Results 41 to 50 of about 165,721 (325)

The transcriptome of Mycobacterium tuberculosis in a lipid-rich dormancy model through RNAseq analysis [PDF]

, 2017
Tuberculosis (TB) is currently the number one killer among infectious diseases worldwide. Lipids are abundant molecules during the infectious cycle of Mycobacterium tuberculosis (Mtb) and studies better mimicking its actual metabolic state during ...
Aguilar-Ayala, Diana, Deforce, Dieter, Gonzalez-Y-Merchand, Jorge A, Martin, Anandi, Palomino, Juan Carlos, Tilleman, Laurentijn, Van Nieuwerburgh, Filip, Vandamme, Peter   +7 more
core   +2 more sources

Physiology of Mycobacteria [PDF]

, 2009
Mycobacterium tuberculosis is a prototrophic, metabolically flexible bacterium that has achieved a spread in the human population that is unmatched by any other bacterial pathogen. The success of M. tuberculosis as a pathogen can be attributed to its extraordinary stealth and capacity to adapt to environmental changes throughout the course of infection.
Cook, Gregory M., Berney, Michael, Gebhard, Susanne, Heinemann, Matthias, Cox, Robert A., Danilchanka, Olga, Niederweis, Michael   +6 more
openaire   +4 more sources

Late Embryogenesis Abundant Proteins Contribute to the Resistance of Toxoplasma gondii Oocysts against Environmental Stresses

mBio, 2023
Toxoplasma gondii oocysts, which are shed in large quantities in the feces from infected felines, are very stable in the environment, resistant to most inactivation procedures, and highly infectious. The oocyst wall provides an important physical barrier
David Arranz-Solís, David Warschkau, Benedikt T. Fabian, Frank Seeber, Jeroen P. J. Saeij   +4 more
doaj   +1 more source

Synthetic (p)ppGpp analogue is an inhibitor of stringent response in mycobacteria [PDF]

, 2017
Bacteria elicit an adaptive response against hostile conditions such as starvation and other kinds of stresses. Their ability to survive such conditions depends, in part, on stringent response pathways.
Bhardwaj, Neerupma, Chatterji, Dipankar, Flentie, Kelly, Jayaraman, Narayanaswamy, Maiti, Krishnagopal, Stallings, Christina L, Syal, Kirtimaan   +6 more
core   +2 more sources

Genomic characterization of Nontuberculous Mycobacteria

Scientific Reports, 2017
Mycobacterium tuberculosis and Mycobacterium leprae have remained, for many years, the primary species of the genus Mycobacterium of clinical and microbiological interest.
T. Fedrizzi, C. Meehan, A. Grottola, E. Giacobazzi, Giulia Fregni Serpini, S. Tagliazucchi, A. Fabio, C. Bettua, R. Bertorelli, V. De Sanctis, F. Rumpianesi, M. Pecorari, O. Jousson, E. Tortoli, N. Segata   +14 more
semanticscholar   +1 more source

Longitudinal Variations of M. tuberculosis-Induced IFN-γ Responses in HIV-Negative Pregnant Women Exposed to Tuberculosis

Frontiers in Immunology, 2021
IntroductionPregnancy triggers an alteration of the immune functions and increases the risk of developing the active tuberculosis (TB) symptoms in exposed women. The effect of pregnancy on the Mycobacterium tuberculosis-specific immune responses used for
Paulo Ranaivomanana, Rila Ratovoson, Crisca Razafimahatratra, Arimanitra Razafimahefa, Jonathan Hoffmann, Perlinot Herindrainy, Julio Rakotonirina, Niaina Rakotosamimanana   +7 more
doaj   +1 more source

Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and -9.

, 2008
The role of Toll-like receptors (TLR) and MyD88 for immune responses to Mycobacterium tuberculosis (Mtb) infection remains controversial. To address the impact of TLR-mediated pathogen recognition and MyD88-dependent signaling events on anti ...
Abel, Bafica, Blander, Branger, Brightbill, Carroll, Cooper, Drennan, Feng, Flynn, Flynn, Fremond, Fremond, Gilleron, Gutierrez, Han, Holscher, Holscher, Hsieh, Jones, Kamath, Kaufmann, Kaufmann, Kawai, Krieg, MacMicking, MacMicking, Maher, Martinon, Means, Means, Means, Medzhitov, North, Quesniaux, Rausch, Reiling, Ryffel, Scanga, Scanga, Schaible, Seki, Shi, Shi, Shim, Sugawara, Sugawara, Sun, Takeuchi, Thoma-Uszynski, Trinchieri, Underhill, van der Wel, Yates   +53 more
core   +1 more source

Evaluation of DNA primase DnaG as a potential target for antibiotics [PDF]

, 2014
Mycobacteria contain genes for several DNA-dependent RNA primases, including dnaG, which encodes an essential replication enzyme that has been proposed as a target for antituberculosis compounds.
Aidan Doherty, Aneta Kuron, Anna Brzostek, Aravind, Bartlett, Biswas, Bozena Dziadek, Brzostek, Centers for Disease Control and Prevention, Chauhan, Ciarrocchi, Collins, Corn, Della, Draper, Dwivedi, Dye, Dziadek, Frick, Gengenbacher, Griep, Iyer, Jaroslaw Dziadek, Klann, Korycka-Machala, Kuchta, Lao-Sirieix, Lao-Sirieix, Lehman, Livak, Malgorzata Korycka-Machala, Marcin Nowosielski, Modrich, Parish, Pawelczyk, Pitcher, Pitcher, Pitcher, Raviglione, Sambrook, Snapper, Srivastava, Swart, Trias, Velayati, Weller, Weller, Zhang   +47 more
core   +1 more source

Nontuberculous Mycobacteria, Zambia

Emerging Infectious Diseases, 2009
Clinical relevance of nontuberculous mycobacteria (NTM) isolated from 180 chronically ill patients and 385 healthy controls in Zambia was evaluated to examine the contribution of these isolates to tuberculosis (TB)-like disease. The proportion of NTM-positive sputum samples was significantly higher in the patient group than in controls; 11% and 6 ...
Buijtels, PCAM, van der Sande, MABrivm, CS de, Graaff, S, Parkinson, Verbrugh, HA, Petit, PLC, van Soolingen, Drivm   +6 more
openaire   +4 more sources

Nontuberculous mycobacteria isolated from specimens of pulmonary tuberculosis suspects, Northern Tunisia: 2002–2016

BMC Infectious Diseases, 2019
Background Reports on the worldwide ascending trend of pulmonary nontuberculous mycobacteria (NTM) isolation rates and their effective role in respiratory tract infections are compelling.
Reem Gharbi, Besma Mhenni, Saloua Ben Fraj, Helmi Mardassi   +3 more
doaj   +1 more source