Results 21 to 30 of about 105,796 (273)

Overexpression of the toll-like receptor (TLR) signaling adaptor MYD88, but lack of genetic mutation, in myelodysplastic syndromes. [PDF]

PLoS ONE, 2013
MYD88 is a key mediator of Toll-like receptor innate immunity signaling. Oncogenically active MYD88 mutations have recently been reported in lymphoid malignancies, but has not been described in MDS.
Sophie Dimicoli, Yue Wei, Carlos Bueso-Ramos, Hui Yang, Courtney Dinardo, Yu Jia, Hong Zheng, Zhihong Fang, Martin Nguyen, Sherry Pierce, Rui Chen, Hui Wang, Chenghua Wu, Guillermo Garcia-Manero   +13 more
doaj   +1 more source

Drug-like analogues of the parasitic worm-derived immunomodulator ES-62 are therapeutic in the MRL/Lpr model of systemic lupus erythematosus [PDF]

, 2015
Introduction ES-62, a phosphorylcholine (PC)-containing immunomodulator secreted by the parasitic worm Acanthocheilonema viteae, protects against nephritis in the MRL/Lpr mouse model of systemic lupus erythematosus (SLE).
Harnett, M. M., Harnett, W., Pineda, M. A., Rodgers, D. T., Suckling, C. J.   +4 more
core   +1 more source

Mapping the human T cell repertoire to recurrent driver mutations in MYD88 and EZH2 in lymphoma

OncoImmunology, 2017
Oncogenic “driver” mutations are theoretically attractive targets for the immunotherapy of lymphoid cancers, yet the proportion that can be recognized by T cells remains poorly defined. To address this issue without any confounding effects of the patient'
Julie S. Nielsen, Andrew R. Chang, Darin A. Wick, Colin G. Sedgwick, Zusheng Zong, Andrew J. Mungall, Spencer D. Martin, Natalie N. Kinloch, Susann Ott-Langer, Zabrina L. Brumme, Steven P. Treon, Joseph M. Connors, Randy D. Gascoyne, John R. Webb, Brian R. Berry, Ryan D. Morin, Nicol Macpherson, Brad H. Nelson   +17 more
doaj   +1 more source

TLR4 knockdown by miRNA-140-5p improves tendinopathy: an in vitr o study

Archives of Medical Science, 2020
Introduction The purpose of this study was to determine whether TLR4 knockdown induced by miRNA-140-5p improves tendinopathy in an in vitro experiment. Material and methods Extraction of tendon-derived stem cells (TDSCs) from SD rats was performed using
Tu Jun, Guo Ruipeng, Xu Bin
doaj   +1 more source

Hematopoietic but not endothelial cell MyD88 contributes to host defense during gram-negative pneumonia derived sepsis. [PDF]

PLoS Pathogens, 2014
Klebsiella pneumoniae is an important cause of sepsis. The common Toll-like receptor adapter myeloid differentiation primary response gene (MyD)88 is crucial for host defense against Klebsiella.
Miriam H P van Lieshout, Adam A Anas, Sandrine Florquin, Baidong Hou, Cornelis van't Veer, Alex F de Vos, Tom van der Poll   +6 more
doaj   +1 more source

Schisandrin B Attenuates Diabetic Cardiomyopathy by Targeting MyD88 and Inhibiting MyD88‐Dependent Inflammation

Advanced Science, 2022
AbstractDiabetes manifests as chronic inflammation and leads to the development diabetic cardiomyopathy (DCM). Targeting key proteins in inflammatory signaling may provide new therapy for DCM. In this study, the authors explore the pharmacological effects and mechanisms of Schisandrin B (Sch B), a natural compound with anti‐inflammatory activity ...
Wu Luo, Ke Lin, Junyi Hua, Jibo Han, Qiuyan Zhang, Lingfeng Chen, Zia A. Khan, Gaojun Wu, Yi Wang, Guang Liang   +9 more
openaire   +3 more sources

The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma [PDF]

, 2016
Chronic asthma is associated with persistent lung inflammation and long-term remodelling of the airways that have proved refractory to conventional treatments such as steroids, despite their efficacy in controlling acute airway contraction and bronchial ...
Al-Riyami, L., Coltherd, J. C., Harnett, M. M., Harnett, W., Lawrie, R. E., Rodgers, D. T., Suckling, C. J.   +6 more
core   +1 more source

Macrophage mediated recognition and clearance of Borrelia burgdorferi elicits MyD88-dependent and -independent phagosomal signals that contribute to phagocytosis and inflammation

BMC Immunology, 2021
Background Macrophages play prominent roles in bacteria recognition and clearance, including Borrelia burgdorferi (Bb), the Lyme disease spirochete. To elucidate mechanisms by which MyD88/TLR signaling enhances clearance of Bb by macrophages, we studied ...
Sarah J. Benjamin, Kelly L. Hawley, Paola Vera-Licona, Carson J. La Vake, Jorge L. Cervantes, Yijun Ruan, Justin D. Radolf, Juan C. Salazar   +7 more
doaj   +1 more source

Long noncoding RNA MyD88 functions as a promising diagnostic biomarker in hepatocellular carcinoma

Frontiers in Endocrinology, 2023
BackgroundHepatocellular carcinoma (HCC) is one of the most frequent malignancies. Alpha-fetoprotein (AFP) has some limitations in diagnosing early HCC.
Zhihuai Wang, Zhihuai Wang, Peng Gao, Weijun Sun, Adeel ur Rehman, Jiakai Jiang, Suobao Xu, Cailin Xue, Chunfu Zhu, Chunfu Zhu, Xihu Qin, Xihu Qin   +11 more
doaj   +1 more source

Mast cell subsets and their functional modulation by the Acanthocheilonema viteae product ES-62 [PDF]

, 2013
ES-62, an immunomodulator secreted by filarial nematodes, exhibits therapeutic potential in mouse models of allergic inflammation, at least in part by inducing the desensitisation of Fc휀RI-mediated mast cell responses.
Al-Riyami, Lamyaa, Ball, Dimity, Bell, Kara, Coates, Michelle, Harnett, Margaret, Harnett, William, Rzepecka, Justyna, Tay, Hwee Kee   +7 more
core   +2 more sources