Regional analysis of myelin basic protein across postnatal brain development of C57BL/6J mice [PDF]
Frontiers in NeuroanatomyHealthy brain development hinges on proper myelination, with disruption contributing to a wide array of neurological disorders. Immunohistochemical analysis of myelin basic protein (MBP) is a fundamental technique for investigating myelination and ...
Siddhi S. Ozarkar +12 more
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Scientific Reports, 2017 Compact myelin comprises most of the dry weight of myelin, and its insulative nature is the basis for saltatory conduction of nerve impulses. The major dense line (MDL) is a 3-nm compartment between two cytoplasmic leaflets of stacked myelin membranes ...
Arne Raasakka +11 more
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Myelin Basic Protein and Cardiac Sympathetic Neurodegeneration in Nonhuman Primates [PDF]
Neurology Research International, 2021 Minimal myelination is proposed to be a contributing factor to the preferential nigral neuronal loss in Parkinson’s disease (PD). Similar to nigral dopaminergic neurons, sympathetic neurons innervating the heart have long, thin axons which are ...
Jeanette M. Metzger +8 more
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Molecular characterization of myelin basic protein a (mbpa) gene from red-bellied pacu (Piaractus brachypomus) [PDF]
Journal of Genetic Engineering and Biotechnology, 2022 Background Myelin basic protein (MBP) is one of the most important structural components of the myelin sheaths in both central and peripheral nervous systems. MBP has several functions including organization of the myelin membranes, reorganization of the
Juan Sebastian Cruz-Méndez +3 more
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Making Myelin Basic Protein -from mRNA transport to localized translation
Frontiers in Cellular Neuroscience, 2013 In the central nervous system (CNS) of most vertebrates, oligodendrocytes enwrap neuronal axons with extensions of their plasma membrane to form the myelin sheath. Several proteins are characteristically found in myelin of which Myelin Basic Protein (MBP)
Christina eMüller +3 more
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Myelin basic protein enhances axonal regeneration from neural progenitor cells [PDF]
Cell & Bioscience, 2021 Introduction Stem cell therapy using neural progenitor cells (NPCs) shows promise in mitigating the debilitating effects of spinal cord injury (SCI). Notably, myelin stimulates axonal regeneration from mammalian NPCs.
Zhengjian Yan +4 more
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Immunologic Properties of the Main Encephalitogenic Peptide from the Basic Protein of Human Myelin [PDF]
Journal of Immunology, 1970 The encephalitogenic basic protein from human brain was digested with pepsin and encephalitogenic peptides were isolated. Two overlapping peptides containing 15 and 22 amino acids had similar encephalitogenicity as the parent protein.
Vanda A. Lennon +2 more
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Phase-Dependent Adsorption of Myelin Basic Protein to Phosphatidylcholine Lipid Bilayers [PDF]
MembranesThe dense packing of opposite cytoplasmic surfaces of the lipid-enriched myelin membrane, responsible for the proper saltatory conduction of nerve impulses through axons, is ensured by the adhesive properties of myelin basic protein (MBP).
Petra Maleš +4 more
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Serum and Saliva Myelin Basic Protein as Multiple Sclerosis Biomarker [PDF]
Basic and Clinical Neuroscience, 2021 Introduction: Multiple Sclerosis (MS) is presented with motor and sensory function loss. It is caused by demyelination and following axonal lesion. As Myelin Basic Protein (MBP) is one of the key elements of the myelin cover, we examined the level of MBP
Mohammad Hossein Mirzaii-Dizgah +2 more
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Immunodominant fragments of myelin basic protein initiate T cell-dependent pain
Journal of Neuroinflammation, 2012 Background The myelin sheath provides electrical insulation of mechanosensory Aβ-afferent fibers. Myelin-degrading matrix metalloproteinases (MMPs) damage the myelin sheath.
Liu Huaqing +9 more
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