Results 1 to 10 of about 294,817 (379)
Overview of myelin, major myelin lipids, and myelin-associated proteins
Frontiers in Chemistry, 2023 Myelin is a modified cell membrane that forms a multilayer sheath around the axon. It retains the main characteristics of biological membranes, such as lipid bilayer, but differs from them in several important respects.
Alexander Kister, Ilya Kister
doaj +4 more sources
Myelin lipid metabolism and its role in myelination and myelin maintenance
The Innovation, 2023 Myelin is a specialized cell membrane indispensable for rapid nerve conduction. The high abundance of membrane lipids is one of myelin’s salient features that contribute to its unique role as an insulator that electrically isolates nerve fibers across ...
Joseph A. Barnes-Vélez +2 more
doaj +3 more sources
Anti-CD20 therapy depletes activated myelin-specific CD8+ T cells in multiple sclerosis. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2019 CD8+ T cells are believed to play an important role in multiple sclerosis (MS), yet their role in MS pathogenesis remains poorly defined. Although myelin proteins are considered potential autoantigenic targets, prior studies of myelin-reactive CD8+ T ...
Calabresi, Peter A +5 more
core +2 more sources
An interactive meta-analysis of MRI biomarkers of myelin
eLife, 2020 Several MRI measures have been proposed as in vivo biomarkers of myelin, each with applications ranging from plasticity to pathology. Despite the availability of these myelin-sensitive modalities, specificity and sensitivity have been a matter of ...
Matteo Mancini +5 more
doaj +2 more sources
The CNS Myelin Proteome: Deep Profile and Persistence After Post-mortem Delay
Frontiers in Cellular Neuroscience, 2020 Myelin membranes are dominated by lipids while the complexity of their protein composition has long been considered to be low. However, numerous additional myelin proteins have been identified since.
Olaf Jahn +8 more
doaj +2 more sources
Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease
Nature, 2023 Mouse models show that myelin dysfunction and associated inflammation increase with age, which can promote amyloid-β deposition and therefore risk of developing Alzheimer’s disease. The incidence of Alzheimer’s disease (AD), the leading cause of dementia,
Constanze Depp +29 more
semanticscholar +1 more source
Pharmaceuticals, 2021 Preclinical evidence, accumulated over the past decade, indicates that the angiotensin II type 2 receptor (AT2R) stimulation exerts significant neuroprotective effects in various animal models of neuronal injury, notably in the central nervous system ...
Aurore Danigo +9 more
doaj +1 more source
Microglia regulate central nervous system myelin growth and integrity
Nature, 2022 Resident microglia in the central nervous system are identified as the specific macrophage population that regulates myelin growth and integrity. Myelin is required for the function of neuronal axons in the central nervous system, but the mechanisms that
N. McNamara +27 more
semanticscholar +1 more source
The Metabolism of Myelin [PDF]
Proceedings of the Royal Society of Medicine, 1961 G. Payling Wright
openalex +4 more sources
Ramipril Alleviates Oxaliplatin-Induced Acute Pain Syndrome in Mice
Frontiers in Pharmacology, 2021 Oxaliplatin is a key drug for colorectal cancer that causes OXP-induced peripheral neuropathy, a dose-limiting effect characterized by cold and tactile hyperesthesia.
Hichem Bouchenaki +10 more
doaj +1 more source