Results 11 to 20 of about 123,738 (330)
Advanced Science, 2022 Diabetes manifests as chronic inflammation and leads to the development diabetic cardiomyopathy (DCM). Targeting key proteins in inflammatory signaling may provide new therapy for DCM.
Wu Luo +9 more
semanticscholar +4 more sources
MyD88 in hepatic stellate cells enhances liver fibrosis via promoting macrophage M1 polarization
Cell Death and Disease, 2022 During liver fibrosis, quiescent HSCs (qHSCs) are activated to become activated HSCs (aHSCs)/myofibroblasts. The signal adapter MyD88, an essential component of TLR signaling, plays an important role in liver fibrosis.
J Zhang +8 more
semanticscholar +1 more source
Virulence, 2021 Toll-like receptors (TLRs) are essential for the protection of the host from pathogen infections by initiating the integration of contextual cues to regulate inflammation and immunity.
Jian Shang +10 more
doaj +1 more source
Osteocytes directly regulate osteolysis via MYD88 signaling in bacterial bone infection
Nature Communications, 2022 The impact of bone cell activation on bacterially-induced osteolysis remains elusive. Here, we show that matrix-embedded osteocytes stimulated with bacterial pathogen-associated molecular patterns (PAMPs) directly drive bone resorption through an MYD88 ...
T. Yoshimoto +10 more
semanticscholar +1 more source
Immunologic research, 2021 The continuous emergence of infectious pathogens along with antimicrobial resistance creates a need for an alternative approach to treat infectious diseases.
K. Saikh
semanticscholar +1 more source
LncRNA NEAT1 activates MyD88/NF-κB pathway in bronchopneumonia through targeting miR-155-5p
Autoimmunity, 2021 Background Bronchopneumonia is a disease of the respiratory tract. It leads to other complications and endangers life and health. Long non-coding RNA (lncRNA) participates in the occurrence and development of bronchopneumonia.
Ling-jia Chen +9 more
doaj +1 more source
Insights on the role of TLR-4 in neuroinflammation: a hint on COVID-19 relationship
Archives of Pharmaceutical Sciences Ain Shams University, 2023 Neuroinflammation plays a crucial role in cognitive decline and neurodegenerative diseases, such as Alzheimer's. Within the central nervous system, microglia express Toll-like receptor 4 (TLR-4) abundantly, which prompts the secretion of proinflammatory ...
Salma A. Elshafey +3 more
doaj +1 more source
Journal of food biochemistry, 2021 Although astragaloside IV protects from acute myocardial infarction (AMI)-induced chronic heart failure (CHF), the underlying mechanism of action is unclear.
Hui Shi +8 more
semanticscholar +1 more source
Filtered Kombucha Tea Rings the Bell for TLR2, TLR4, MYD88, and Dectin-1 in Mice Model of Colitis [PDF]
Research Journal of Pharmacognosy, 2020 Background and objectives: TLR2, TLR4, and Dectin-1 (Clec7) are pattern recognition receptors (PRRs) expressed by intestinal epithelia cells and MYD88 is a signaling molecule of TLR2 and TLR4.
Elaheh Mahmoudi* +2 more
doaj +1 more source
The Bug in MyD88 Dependency [PDF]
Immunity, 2006 The contribution of MyD88 adaptor-mediated signaling in immune responses to fungi is largely unexplored. In this issue of Immunity, show that MyD88 is dispensable in several aspects of dendritic-cell trafficking and T cell differentiation in response to a respiratory fungus.
van Lier, René A. W., Lutter, René
openaire +3 more sources