Results 1 to 10 of about 105,796 (273)
Cbl promotes MyD88 ubiquitin-mediated degradation in macrophages via phosphorylation and calcium mobilization [PDF]
Frontiers in ImmunologyBackgroundPrecise regulation of Toll-like receptor (TLR) signaling via myeloid differentiation factor 88 (MyD88) is critical for balancing immune defense and inflammation.
Yan Zhang +7 more
doaj +2 more sources
The MyD88+ phenotype is an adverse prognostic factor in epithelial ovarian cancer. [PDF]
PLoS ONE, 2014 The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresistance. Recent evidence points to the Toll-like receptor-4 (TLR4), and particularly its adaptor protein MyD88, as one potential mediator of this resistance ...
Charles J d'Adhemar +26 more
doaj +6 more sources
TLR4‐IN‐C34 protects against acute kidney injury via modulating TLR4/MyD88/NF-κb axis, MAPK, and apoptosis [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Acute kidney injury (AKI) is a major component of isoproterenol (ISO) induced cardiorenal syndrome. In this study, we investigated the effect of TLR4‐IN‐C34 as a toll-like receptor (TLR)-4 inhibitor on ameliorating ISO-induced AKI and the ...
Hadeer Abdelsalam +2 more
doaj +1 more source
Toll-like receptor signaling in vertebrates: Testing the integration of protein, complex, and pathway data in the Protein Ontology framework [PDF]
, 2015 The Protein Ontology (PRO) provides terms for and supports annotation of species-specific protein complexes in an ontology framework that relates them both to their components and to species-independent families of complexes.
Arighi, Cecilia +7 more
core +17 more sources
OncoImmunology, 2021 Although pharmacological stimulation of TLRs has anti-tumor effects, it has not been determined whether endogenous stimulation of TLRs can lead to tumor rejection.
Diana Shah +10 more
doaj +1 more source
Gut Microbes, 2022 In healthy hosts the gut microbiota is restricted to gut tissues by several barriers some of which require MyD88-dependent innate immune sensor pathways. Nevertheless, some gut taxa have been reported to disseminate to systemic tissues.
Sreeram Udayan +12 more
doaj +1 more source
Filtered Kombucha Tea Rings the Bell for TLR2, TLR4, MYD88, and Dectin-1 in Mice Model of Colitis [PDF]
Research Journal of Pharmacognosy, 2020 Background and objectives: TLR2, TLR4, and Dectin-1 (Clec7) are pattern recognition receptors (PRRs) expressed by intestinal epithelia cells and MYD88 is a signaling molecule of TLR2 and TLR4.
Elaheh Mahmoudi* +2 more
doaj +1 more source
Virulence, 2021 Toll-like receptors (TLRs) are essential for the protection of the host from pathogen infections by initiating the integration of contextual cues to regulate inflammation and immunity.
Jian Shang +10 more
doaj +1 more source
LncRNA NEAT1 activates MyD88/NF-κB pathway in bronchopneumonia through targeting miR-155-5p
Autoimmunity, 2021 Background Bronchopneumonia is a disease of the respiratory tract. It leads to other complications and endangers life and health. Long non-coding RNA (lncRNA) participates in the occurrence and development of bronchopneumonia.
Ling-jia Chen +9 more
doaj +1 more source
Redox Report, 2021 Objectives The study explores the protective role of the peripheral serum of limb remote ischemic postconditioning (LRIP) in reducing the reactive oxygen species (ROS) levels and neutrophil activation, which are responsible for the deleterious ...
Gangling Chen +7 more
doaj +1 more source