Results 81 to 90 of about 648,089 (387)

ACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteria [PDF]

, 2009
Mycolic acids are essential for the survival, virulence and antibiotic resistance of the human pathogen Mycobacterium tuberculosis. Inhibitors of mycolic acid biosynthesis, such as isoniazid and ethionamide, have been used as efficient drugs for the ...
Bazet Lyonnet, Bernardo, de la Iglesia, Agustina Inés, Gago, Gabriela Marisa, Gramajo, Hugo Cesar, Kurth, Daniel German, Lin, Ting Wang, Morbidoni, Héctor Ricardo, Tsai, Shiou Chuan   +7 more
core   +2 more sources

Immunology of Mycobacterium tuberculosis Infections

Microbiology spectrum, 2019
Tuberculosis (TB) is a serious global public health challenge that results in significant morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium tuberculosis (M.
J. K. Sia, Jyothi Rengarajan
semanticscholar   +1 more source

Tuberculosis due to Mycobacterium bovis and Mycobacterium caprae in sheep [PDF]

The Veterinary Journal, 2012
Tuberculosis was diagnosed in three flocks of sheep in Galicia, Spain, in 2009 and 2010. Two flocks were infected with Mycobacterium bovis and one flock was infected with Mycobacterium caprae. Infection was confirmed by the comparative intradermal tuberculin test, bacteriology, molecular analysis and histopathology. Sheep have the potential to act as a
Antón Ocampo, Juan Francisco García Marín, Ana Balseiro, Jose Luis Saez, Lucas Domínguez, Christian Gortázar, Marta Muñoz Mendoza, Jorge Mourelo, S. Menéndez, Lucía de Juan   +9 more
openaire   +5 more sources

Nanocarrier‐Based Targeting of Pattern Recognition Receptors as an Innovative Strategy for Enhancing Sepsis Therapy

Advanced Healthcare Materials, EarlyView.
This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail, Vincent O. Nyandoro, Calvin A. Omolo, Thirumala Govender   +3 more
wiley   +1 more source

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

Preparation and in vivo evaluation of glyco-gold nanoparticles carrying synthetic mycobacterial hexaarabinofuranoside

Beilstein Journal of Nanotechnology, 2020
A number of bacterial glycans are specific markers for the detection and the serological identification of microorganisms and are also widely used as antigenic components of vaccines.
Gennady L. Burygin, Polina I. Abronina, Nikita M. Podvalnyy, Sergey A. Staroverov, Leonid O. Kononov, Lev A. Dykman   +5 more
doaj   +1 more source

Early Drug Development and Evaluation of Putative Antitubercular Compounds in the -Omics Era

Frontiers in Microbiology, 2021
Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis. According to the WHO, the disease is one of the top 10 causes of death of people worldwide.
Alina Minias, Lidia Żukowska, Lidia Żukowska, Ewelina Lechowicz, Ewelina Lechowicz, Filip Gąsior, Filip Gąsior, Agnieszka Knast, Agnieszka Knast, Sabina Podlewska, Sabina Podlewska, Daria Zygała, Daria Zygała, Jarosław Dziadek   +13 more
doaj   +1 more source

Mycobacterium ulcerans infection: control, diagnosis, and treatment. [PDF]

, 2006
The skin disease Buruli ulcer, caused by Mycobacterium ulcerans, is the third most common mycobacterial disease after tuberculosis and leprosy and mainly affects remote rural African communities. Although the disease is known to be linked to contaminated
Adjei, Amofah, Amofah, Andries, Aujoulat, Bentoucha, Darie, Debacker, Debacker, Debacker, Dega, Dega, Dhople, Dhople, Dhople, Drummond, Eddyani, Eric Comte, Espey, Etuaful, Evans, Evans, Fabienne Nackers, Fehr, Françoise Portaels, Guédénon, Hospers, Huygen, Johnson, Johnson, Johnson, Kanga, Kanga, Kanga, Klutse, Marsollier, Marsollier, Marsollier, Marsollier, Marsollier, Marston, Meyers, Mve-Obiang, Nakanaga, Noeske, Okenu, Phillips, Phillips, Portaels, Pszolla, Raghunathan, Revill, Rhodes, Scott, Siegmund, Smith, Stienstra, Stienstra, Stragier, Tanghe, Thangaraj, van der Werf, van der Werf, Veitch, Vinciane Sizaire   +64 more
core   +2 more sources

A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation

Hepatology, EarlyView., 2022
In this study of the gut mucosal microbiota in primary sclerosing cholangitis (PSC), we found consistent microbiota features associated with PSC and recurrent PSC, PSC with inflammatory bowel disease and a persistent gut dysbiosis after liver transplantation Abstract Background and Aims Several characteristic features of the fecal microbiota have been ...
Mikal Jacob Hole, Kristin Kaasen Jørgensen, Kristian Holm, Peder R. Braadland, Malin Holm Meyer‐Myklestad, Asle Wilhelm Medhus, Dag Henrik Reikvam, Alexandra Götz, Krzysztof Grzyb, Kirsten Muri Boberg, Tom Hemming Karlsen, Martin Kummen, Johannes R. Hov   +12 more
wiley   +1 more source

Mycobacterium tuberculosis is less likely to acquire pathogenic mutations during latent infection than during active disease

Microbiology Spectrum
Most people infected with Mycobacterium tuberculosis (Mtb) are believed to be in a state of latent tuberculosis (TB) infection (LTBI). Although LTBI is asymptomatic and not infectious, there is a risk of developing active disease even decades after ...
Asami Osugi, Aki Tamaru, Takashi Yoshiyama, Tomotada Iwamoto, Satoshi Mitarai, Yoshiro Murase   +5 more
doaj   +1 more source