Results 41 to 50 of about 188,742 (365)
Astrocytes and Microglia as Major Players of Myelin Production in Normal and Pathological Conditions
Frontiers in Cellular Neuroscience, 2020 Myelination is an essential process that consists of the ensheathment of axons by myelin. In the central nervous system (CNS), myelin is synthesized by oligodendrocytes. The proliferation, migration, and differentiation of oligodendrocyte precursor cells
E. Traiffort +3 more
semanticscholar +1 more source
An interactive meta-analysis of MRI biomarkers of myelin
bioRxiv, 2020 Several MRI measures have been proposed as in vivo biomarkers of myelin, each with applications ranging from plasticity to pathology. Despite the availability of these myelin-sensitive modalities, specificity and sensitivity have been a matter of ...
Matteo Mancini +5 more
semanticscholar +1 more source
Orphanet Journal of Rare Diseases, 2018 Background Infantile Sandhoff disease (ISD) is a GM2 gangliosidosis that is classified as a lysosomal storage disorder. The most common symptoms of affected individuals at presentation are neurologic involvement.
Ali Reza Tavasoli +5 more
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Identification of 3' UTR motifs required for mRNA localization to myelin sheaths in vivo.
PLoS Biology, 2021 Myelin is a specialized membrane produced by oligodendrocytes that insulates and supports axons. Oligodendrocytes extend numerous cellular processes, as projections of the plasma membrane, and simultaneously wrap multiple layers of myelin membrane around
Katie M Yergert +4 more
doaj +1 more source
Polyphosphoinositides in myelin [PDF]
Biochemical Journal, 1965 1. On fractionation of guinea-pig forebrain homogenates by differential and gradient-density centrifugation most of the polyphosphoinositides were recovered in the myelin-rich particles. 2. The phospholipids of pure preparations of myelin contained di- and tri-phosphoinositide in proportions 2-3 times greater than in the whole-brain phospholipids.
R. M. C. Dawson, Joseph Eichberg
openaire +3 more sources
Redox Biology, 2021 Ceruloplasmin (Cp) is a ferroxidase enzyme that is essential for cell iron efflux and has been postulated to have a neuroprotective role. During the myelination process, oligodendrocytes (OLs) and Schwann cells (SCs) express high levels of Cp, but the ...
D.A. Santiago González +4 more
doaj
Frontiers in Neuroscience, 2022 The development of neuronal circuitry required for cognition, complex motor behaviors, and sensory integration requires myelination. The role of glial cells such as astrocytes and microglia in shaping synapses and circuits have been covered in other ...
Daniela M. S. Moura +4 more
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Nanoscale correlated disorder in out-of-equilibrium myelin ultrastructure [PDF]
ACS Nano 12(1), 729-739 (2018), 2017 Ultrastructural fluctuations at nanoscale are fundamental to assess properties and functionalities of advanced out-of-equilibrium materials. We have taken myelin as a model of supramolecular assembly in out-of-equilibrium living matter. Myelin sheath is a simple stable multi-lamellar structure of high relevance and impact in biomedicine. Although it is
arxiv +1 more source
CD36-mediated uptake of myelin debris by macrophages and microglia reduces neuroinflammation
Journal of Neuroinflammation, 2020 Background The presence of foamy macrophages and microglia containing intracellular myelin remnants is a pathological hallmark of neurodegenerative disorders such as multiple sclerosis (MS).
Elien Grajchen +11 more
semanticscholar +1 more source
Frontiers in Neurology, 2018 Myelin sensitive MRI techniques, such as diffusion tensor imaging and myelin water imaging, have previously been used to reveal changes in myelin after sports-related concussions.
Alexander M. Weber +14 more
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