Results 51 to 60 of about 105,796 (273)

Possible Involvement of MyD88 in Regulating Stress Response in Mice

Frontiers in Neuroscience, 2021
Myeloid differentiation primary response 88 (MyD88) is an adapter protein of the toll-like receptor (TLR) family that regulates innate immune function. Here, we identified a novel role of MyD88 in regulating stress response.
Toru Hosoi, Yosuke Yamawaki, Yosuke Yamawaki, Hitomi Kimura, Shoko Honda, Koichiro Ozawa   +5 more
doaj   +1 more source

MicroRNA-155 is induced during the macrophage inflammatory response [PDF]

, 2007
The mammalian inflammatory response to infection involves the induction of several hundred genes, a process that must be carefully regulated to achieve pathogen clearance and prevent the consequences of unregulated expression, such as cancer.
Akira, Alexopoulou, Ambros, Balkwill, Brightbill, Calder, Calin, Chendrimada, Clurman, Covert, D. Baltimore, Doyle, Dunne, G. Cheng, Haasch, Han, Hemmi, Hertzog, Jiang, K. D. Taganov, Karin, Karin, Kracht, Lam, Lecellier, Lehman, M. P. Boldin, Medzhitov, Modlin, Poltorak, R. M. O'Connell, Schroder, Shaulian, Tam, Tam, Tam, Valencia-Sanchez, van Boxel-Dezaire, van den Berg   +38 more
core   +3 more sources

The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17–producing cellular network at multiple sites [PDF]

, 2012
Among many survival strategies, parasitic worms secrete molecules to modulate host immune responses. One such product, ES-62, is protective in the collagen-induced arthritis (CIA) model of rheumatoid arthritis.
Al-Riyami, Benderdour, Chu, Collins, Conti, Cooke, Fang, Feng, Goodridge, Goodridge, Goodridge, Gulen, Harnett, Harrington, Ito, Ivanov, Kelchtermans, Kenny, Koenders, Koshy, Kulkarni, Langrish, Lubberts, Marshall, Martin, McInnes, Murugaiyan, Nakae, Naor, Niedbala, Petermann, Pickens, Price, Reynolds, Roark, Sato, Shahrara, Shibata, Staschke, Sutton, Szanto, Takayanagi, Tanaka, Vermeire, Whelan, Xu, Xu, Yago   +47 more
core   +1 more source

MyD88-Dependent and MyD88-Independent Pathways in Synergy, Priming, and Tolerance between TLR Agonists [PDF]

The Journal of Immunology, 2007
Abstract TLRs sense components of microorganisms and are critical host mediators of inflammation during infection. Different TLR agonists can profoundly alter inflammatory effects of one another, and studies suggest that the sequence of exposure to TLR agonists may importantly impact on responses during infection.
Aranya, Bagchi, Elizabeth A, Herrup, H Shaw, Warren, James, Trigilio, Hae-Sook, Shin, Catherine, Valentine, Judith, Hellman   +6 more
openaire   +2 more sources

The oncogenic human B-cell lymphoma MYD88 L265P mutation genocopies activation by phosphorylation at the Toll/interleukin-1 receptor (TIR) domain

Blood Cancer Journal, 2023
MYD88 is the key signaling adaptor-protein for Toll-like and interleukin-1 receptors. A somatic L265P mutation within the Toll/interleukin-1 receptor (TIR) domain of MYD88 is found in 90% of Waldenström macroglobulinemia cases and in a significant subset
Marthe Minderman, Hildo Lantermans, Carmen van der Zwaan, Arie J. Hoogendijk, Maartje van den Biggelaar, Marie José Kersten, Marcel Spaargaren, Steven T. Pals   +7 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Neisserial PorB immune enhancing activity and use as a vaccine adjuvant

Human Vaccines & Immunotherapeutics, 2019
Our laboratory has focused on Porin B (PorB), an outer membrane protein from Neisseria meningitidis and TLR2 ligand-based adjuvant, to characterize specific molecular and cellular pathways involved in improved immune responses induced by vaccine ...
Rachel Yuen, Jeff Kuniholm, Christina Lisk, Lee M. Wetzler   +3 more
doaj   +1 more source

TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88. [PDF]

PLoS ONE, 2012
MyD88, a Toll/interleukin-1 receptor homology (TIR) domain-containing adaptor protein, mediates signals from the Toll-like receptors (TLR) or IL-1/IL-18 receptors to downstream kinases. In MyD88-dependent TLR4 signaling, the function of MyD88 is enhanced
Hidenori Ohnishi, Hidehito Tochio, Zenichiro Kato, Norio Kawamoto, Takeshi Kimura, Kazuo Kubota, Takahiro Yamamoto, Tatsuyoshi Funasaka, Hiroshi Nakano, Richard W Wong, Masahiro Shirakawa, Naomi Kondo   +11 more
doaj   +1 more source

Global analysis of gene expression reveals mRNA superinduction is required for the inducible immune response to a bacterial pathogen. [PDF]

, 2017
The inducible innate immune response to infection requires a concerted process of gene expression that is regulated at multiple levels. Most global analyses of the innate immune response have focused on transcription induced by defined immunostimulatory ...
Barry, Kevin C, Ingolia, Nicholas T, Vance, Russell E   +2 more
core   +3 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source