Results 1 to 10 of about 188,593 (222)

Overview of myelin, major myelin lipids, and myelin-associated proteins

Frontiers in Chemistry, 2023
Myelin is a modified cell membrane that forms a multilayer sheath around the axon. It retains the main characteristics of biological membranes, such as lipid bilayer, but differs from them in several important respects.
Alexander Kister, Ilya Kister
doaj   +2 more sources

Thinning of originally-existing, mature myelin represents a nondestructive form of myelin loss in the adult CNS. [PDF]

Front Cell Neurosci
The main function of oligodendrocytes is to assemble and maintain myelin that wraps and insulates axons in the central nervous system (CNS). Traditionally, myelin structure, particularly its thickness, was believed to remain remarkably stable in ...
Lin ML, Lin W.
europepmc   +2 more sources

The CNS Myelin Proteome: Deep Profile and Persistence After Post-mortem Delay

Frontiers in Cellular Neuroscience, 2020
Myelin membranes are dominated by lipids while the complexity of their protein composition has long been considered to be low. However, numerous additional myelin proteins have been identified since.
Olaf Jahn, Sophie B. Siems, Kathrin Kusch, Dörte Hesse, Ramona B. Jung, Thomas Liepold, Marina Uecker, Ting Sun, Hauke B. Werner   +8 more
doaj   +2 more sources

Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease

Nature, 2023
Mouse models show that myelin dysfunction and associated inflammation increase with age, which can promote amyloid-β deposition and therefore risk of developing Alzheimer’s disease. The incidence of Alzheimer’s disease (AD), the leading cause of dementia,
Constanze Depp, T. Sun, A. Sasmita, L. Spieth, Stefan A Berghoff, Taisiia Nazarenko, Katharina Overhoff, Agnes A. Steixner-Kumar, Swati Subramanian, Sahab Arinrad, T. Ruhwedel, W. Möbius, S. Göbbels, G. Saher, H. Werner, Alkmini Damkou, S. Zampar, O. Wirths, Maik Thalmann, M. Simons, T. Saito, T. Saido, Dilja Krueger-Burg, R. Kawaguchi, M. Willem, C. Haass, Daniel H. Geschwind, H. Ehrenreich, Ruth M. Stassart, K. Nave   +29 more
semanticscholar   +1 more source

The Angiotensin II Type 2 Receptor, a Target for Protection and Regeneration of the Peripheral Nervous System?

Pharmaceuticals, 2021
Preclinical evidence, accumulated over the past decade, indicates that the angiotensin II type 2 receptor (AT2R) stimulation exerts significant neuroprotective effects in various animal models of neuronal injury, notably in the central nervous system ...
Aurore Danigo, Amandine Rovini, Flavien Bessaguet, Hichem Bouchenaki, Amandine Bernard, Franck Sturtz, Sylvie Bourthoumieu, Alexis Desmoulière, Laurent Magy, Claire Demiot   +9 more
doaj   +1 more source

Microglia regulate central nervous system myelin growth and integrity

Nature, 2022
Resident microglia in the central nervous system are identified as the specific macrophage population that regulates myelin growth and integrity. Myelin is required for the function of neuronal axons in the central nervous system, but the mechanisms that
N. McNamara, David A. D. Munro, Nadine Bestard-Cuche, Akiko Uyeda, Jeroen F. J. Bogie, A. Hoffmann, Rebecca K. Holloway, Irene Molina-Gonzalez, Katharine E. Askew, Stephen Mitchell, W. Mungall, Michael Dodds, Carsten Dittmayer, J. Moss, Jamie L. Rose, S. Szymkowiak, Lukas Amann, B. McColl, M. Prinz, T. Spires-Jones, W. Stenzel, K. Horsburgh, Jerome J. A. Hendriks, Clare Pridans, R. Muramatsu, Anna C. Williams, J. Priller, V. Miron   +27 more
semanticscholar   +1 more source

Ramipril Alleviates Oxaliplatin-Induced Acute Pain Syndrome in Mice

Frontiers in Pharmacology, 2021
Oxaliplatin is a key drug for colorectal cancer that causes OXP-induced peripheral neuropathy, a dose-limiting effect characterized by cold and tactile hyperesthesia.
Hichem Bouchenaki, Aurore Danigo, Amandine Bernard, Flavien Bessaguet, Laurence Richard, Laurence Richard, Franck Sturtz, David Balayssac, Laurent Magy, Laurent Magy, Claire Demiot   +10 more
doaj   +1 more source

ACER3-related leukoencephalopathy: expanding the clinical and imaging findings spectrum due to novel variants

Human Genomics, 2021
Background Leukodystrophies are the main subgroup of inherited CNS white matter disorders which cause significant mortality and morbidity in early years of life.
Ali Zare Dehnavi, Erfan Heidari, Maryam Rasulinezhad, Morteza Heidari, Mahmoud Reza Ashrafi, Mohammad Mahdi Hosseini, Fatemeh Sadeghzadeh, Mohammad-Sadegh Fallah, Noushin Rostampour, Amir Bahraini, Masoud Garshasbi, Ali Reza Tavasoli   +11 more
doaj   +1 more source

Deletion of voltage-gated calcium channels in astrocytes decreases neuroinflammation and demyelination in a murine model of multiple sclerosis

Journal of Neuroinflammation, 2023
The experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis was used in combination with a Cav1.2 conditional knock-out mouse (Cav1.2KO) to study the role of astrocytic voltage-gated Ca++ channels in autoimmune CNS inflammation and ...
G. E. Denaroso, Z. Smith, C. G. Angeliu, V. T. Cheli, C. Wang, P. M. Paez   +5 more
doaj   +1 more source

Myelin: A gatekeeper of activity-dependent circuit plasticity?

Science, 2021
Description Insulation for circuit regulation Lipid-rich myelin, which wraps around and insulates neuronal axons, improves the speed and efficiency of signal propagation.
Giulia Bonetto, D. Belin, R. Káradóttir   +2 more
semanticscholar   +1 more source