Results 41 to 50 of about 107,221 (257)
Assessment of concurrent neoplasms and a paraneoplastic association in MOGAD
Annals of Clinical and Translational Neurology, EarlyView.Abstract Cases of myelin oligodendrocyte glycoprotein (MOG) antibody‐associated disease (MOGAD) co‐occurring with neoplasms have been reported. In this international, retrospective cohort study in South Korea and the USA, 16 of 445 (3.6%) patients with MOGAD had concurrent neoplasm within 2 years of MOGAD onset, resulting in a standardized incidence ...
Young Nam Kwon +24 more
wiley +1 more source
Glia, Volume 71, Issue 2, Page 415-430, February 2023., 2023 Main Points A subset of OPCs do not express Olig2, of which population peaks in the juvenile brain while wanes with age. Plastic changes of the brain by acute injuries or complex motor learning stop the expression of Olig2 in OPCs. Abstract Oligodendrocyte precursor cells (OPCs) are uniformly distributed in the mammalian brain; however, their function ...
Li‐Pao Fang +7 more
wiley +1 more source
Introduction to Protein Structure [PDF]
arXiv, 2023 While many good textbooks are available on Protein Structure, Molecular Simulations, Thermodynamics and Bioinformatics methods in general, there is no good introductory level book for the field of Structural Bioinformatics. This book aims to give an introduction into Structural Bioinformatics, which is where the previous topics meet to explore three ...
arxiv
Engineering the Future of Restorative Clinical Peripheral Nerve Surgery
Advanced Healthcare Materials, EarlyView.What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell +5 more
wiley +1 more source
Independent SE(3)-Equivariant Models for End-to-End Rigid Protein Docking [PDF]
Spotlight at ICLR 2022: International Conference on Learning
Representations, 2021 Protein complex formation is a central problem in biology, being involved in most of the cell's processes, and essential for applications, e.g. drug design or protein engineering. We tackle rigid body protein-protein docking, i.e., computationally predicting the 3D structure of a protein-protein complex from the individual unbound structures, assuming ...
arxiv
Insights on Advances in 3D Bioprinting for Peripheral Nerve Regeneration
Advanced Therapeutics, EarlyView.Peripheral nerve injury is a common condition due to trauma that significantly impacts the life of the affected individual. This review explores the anatomy, classification, and pathophysiology of peripheral nerve injuries. It also discusses various types of nerve conduits and presents a detailed review of 3D bioprinted nerve conduits used in both in ...
Nasera Rizwana +5 more
wiley +1 more source
Scientific Reports, 2017 Compact myelin comprises most of the dry weight of myelin, and its insulative nature is the basis for saltatory conduction of nerve impulses. The major dense line (MDL) is a 3-nm compartment between two cytoplasmic leaflets of stacked myelin membranes ...
Arne Raasakka +11 more
doaj +1 more source
Growing ecosystem of deep learning methods for modeling protein$\unicode{x2013}$protein interactions [PDF]
arXiv, 2023 Numerous cellular functions rely on protein$\unicode{x2013}$protein interactions. Efforts to comprehensively characterize them remain challenged however by the diversity of molecular recognition mechanisms employed within the proteome. Deep learning has emerged as a promising approach for tackling this problem by exploiting both experimental data and ...
arxiv
α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model
Advanced Science, EarlyView.A novel midbrain–hindbrain assembloid model demonstrates the spread of α‐synuclein pathology, a hallmark of Parkinson's disease, mimicking Braak's hypothesis. This model reveals how pathology propagates from the hindbrain to the midbrain, inducing synaptic changes and early signs of neuronal vulnerability. It offers an innovative platform for exploring
Gemma Gomez‐Giro +14 more
wiley +1 more source
Advanced Science, EarlyView.By investigating auditory hyperexcitability in a mouse model for hereditary deafness, this study identified a subpopulation of afferent neurons of the auditory nerve marked by Otogl expression. Despite their apparently normal hearing, Otogl+/− mice display poor activation of afferent neurons processing loud sounds and an elevation of the middle the ear
Mathilde Gagliardini +24 more
wiley +1 more source