Results 41 to 50 of about 123,738 (330)
Oxidative Medicine and Cellular Longevity, 2020 Background It is widely accepted that inflammation may contribute to cognitive impairment in patients with vascular dementia (VD). Our prior clinical researches have reported that acupuncture can alleviate cognitive function in VD, but the underlying ...
Lu Wang +8 more
semanticscholar +1 more source
BMC Immunology, 2021 Background Macrophages play prominent roles in bacteria recognition and clearance, including Borrelia burgdorferi (Bb), the Lyme disease spirochete. To elucidate mechanisms by which MyD88/TLR signaling enhances clearance of Bb by macrophages, we studied ...
Sarah J. Benjamin +7 more
doaj +1 more source
Role of MyD88 in adenovirus keratitis [PDF]
Immunology & Cell Biology, 2016 Pattern recognition receptors (PRRs) are critical to the early detection and innate immune responses to pathogens. In particular, the toll‐like receptor (TLR) system and its associated adaptor proteins have essential roles in early host responses to infection.
Zhou, Xiaohong +5 more
openaire +3 more sources
Single Cell Analysis of MYD88 L265P and MYD88 WT Waldenström Macroglobulinemia Patients
Blood, 2021 Abstract Waldenström macroglobulinemia (WM) is a low-grade B- cell lymphoproliferative disorder characterized by bone marrow (BM) infiltration by small lymphoplasmacytic lymphoma (LPL) cells that secrete monoclonal IgM immunoglobulin. Our understanding of the pathogenesis of WM has improved significantly by the discovery that the vast ...
Tina Bagratuni +15 more
openaire +1 more source
Long noncoding RNA MyD88 functions as a promising diagnostic biomarker in hepatocellular carcinoma
Frontiers in Endocrinology, 2023 BackgroundHepatocellular carcinoma (HCC) is one of the most frequent malignancies. Alpha-fetoprotein (AFP) has some limitations in diagnosing early HCC.
Zhihuai Wang +11 more
doaj +1 more source
Inflammatory Role of TLR-MyD88 Signaling in Multiple Sclerosis
Frontiers in Molecular Neuroscience, 2020 Multiple sclerosis (MS) is a neuro-autoimmune and neurodegenerative disorder leading to chronic inflammation, demyelination, axonal, and neuronal loss in the central nervous system (CNS).
Chao Zheng +4 more
semanticscholar +1 more source
Metagenomic deep sequencing of aqueous fluid detects intraocular lymphomas. [PDF]
, 2017 IntroductionCurrently, the detection of pathogens or mutations associated with intraocular lymphomas heavily relies on prespecified, directed PCRs. With metagenomic deep sequencing (MDS), an unbiased high-throughput sequencing approach, all pathogens as ...
Acharya, Nisha +6 more
core +1 more source
TLR2, TLR4 and the MyD88 signaling are crucial for the in vivo generation and the longevity of long-lived antibody-secreting cells. [PDF]
PLoS ONE, 2013 This study was undertaken to gain better insights into the role of TLRs and MyD88 in the development and differentiation of memory B cells, especially of ASC, during the Th2 polarized memory response induced by Natterins.
Evilin Naname Komegae +3 more
doaj +1 more source
PYK2 interacts with MyD88 and regulates MyD88-mediated NF-κB activation in macrophages [PDF]
Journal of Leukocyte Biology, 2009 Abstract PYK2 regulates inflammation by modulating MyD88 signaling. PYK2, a major cell adhesion-activated tyrosine kinase, is highly expressed in macrophages and implicated in macrophage activation and inflammatory response.
Cai-Xia, Xi +4 more
openaire +2 more sources
A Novel Kindred with MyD88 Deficiency
Journal of Clinical Immunology, 2022 sponsorship: IM is a senior clinical investigator at the Research Foundation - Flanders (FWO) and is supported by the CSL Behring Chair of Primary Immunodeficiencies; by a KU Leuven C1 Grant [grant number C16/18/007]; by a VIB GC PID Grant; by the Research Foundation -Flanders (FWO) [grant numbers G0C8517N, G0B5120N, and G0E8420N]; and by the Jeffrey ...
Bucciol, Giorgia +4 more
openaire +3 more sources