Results 21 to 30 of about 77,428 (296)

Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis

Disease Models & Mechanisms, 2015
Cost-effective animal models that accurately reflect the pathological progression of pulmonary tuberculosis are needed to screen and evaluate novel tuberculosis drugs and drug regimens.
Scott M. Irwin, Emily Driver, Edward Lyon, Christopher Schrupp, Gavin Ryan, Mercedes Gonzalez-Juarrero, Randall J. Basaraba, Eric L. Nuermberger, Anne J. Lenaerts   +8 more
doaj   +1 more source

Expression of in vivo biotinylated recombinant antigens SAG1 and SAG2A from Toxoplasma gondii for improved seroepidemiological bead-based multiplex assays

BMC Biotechnology, 2020
Background Few bead-based multiplex assays have been described that detect antibodies against the protozoan parasite Toxoplasma gondii in large-scale seroepidemiological surveys. Moreover, each multiplex assay has specific variations or limitations, such
Sandra Klein, Daniel Stern, Frank Seeber
doaj   +1 more source

The Orphan Response Regulator Rv3143 Modulates the Activity of the NADH Dehydrogenase Complex (Nuo) in Mycobacterium tuberculosis via Protein–Protein Interactions

Frontiers in Cellular and Infection Microbiology, 2022
Two-component signal transduction systems enable mycobacterial cells to quickly adapt and adequately respond to adverse environmental conditions encountered at various stages of host infection.
Renata Płocińska, Karolina Wasik, Przemysław Płociński, Przemysław Płociński, Ewelina Lechowicz, Magdalena Antczak, Ewelina Błaszczyk, Bożena Dziadek, Marcin Słomka, Anna Rumijowska-Galewicz, Jarosław Dziadek   +10 more
doaj   +1 more source

Of Microsoft and Mycobacteria [PDF]

Canadian Journal of Infectious Diseases and Medical Microbiology, 2001
Bill Gates should have run for President of the United States. Not only would he have been a candidate with some legitimate claim to the Internet, but his call for a major increase in funding for new defence systems would have been supported by the general public, both at home and abroad.
openaire   +3 more sources

From Entry to Early Dissemination—Toxoplasma gondii's Initial Encounter With Its Host

Frontiers in Cellular and Infection Microbiology, 2019
Toxoplasma gondii is a zoonotic intracellular parasite, able to infect any warm-blooded animal via ingestion of infective stages, either contained in tissue cysts or oocysts released into the environment.
Estefania Delgado Betancourt, Benjamin Hamid, Benedikt T. Fabian, Christian Klotz, Susanne Hartmann, Frank Seeber   +5 more
doaj   +1 more source

Trying to See the Forest through the Trees: Deciphering the Nature of Memory Immunity to Mycobacterium tuberculosis

Frontiers in Immunology, 2018
The purpose of vaccination against tuberculosis and other diseases is to establish a heightened state of acquired specific resistance in which the memory immune response is capable of mediating an accelerated and magnified expression of protection to the
Ian M. Orme, Marcela I. Henao-Tamayo
doaj   +1 more source

Complexities and benefits of adopting next-generation sequencing-based tuberculosis diagnostics: a qualitative study among stakeholders in low and high-income countries

BMJ Open, 2023
Objectives To clarify perceived benefits, barriers and facilitators of Mycobacterium tuberculosis next-generation sequencing implementation in Madagascar and Canada, towards informing implementation of this diagnostic technology in public health agencies
Elysée Nouvet, Niaina Rakotosamimanana, Simon Grandjean Lapierre, Catherine-Audrey Boutin, Maxwell J Smith, Marie-Sylvianne Rabodoarivelo, Omar Mahboob   +6 more
doaj   +1 more source

Late Embryogenesis Abundant Proteins Contribute to the Resistance of Toxoplasma gondii Oocysts against Environmental Stresses

mBio, 2023
Toxoplasma gondii oocysts, which are shed in large quantities in the feces from infected felines, are very stable in the environment, resistant to most inactivation procedures, and highly infectious. The oocyst wall provides an important physical barrier
David Arranz-Solís, David Warschkau, Benedikt T. Fabian, Frank Seeber, Jeroen P. J. Saeij   +4 more
doaj   +1 more source

Longitudinal Variations of M. tuberculosis-Induced IFN-γ Responses in HIV-Negative Pregnant Women Exposed to Tuberculosis

Frontiers in Immunology, 2021
IntroductionPregnancy triggers an alteration of the immune functions and increases the risk of developing the active tuberculosis (TB) symptoms in exposed women. The effect of pregnancy on the Mycobacterium tuberculosis-specific immune responses used for
Paulo Ranaivomanana, Rila Ratovoson, Crisca Razafimahatratra, Arimanitra Razafimahefa, Jonathan Hoffmann, Perlinot Herindrainy, Julio Rakotonirina, Niaina Rakotosamimanana   +7 more
doaj   +1 more source

Sporulation in mycobacteria [PDF]

Proceedings of the National Academy of Sciences, 2009
Mycobacteria owe their success as pathogens to their ability to persist for long periods within host cells in asymptomatic, latent forms before they opportunistically switch to the virulent state. The molecular mechanisms underlying the transition into dormancy and emergence from it are not clear. Here we show that old cultures of
Bhupender Singh, Nurul M. Islam, Leif A. Kirsebom, B. M. Fredrik Pettersson, Pontus Larsson, Jaydip Ghosh, Santanu Dasgupta, Sailendra Nath Sarkar   +7 more
openaire   +3 more sources