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Overview of myelin, major myelin lipids, and myelin-associated proteins
Frontiers in Chemistry, 2023 Myelin is a modified cell membrane that forms a multilayer sheath around the axon. It retains the main characteristics of biological membranes, such as lipid bilayer, but differs from them in several important respects.
Alexander Kister, Ilya Kister
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Brain Sciences, 2022 Myelin in humans is composed of about 80% lipids and 20% protein. Initially, myelin protein composition was considered low, but various recent proteome analyses have identified additional myelin proteins.
Christos T. Chasapis +4 more
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Proteome Profile of Myelin in the Zebrafish Brain
Frontiers in Cell and Developmental Biology, 2021 The velocity of nerve conduction along vertebrate axons depends on their ensheathment with myelin. Myelin membranes comprise specialized proteins well characterized in mice.
Sophie B. Siems +8 more
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Proteomic analysis of peripheral nerve myelin during murine aging
Frontiers in Cellular Neuroscience, 2023 Aging of the peripheral nervous system (PNS) is associated with structural and functional changes that lead to a reduction in regenerative capacity and the development of age-related peripheral neuropathy.
Dario Lucas Helbing +13 more
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eLife, 2022 Human myelin disorders are commonly studied in mouse models. Since both clades evolutionarily diverged approximately 85 million years ago, it is critical to know to what extent the myelin protein composition has remained similar.
Vasiliki-Ilya Gargareta +12 more
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The CNS Myelin Proteome: Deep Profile and Persistence After Post-mortem Delay
Frontiers in Cellular Neuroscience, 2020 Myelin membranes are dominated by lipids while the complexity of their protein composition has long been considered to be low. However, numerous additional myelin proteins have been identified since.
Olaf Jahn +8 more
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Mechanical Responses of a Single Myelin Layer: A Molecular Simulation Study
Biomolecules, 2023 The myelin sheath provides insulation to the brain’s neuron cells, which aids in signal transmission and communication with the body. Degenerated myelin hampers the connection between the glial cells, which are the front row responders during traumatic ...
Fairuz Maliha, Ashfaq Adnan
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Enzymic methylation of myelin basic protein in myelin [PDF]
Biochemical Journal, 1991 Myelin fractions with different degrees of compaction were isolated from bovine brain, and post-translational methylation of membrane-associated proteins was studied. When the purified myelin-basic-protein-specific protein methylase I and S-adenosyl-L-[methyl-14C]methionine were added exogenously, the most compact myelin fraction exhibited higher ...
S K, Ghosh +4 more
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Life, 2023 In elaborating and maintaining myelin sheaths on multiple axons/segments, oligodendrocytes distribute translation of some proteins, including myelin basic protein (MBP), to sites of myelin sheath assembly, or MSAS.
Robert Gould, Scott Brady
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Molecular Mimicry of SARS-CoV-2 Spike Protein in the Nervous System: A Bioinformatics Approach
Computational and Structural Biotechnology Journal, 2022 Introduction: The development of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in record time to cope with the ongoing coronavirus disease 2019 (COVID-19) pandemic has led to uncertainty about their use and the appearance ...
Andrés Felipe Cuspoca +2 more
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