Results 1 to 10 of about 123,738 (330)
Cbl promotes MyD88 ubiquitin-mediated degradation in macrophages via phosphorylation and calcium mobilization. [PDF]
Front ImmunolBackgroundPrecise regulation of Toll-like receptor (TLR) signaling via myeloid differentiation factor 88 (MyD88) is critical for balancing immune defense and inflammation.
Zhang Y +6 more
europepmc +2 more sources
The MyD88+ phenotype is an adverse prognostic factor in epithelial ovarian cancer. [PDF]
PLoS ONE, 2014 The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresistance. Recent evidence points to the Toll-like receptor-4 (TLR4), and particularly its adaptor protein MyD88, as one potential mediator of this resistance ...
Charles J d'Adhemar +26 more
doaj +6 more sources
IRF3 and IRF8 Regulate NF-κB Signaling by Targeting MyD88 in Teleost Fish
Frontiers in Immunology, 2020 MyD88 is a conserved intracellular adaptor, which plays an important role in the innate immune system. MyD88 transmits signals for downstream of toll-like and IL-1 receptors to activate NF-κB signaling pathway, which is tightly controlled in the immune ...
Xiaolong Yan +8 more
doaj +2 more sources
TLR4‐IN‐C34 protects against acute kidney injury via modulating TLR4/MyD88/NF-κb axis, MAPK, and apoptosis [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Acute kidney injury (AKI) is a major component of isoproterenol (ISO) induced cardiorenal syndrome. In this study, we investigated the effect of TLR4‐IN‐C34 as a toll-like receptor (TLR)-4 inhibitor on ameliorating ISO-induced AKI and the ...
Hadeer Abdelsalam +2 more
doaj +1 more source
The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways
Cell Reports, 2022 SUMMARY Interleukin-1 receptor-associated kinases (IRAKs) −4, −2, and −1 are involved in transducing signals from Toll-like receptors (TLRs) via the adaptor myeloid differentiation primary-response protein 88 (MYD88).
Milton C. A. Pereira +6 more
semanticscholar +1 more source
OncoImmunology, 2021 Although pharmacological stimulation of TLRs has anti-tumor effects, it has not been determined whether endogenous stimulation of TLRs can lead to tumor rejection.
Diana Shah +10 more
doaj +1 more source
Nature Communications, 2021 Pathways to control the spreading of α-synuclein (α-syn) and associated neuropathology in Parkinson’s disease (PD), multiple system atrophy (MSA) and dementia with Lewy bodies (DLB) are unclear.
Debashis Dutta +5 more
semanticscholar +1 more source
Toll-like receptor signaling in vertebrates: Testing the integration of protein, complex, and pathway data in the Protein Ontology framework [PDF]
, 2015 The Protein Ontology (PRO) provides terms for and supports annotation of species-specific protein complexes in an ontology framework that relates them both to their components and to species-independent families of complexes.
Arighi, Cecilia +7 more
core +12 more sources
Gut Microbes, 2022 In healthy hosts the gut microbiota is restricted to gut tissues by several barriers some of which require MyD88-dependent innate immune sensor pathways. Nevertheless, some gut taxa have been reported to disseminate to systemic tissues.
Sreeram Udayan +12 more
doaj +1 more source
MyD88-dependent signaling drives toll-like receptor-induced trained immunity in macrophages
bioRxiv, 2022 Immunocompromised populations are highly vulnerable to developing life-threatening infections. Strategies to protect patients with weak immune responses are urgently needed. Employing trained immunity, whereby innate leukocytes undergo reprogramming upon
Allison M. Owen +13 more
semanticscholar +1 more source