Results 21 to 30 of about 173,005 (318)

Nanoformulated Recombinant Human Myelin Basic Protein and Rituximab Modulate Neuronal Perturbations in Experimental Autoimmune Encephalomyelitis in Mice [PDF]

International Journal of Nanomedicine, 2022
Muhammed A Saad,1,2 Noha M Eissa,2 Mohammed A Ahmed,3 Aliaa N ElMeshad,3,4 Götz Laible,5– 7 Ahmed S Attia,8 Medhat A Al-Ghobashy,9,10 Rania M Abdelsalam,1,2 Muhammad Y Al-Shorbagy1,11 1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo
Saad MA, Eissa NM, Ahmed MA, ElMeshad AN, Laible G, Attia AS, Al-Ghobashy MA, Abdelsalam RM, Al-Shorbagy MY   +8 more
doaj   +2 more sources

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering. [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 1992
Oral administration of myelin basic protein (MBP) is an effective way of suppressing experimental autoimmune encephalomyelitis (EAE). We have previously shown that such suppression is mediated by CD8+ T cells, which adoptively transfer protection and ...
Ariel Miller, Ofer Lider, Anita B. Roberts, Michael B. Sporn, Howard L. Weiner   +4 more
openalex   +2 more sources

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain. [PDF]

Journal of Experimental Medicine, 1992
Experimental autoimmune encephalomyelitis (EAE) in the Lewis rat is a self-limited inflammatory process localized to the central nervous system that is induced by the injection of myelin basic protein (MBP) in adjuvant.
Samia J. Khoury, Wayne W. Hancock, Howard L. Weiner   +2 more
openalex   +2 more sources

Citrullinated isomer of myelin basic protein can induce inflammatory responses in astrocytes [PDF]

IBRO Neuroscience Reports
Purpose: During the course of demyelinating inflammatory diseases, myelin-derived proteins, including myelin basic protein(MBP), are secreted into extracellular space.
Marika Chikviladze, Nino Mamulashvili, Maia Sepashvili, Nana Narmania, Jeremy Ramsden, Lali Shanshiashvili, David Mikeladze   +6 more
doaj   +2 more sources

Dysregulation in Subcellular Localization of Myelin Basic Protein mRNA Does Not Result in Altered Myelination in Amyotrophic Lateral Sclerosis [PDF]

Frontiers in Neuroscience, 2021
Pathological hallmarks of amyotrophic lateral sclerosis (ALS), including protein misfolding, are well established in oligodendrocytes. More recently, an RNA trafficking deficit of key myelin proteins has been suggested in oligodendrocytes in ALS but the ...
Samantha K. Barton, Samantha K. Barton, Samantha K. Barton, Samantha K. Barton, Jenna M. Gregory, Jenna M. Gregory, Jenna M. Gregory, Bhuvaneish T. Selvaraj, Bhuvaneish T. Selvaraj, Bhuvaneish T. Selvaraj, Karina McDade, Karina McDade, Christopher M. Henstridge, Christopher M. Henstridge, Christopher M. Henstridge, Tara L. Spires-Jones, Tara L. Spires-Jones, Tara L. Spires-Jones, Owen G. James, Owen G. James, Owen G. James, Arpan R. Mehta, Arpan R. Mehta, Arpan R. Mehta, David Story, David Story, David Story, Karen Burr, Karen Burr, Karen Burr, Dario Magnani, Dario Magnani, Dario Magnani, Adrian M. Isaacs, Adrian M. Isaacs, Colin Smith, Colin Smith, Siddharthan Chandran, Siddharthan Chandran, Siddharthan Chandran   +39 more
doaj   +2 more sources

Myelin basic protein: a multifunctional protein

Cellular and Molecular Life Sciences, 2006
Myelin basic protein (MBP), the second most abundant protein in central nervous system myelin, is responsible for adhesion of the cytosolic surfaces of multilayered compact myelin. A member of the 'intrinsically disordered' or conformationally adaptable protein family, it also appears to have several other functions.
J. Boggs, J. Boggs
semanticscholar   +4 more sources

SncRNA715 Inhibits Schwann Cell Myelin Basic Protein Synthesis. [PDF]

PLoS ONE, 2015
Myelin basic proteins (MBP) are major constituents of the myelin sheath in the central nervous system (CNS) and the peripheral nervous system (PNS). In the CNS Mbp translation occurs locally at the axon-glial contact site in a neuronal activity-dependent
Christina Müller, Nina M Hochhaus, Xavier Fontana, Heiko J Luhmann, Robin White   +4 more
doaj   +1 more source

Enzymic methylation of myelin basic protein in myelin [PDF]

Biochemical Journal, 1991
Myelin fractions with different degrees of compaction were isolated from bovine brain, and post-translational methylation of membrane-associated proteins was studied. When the purified myelin-basic-protein-specific protein methylase I and S-adenosyl-L-[methyl-14C]methionine were added exogenously, the most compact myelin fraction exhibited higher ...
N Rawal, Soochong Kim, S K Syed, Woon Ki Paik, S K Ghosh   +4 more
openaire   +3 more sources

Proteome Profile of Myelin in the Zebrafish Brain

Frontiers in Cell and Developmental Biology, 2021
The velocity of nerve conduction along vertebrate axons depends on their ensheathment with myelin. Myelin membranes comprise specialized proteins well characterized in mice.
Sophie B. Siems, Olaf Jahn, Laura J. Hoodless, Ramona B. Jung, Dörte Hesse, Wiebke Möbius, Wiebke Möbius, Tim Czopka, Hauke B. Werner   +8 more
doaj   +1 more source

Overview of myelin, major myelin lipids, and myelin-associated proteins

Frontiers in Chemistry, 2023
Myelin is a modified cell membrane that forms a multilayer sheath around the axon. It retains the main characteristics of biological membranes, such as lipid bilayer, but differs from them in several important respects.
Alexander Kister, Ilya Kister
doaj   +1 more source