Results 21 to 30 of about 123,738 (330)

Circ-UQCRC2 aggravates lipopolysaccharide-induced injury in human bronchial epithelioid cells via targeting miR-495-3p/MYD88-mediated inflammatory response and oxidative stress

Autoimmunity, 2021
Infantile pneumonia is a common inflammatory disease with the infections of various pathogens in lower respiratory tracts. Here, the role and working mechanism of circular RNA (circRNA) ubiquinol-cytochrome c reductase core protein 2 (circ-UQCRC2 ...
Xuan Zhang, Chunbao Chen, Bei Li, Wei Lu
doaj   +1 more source

MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography

Nature Communications, 2021
MyD88 and MAL are Toll-like receptor (TLR) adaptors that signal to induce pro-inflammatory cytokine production. We previously observed that the TIR domain of MAL (MALTIR) forms filaments in vitro and induces formation of crystalline higher-order ...
Max T. B. Clabbers, S. Holmes, T. Muusse, P. Vajjhala, S. Thygesen, A. Malde, Dominic J. B. Hunter, T. Croll, L. Flueckiger, J. Nanson, Md. Habibur Rahaman, A. Aquila, M. Hunter, M. Liang, C. Yoon, Jingjing Zhao, N. Zatsepin, B. Abbey, E. Sierecki, Y. Gambin, K. Stacey, C. Darmanin, B. Kobe, Hongyi Xu, T. Ve   +24 more
semanticscholar   +1 more source

MYD88 L265P mutation and interleukin‐10 detection in cerebrospinal fluid are highly specific discriminating markers in patients with primary central nervous system lymphoma: results from a prospective study

British Journal of Haematology, 2021
Reliable biomarkers are needed to avoid diagnostic delay and its devastating effects in patients with primary central nervous system (CNS) lymphoma (PCNSL).
A. Ferreri, T. Calimeri, P. Lopedote, Ilaria Francaviglia, R. Daverio, C. Iacona, C. Belloni, S. Steffanoni, A. Gulino, E. Anghileri, Angelo Diffidenti, A. Finardi, F. Gagliardi, N. Anzalone, A. Nonis, R. Furlan, D. De Lorenzo, M. Terreni, V. Martinelli, M. Sassone, M. Foppoli, P. Angelillo, E. Guggiari, A. Falini, P. Mortini, M. Filippi, V. Tarantino, M. Eoli, F. Ciceri, C. Doglioni, C. Tripodo, M. Locatelli, M. Cangi, M. Ponzoni   +33 more
semanticscholar   +1 more source

TLR4 knockdown by miRNA-140-5p improves tendinopathy: an in vitr o study

Archives of Medical Science, 2020
Introduction The purpose of this study was to determine whether TLR4 knockdown induced by miRNA-140-5p improves tendinopathy in an in vitro experiment. Material and methods Extraction of tendon-derived stem cells (TDSCs) from SD rats was performed using
Tu Jun, Guo Ruipeng, Xu Bin
doaj   +1 more source

Serum of limb remote ischemic postconditioning inhibits fMLP-triggered activation and reactive oxygen species releasing of rat neutrophils

Redox Report, 2021
Objectives The study explores the protective role of the peripheral serum of limb remote ischemic postconditioning (LRIP) in reducing the reactive oxygen species (ROS) levels and neutrophil activation, which are responsible for the deleterious ...
Gangling Chen, Jiangwei Zhang, Mingyue Sheng, Sanli Zhang, Qi Wu, Lei Liu, Boyang Yu, Junping Kou   +7 more
doaj   +1 more source

The cationic liposome CCS/C adjuvant induces immunity to influenza independently of the adaptor protein MyD88

Human Vaccines & Immunotherapeutics, 2020
Traditional non-living vaccines are often least effective in the populations that need them most, such as neonates and elderly adults. Vaccine adjuvants are one approach to boost the immunogenicity of antigens in populations with reduced immunity ...
Orli Even-Or, Shani Avniel-Polak, Yechezkel Barenholz, Gabriel Nussbaum   +3 more
doaj   +1 more source

MyD88 in myofibroblasts enhances colitis-associated tumorigenesis via promoting macrophage M2 polarization.

Cell Reports, 2021
The signal adaptor MyD88, an essential component of TLR signaling, plays an important role in gut-microbiome interactions. However, its contribution to colitis-associated cancer (CAC) is still controversial.
Qi Yuan, Jianchun Gu, J Zhang, Shi Liu, Qinchuan Wang, Tian Tian, Zhinan Chen, Jinhua Zhang   +7 more
semanticscholar   +1 more source

Reconstructing the TIR side of the Myddosome: a paradigm for TIR-TIR interactions? [PDF]

, 2015
Members of the Toll-like receptor and interleukin-1 (IL-1) receptor families all signal via Toll/IL-1R (TIR) domain-driven assemblies with adaptors such as MyD88.
Bovijn, Celia, Burg, Elianne, Pauwels, Ewald, Peelman, Frank, Ruyssinck, Elien, Tavernier, Jan, Van Acker, Tim, Vyncke, Laurens   +7 more
core   +2 more sources

Unresponsiveness of MyD88-deficient mice to endotoxin.

Immunity, 1999
MyD88 is a general adaptor protein that plays an important role in the Toll/IL-1 receptor family signalings. Recently, Toll-like receptors 2 and 4 (TLR2 and TLR4) have been suggested to be the signaling receptors for lipopolysaccharide (LPS).
T. Kawai, O. Adachi, T. Ogawa, K. Takeda, S. Akira   +4 more
semanticscholar   +1 more source

Emerging targets in human lymphoma: targeting the MYD88 mutation [PDF]

, 2016
B cell neoplasms co-opt the molecular machinery of normal B cells for their survival. Technological advances in cancer genomics has significantly contributed to uncovering the root cause of aggressive lymphomas, revealing a previously unknown link ...
Horikawa, Keisuke, Jeelall, Yogesh S., Wang, James Q.   +2 more
core   +1 more source