Results 31 to 40 of about 105,796 (273)

Role of MyD88 in adenovirus keratitis [PDF]

Immunology & Cell Biology, 2016
Pattern recognition receptors (PRRs) are critical to the early detection and innate immune responses to pathogens. In particular, the toll‐like receptor (TLR) system and its associated adaptor proteins have essential roles in early host responses to infection.
Zhou, Xiaohong, Rajaiya, Jaya, Chodosh, James, Ramke, Mirja, Chintakuntlawar, Ashish V., Lee, Jeong Yoon   +5 more
openaire   +3 more sources

Single Cell Analysis of MYD88 L265P and MYD88 WT Waldenström Macroglobulinemia Patients

Blood, 2021
Abstract Waldenström macroglobulinemia (WM) is a low-grade B- cell lymphoproliferative disorder characterized by bone marrow (BM) infiltration by small lymphoplasmacytic lymphoma (LPL) cells that secrete monoclonal IgM immunoglobulin. Our understanding of the pathogenesis of WM has improved significantly by the discovery that the vast ...
Tina Bagratuni, Foteini Aktypi, Maria Sakkou, Kleio Maria Verrou, Nefeli Mavrianou-Koutsoukou, Dimitrios Patseas, Christine Ivy Liacos, Stamatia Skourti, Alexandra Papadimou, Foteini Theodorakakou, George Kollias, Petros Sfikakis, Maria Gavriatopoulou, Evangelos Terpos, Meletios A. Dimopoulos, Efstathios Kastritis   +15 more
openaire   +1 more source

TLR2, TLR4 and the MyD88 signaling are crucial for the in vivo generation and the longevity of long-lived antibody-secreting cells. [PDF]

PLoS ONE, 2013
This study was undertaken to gain better insights into the role of TLRs and MyD88 in the development and differentiation of memory B cells, especially of ASC, during the Th2 polarized memory response induced by Natterins.
Evilin Naname Komegae, Lidiane Zito Grund, Monica Lopes-Ferreira, Carla Lima   +3 more
doaj   +1 more source

A Salmonella virulence factor activates the NOD1/NOD2 signaling pathway. [PDF]

, 2011
The invasion-associated type III secretion system (T3SS-1) of Salmonella enterica serotype Typhimurium (S. Typhimurium) activates the transcription factor NF-κB in tissue culture cells and induces inflammatory responses in animal models through unknown ...
Bäumler, Andreas J, Keestra, A Marijke, Kim, Anita, Klein-Douwel, Daisy, Tsolis, Renée M, Winter, Maria G, Winter, Sebastian E, Xavier, Mariana N   +7 more
core   +2 more sources

PYK2 interacts with MyD88 and regulates MyD88-mediated NF-κB activation in macrophages [PDF]

Journal of Leukocyte Biology, 2009
Abstract PYK2 regulates inflammation by modulating MyD88 signaling. PYK2, a major cell adhesion-activated tyrosine kinase, is highly expressed in macrophages and implicated in macrophage activation and inflammatory response.
Cai-Xia, Xi, Fei, Xiong, Zheng, Zhou, Lin, Mei, Wen-Cheng, Xiong   +4 more
openaire   +2 more sources

A Novel Kindred with MyD88 Deficiency

Journal of Clinical Immunology, 2022
sponsorship: IM is a senior clinical investigator at the Research Foundation - Flanders (FWO) and is supported by the CSL Behring Chair of Primary Immunodeficiencies; by a KU Leuven C1 Grant [grant number C16/18/007]; by a VIB GC PID Grant; by the Research Foundation -Flanders (FWO) [grant numbers G0C8517N, G0B5120N, and G0E8420N]; and by the Jeffrey ...
Bucciol, Giorgia, Moens, Leen, Corveleyn, Anniek, Dreesman, Alexandra, Meyts, Isabelle   +4 more
openaire   +3 more sources

In vitro study of momordin Ic in improving atopic dermatitis by regulating claudin-1/MyD88 and targeting NLRP3 [PDF]

Acta Poloniae Pharmaceutica
Atopic dermatitis (AD) is a non-infectious inflammatory skin disease characterized by persistent itching of the skin, and it has become a global health problem with increasing incidence and complex pathogenesis.
Ying Guo, Litao Wang, Jing Zhang, Tingting Jing, Lefan Fu, Guoying Miao   +5 more
doaj   +1 more source

Activation of MyD88 signaling upon staphylococcal enterotoxin binding to MHC class II molecules. [PDF]

PLoS ONE, 2011
Ligands binding to Toll-like receptor (TLR), interleukin 1 receptor (IL-1R), or IFN-γR1 are known to trigger MyD88-mediated signaling, which activates pro-inflammatory cytokine responses. Recently we reported that staphylococcal enterotoxins (SEA or SEB),
Teri L Kissner, Gordon Ruthel, Shahabuddin Alam, Robert G Ulrich, Stefan Fernandez, Kamal U Saikh   +5 more
doaj   +1 more source

Metagenomic deep sequencing of aqueous fluid detects intraocular lymphomas. [PDF]

, 2017
IntroductionCurrently, the detection of pathogens or mutations associated with intraocular lymphomas heavily relies on prespecified, directed PCRs. With metagenomic deep sequencing (MDS), an unbiased high-throughput sequencing approach, all pathogens as ...
Acharya, Nisha, Bloomer, Michele, DeRisi, Joseph L, Doan, Thuy, Gonzales, John, Shantha, Jessica G, Wilson, Michael R   +6 more
core   +1 more source

Leukotriene B4-receptor-1 mediated host response shapes gut microbiota and controls colon tumor progression

OncoImmunology, 2017
Inflammation and infection are key promoters of colon cancer but the molecular interplay between these events is largely unknown. Mice deficient in leukotriene B4 receptor1 (BLT1) are protected in inflammatory disease models of arthritis, asthma and ...
Venkatakrishna R. Jala, Paramahamsa Maturu, Sobha R. Bodduluri, Elangovan Krishnan, Steven Mathis, Krishnaprasad Subbarao, Min Wang, Alfred B. Jenson, Mary L. Proctor, Eric C. Rouchka, Rob Knight, Bodduluri Haribabu   +11 more
doaj   +1 more source