Results 1 to 10 of about 295,157 (391)

Overview of myelin, major myelin lipids, and myelin-associated proteins

Frontiers in Chemistry, 2023
Myelin is a modified cell membrane that forms a multilayer sheath around the axon. It retains the main characteristics of biological membranes, such as lipid bilayer, but differs from them in several important respects.
Alexander Kister, Ilya Kister
doaj   +4 more sources

Myelin Pathology: Involvement of Molecular Chaperones and the Promise of Chaperonotherapy [PDF]

Brain Sciences, 2019
The process of axon myelination involves various proteins including molecular chaperones. Myelin alteration is a common feature in neurological diseases due to structural and functional abnormalities of one or more myelin proteins.
Federica Scalia, Antonella Marino Gammazza, Everly Conway de Macario, Alberto J. L. Macario, Francesco Cappello   +4 more
doaj   +3 more sources

The Angiotensin II Type 2 Receptor, a Target for Protection and Regeneration of the Peripheral Nervous System?

Pharmaceuticals, 2021
Preclinical evidence, accumulated over the past decade, indicates that the angiotensin II type 2 receptor (AT2R) stimulation exerts significant neuroprotective effects in various animal models of neuronal injury, notably in the central nervous system ...
Aurore Danigo, Amandine Rovini, Flavien Bessaguet, Hichem Bouchenaki, Amandine Bernard, Franck Sturtz, Sylvie Bourthoumieu, Alexis Desmoulière, Laurent Magy, Claire Demiot   +9 more
doaj   +1 more source

Ramipril Alleviates Oxaliplatin-Induced Acute Pain Syndrome in Mice

Frontiers in Pharmacology, 2021
Oxaliplatin is a key drug for colorectal cancer that causes OXP-induced peripheral neuropathy, a dose-limiting effect characterized by cold and tactile hyperesthesia.
Hichem Bouchenaki, Aurore Danigo, Amandine Bernard, Flavien Bessaguet, Laurence Richard, Laurence Richard, Franck Sturtz, David Balayssac, Laurent Magy, Laurent Magy, Claire Demiot   +10 more
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Ceruloplasmin deletion in myelinating glial cells induces myelin disruption and oxidative stress in the central and peripheral nervous systems

Redox Biology, 2021
Ceruloplasmin (Cp) is a ferroxidase enzyme that is essential for cell iron efflux and has been postulated to have a neuroprotective role. During the myelination process, oligodendrocytes (OLs) and Schwann cells (SCs) express high levels of Cp, but the ...
D.A. Santiago González, V.T. Cheli, S.L. Rosenblum, G. Denaroso, P.M. Paez   +4 more
doaj   +1 more source

ACER3-related leukoencephalopathy: expanding the clinical and imaging findings spectrum due to novel variants

Human Genomics, 2021
Background Leukodystrophies are the main subgroup of inherited CNS white matter disorders which cause significant mortality and morbidity in early years of life.
Ali Zare Dehnavi, Erfan Heidari, Maryam Rasulinezhad, Morteza Heidari, Mahmoud Reza Ashrafi, Mohammad Mahdi Hosseini, Fatemeh Sadeghzadeh, Mohammad-Sadegh Fallah, Noushin Rostampour, Amir Bahraini, Masoud Garshasbi, Ali Reza Tavasoli   +11 more
doaj   +1 more source

Deletion of voltage-gated calcium channels in astrocytes decreases neuroinflammation and demyelination in a murine model of multiple sclerosis

Journal of Neuroinflammation, 2023
The experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis was used in combination with a Cav1.2 conditional knock-out mouse (Cav1.2KO) to study the role of astrocytic voltage-gated Ca++ channels in autoimmune CNS inflammation and ...
G. E. Denaroso, Z. Smith, C. G. Angeliu, V. T. Cheli, C. Wang, P. M. Paez   +5 more
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Lanthionine Ketimine Ethyl Ester Accelerates Remyelination in a Mouse Model of Multiple Sclerosis

ASN Neuro, 2022
Although over 20 disease modifying therapies are approved to treat Multiple Sclerosis (MS), these do not increase remyelination of demyelinated axons or mitigate axon damage.
Jeffrey L. Dupree, Pablo M. Paez, Seema K. Tiwari-Woodruff, Travis T. Denton, Kenneth Hensley, Christina G. Angeliu, Anne I. Boullerne, Sergey Kalinin, Sophia Egge, Veronica T. Cheli, Giancarlo Denaroso, Kelley C. Atkinson, Micah Feri, Douglas L. Feinstein   +13 more
doaj   +1 more source

Proteome Profile of Myelin in the Zebrafish Brain

Frontiers in Cell and Developmental Biology, 2021
The velocity of nerve conduction along vertebrate axons depends on their ensheathment with myelin. Myelin membranes comprise specialized proteins well characterized in mice.
Sophie B. Siems, Olaf Jahn, Laura J. Hoodless, Ramona B. Jung, Dörte Hesse, Wiebke Möbius, Wiebke Möbius, Tim Czopka, Hauke B. Werner   +8 more
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Symptomatic care of late-onset Alexander disease presenting with area postrema-like syndrome with prednisolone; a case report

BMC Pediatrics, 2022
Background Alexander disease (AxD) is classified into AxD type I (infantile) and AxD type II (juvenile and adult form). We aimed to determine the potential genetic cause(s) contributing to the AxD type II manifestations in a 9-year-old male who presented
Safoura Zardadi, Ehsan Razmara, Maryam Rasoulinezhad, Meisam Babaei, Mohammad Reza Ashrafi, Neda Pak, Masoud Garshasbi, Ali Reza Tavasoli   +7 more
doaj   +1 more source