9 more
semanticscholar   +1 more source

Clinical Implication of DNA Damage Response Genes in Advanced Gastric Cancer Stage IV and Recurrent Gastric Cancer Patients After Gastrectomy Treated Palliative Chemotherapy

Journal of Cancer, 2023
Purpose: This study aimed to investigate the relationship between DNA damage response (DDR)-related protein expression and the clinical outcomes of patients with gastric cancer stage IV and recurrent advanced gastric cancer patients after gastrectomy ...
J. E. Kim, Song-Ee Park, Heejin Kim, I. Hwang   +3 more
semanticscholar   +1 more source