Results 31 to 40 of about 173,005 (318)

Lipid and basic protein interaction in myelin [PDF]

Biochemical Journal, 1974
1. Purified myelin labelled with [3H]myo-inositol or [1-14C]acetate was incubated with trypsin or acetylated trypsin at 37°C, pH8.0 for 30min. 2. After incubation and centrifugation analysis of the myelin pellet showed marked digestion of basic protein on polyacrylamide-gel electrophoresis. Proteolipid and Wolfgram proteins remained unchanged. 3.
Naren L. Banik, Alan N. Davison
openaire   +3 more sources

Phosphorylation of Myelin Basic Protein

Journal of Biological Chemistry, 1974
Myelin membranes prepared from rat brain possess both the enzyme and substrates to incorporate 32P from [γ-32P]ATP into membrane protein constituents. Of the myelin polypeptides, only the two basic proteins were phosphorylated; and both components appeared to be equally good substrates for endogenous or added protein kinases.
Andreas J. Steck, Stanley H. Appel
openaire   +3 more sources

Translational Control of Myelin Basic Protein Expression by ERK2 MAP Kinase Regulates Timely Remyelination in the Adult Brain

Journal of Neuroscience, 2015
Successful myelin repair in the adult CNS requires the robust and timely production of myelin proteins to generate new myelin sheaths. The underlying regulatory mechanisms and complex molecular basis of myelin regeneration, however, remain poorly ...
Kelly Michel, Tianna Zhao, Molly Karl, K. Lewis, Sharyl L Fyffe-Maricich   +4 more
semanticscholar   +1 more source

Age-dependent differences in myelin basic protein expression in the hippocampus of young, adult and aged gerbils

Laboratory Animal Research, 2017
Myelin degeneration is one of the characteristics of aging and degenerative diseases. This study investigated age-related alterations in expression of myelin basic protein (MBP) in the hippocampal subregions (dentate gyrus, CA2/3 and CA1 areas) of ...
Ji Hyeon Ahn, Tae-Kyeong Lee, Joon Ha Park, Jeong Hwi Cho, In Hye Kim, Jae Chul Lee, Seongkweon Hong, Yong Hwan Jeon, Il Jun Kang, Young Joo Lee, Moo-Ho Won, Choong-Hyun Lee   +11 more
doaj   +1 more source

Central and peripheral dysmyelination in a 3‐year‐old girl with ring chromosome 18

Clinical Case Reports, 2019
Myelin basic protein (MBP) contributes to peripheral and central nervous system myelin. Developmental myelinopathies exist on a clinical spectrum, but MBP is not included on leukodystrophy or CMT gene panels.
Dawn Brianna Lammert, David Miedema, Josiree Ochotorena, Nienke Dosa, Kalliopi Petropoulou, Roger Robert Lebel, Ai Sakonju   +6 more
doaj   +1 more source

CONTENTS OF SERUM MYELIN BASIC PROTEIN-IGG ANTIBODIES COMPLEXES IN NORMAL PREGNANCY AND GESTOSIS

Медицинская иммунология, 2014
Serum levels of myelin basic protein (MBP)-bound immune complexes were studied in blood sera from women with gestosis, as compared with those in normal pregnancy and non-pregnant woman.
V. G. Levchenko, N. V. Maltseva, O. F. Lykova, T. V. Konysheva, V. N. Zorina   +4 more
doaj   +1 more source

Autophagic degradation of CNS myelin maintains axon integrity

Cell Stress, 2022
(Macro)autophagy is a major lysosome-dependent degradation mechanism which engulfs, removes and recycles unwanted cytoplasmic material, including damaged organelles and toxic protein aggregates.
Niki Ktena, Stefanos Ioannis Kaplanis, Irina Kolotuev, Alexandros Georgilis, Emmanouela Kallergi, Vasiliki Stavroulaki, Vassiliki Nikoletopoulou, Maria Savvaki, Domna Karagogeos   +8 more
doaj   +1 more source

How Does Protein Zero Assemble Compact Myelin?

Cells, 2020
Myelin protein zero (P0), a type I transmembrane protein, is the most abundant protein in peripheral nervous system (PNS) myelin—the lipid-rich, periodic structure of membrane pairs that concentrically encloses long axonal segments.
Arne Raasakka, Petri Kursula
doaj   +1 more source

Age-Related Changes of Myelin Basic Protein in Mouse and Human Auditory Nerve

PLoS ONE, 2012
Age-related hearing loss (presbyacusis) is the most common type of hearing impairment. One of the most consistent pathological changes seen in presbyacusis is the loss of spiral ganglion neurons (SGNs).
Y. Xing, D. Samuvel, Shawn M. Stevens, J. Dubno, B. A. Schulte, H. Lang   +5 more
semanticscholar   +1 more source

Endogenous interferon-β-inducible gene expression and interferon-β-treatment are associated with reduced T cell responses to myelin basic protein in multiple sclerosis.

PLoS ONE, 2015
Autoreactive CD4+ T-cells are considered to play a major role in the pathogenesis of multiple sclerosis. In experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis, exogenous and endogenous type I interferons restrict disease ...
Lars Börnsen, Jeppe Romme Christensen, Rikke Ratzer, Chris Hedegaard, Helle B Søndergaard, Martin Krakauer, Dan Hesse, Claus H Nielsen, Per S Sorensen, Finn Sellebjerg   +9 more
doaj   +1 more source