Journal of Neuroscience, 2011 Peripheral nerve myelin facilitates rapid impulse conduction and normal motor and sensory functions. Many aspects of myelin biogenesis, glia–axonal interactions, and nerve homeostasis are poorly understood at the molecular level.
J. Patzig +16 more
semanticscholar +1 more source
A Myelin Proteolipid Protein-LacZ Fusion Protein Is Developmentally Regulated and Targeted to the Myelin Membrane in Transgenic Mice [PDF]
, 1993 Transgenic mice were generated with a fusion gene carrying a portion of the murine myelin proteolipid protein (PLP) gene, including the first intron, fused to the E. coli LacZ gene.
Duchala, Cynthia S. +3 more
core +2 more sources
MAG, myelin and overcoming growth inhibition in the CNS.
Frontiers in Molecular Neuroscience, 2015 While neurons in the central nervous system have the capacity to regenerate their axons after injury, they fail to do so, in part because regeneration is limited by growth inhibitory proteins present in CNS myelin.
Lisa eMcKerracher +2 more
doaj +1 more source
Recent Advances in Antigen-Specific Immunotherapies for the Treatment of Multiple Sclerosis
Brain Sciences, 2020 Multiple sclerosis (MS) is an autoimmune disease of the central nervous system and is considered to be the leading non-traumatic cause of neurological disability in young adults.
Olga Kammona, Costas Kiparissides
doaj +1 more source
Co-cultures with stem cell-derived human sensory neurons reveal regulators of peripheral myelination [PDF]
, 2017 Effective bidirectional signalling between axons and Schwann cells is essential for both the development and maintenance of peripheral nerve function. We have established conditions by which human induced pluripotent stem cell-derived sensory neurons can
Bennett, David L.H. +5 more
core +2 more sources
Emergence of three myelin proteins in oligodendrocytes cultured without neurons
Journal of Cell Biology, 1986 Oligodendrocytes, the myelin-forming cells of the central nervous system, were cultured from newborn rat brain and optic nerve to allow us to analyze whether two transmembranous myelin proteins, myelin- associated glycoprotein (MAG) and proteolipid ...
M. Dubois‐Dalcq +3 more
semanticscholar +1 more source
The Multiple Roles of Myelin Protein Genes During the Development of the Oligodendrocyte
ASN Neuro, 2009 It has become clear that the products of several of the earliest identified myelin protein genes perform functions that extend beyond the myelin sheath. Interestingly, these myelin proteins, which comprise proteolipid protein, 2′, 3′-cyclic nucleotide 3′-
Daniel Fulton +2 more
doaj +1 more source
Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination. [PDF]
, 2011 Permanent damage to white matter tracts, comprising axons and myelinating oligodendrocytes, is an important component of brain injuries of the newborn that cause cerebral palsy and cognitive disabilities, as well as multiple sclerosis in adults. However,
Baranzini, Sergio E +11 more
core +3 more sources
Myelin activates FAK/Akt/NF-kappaB pathways and provokes CR3-dependent inflammatory response in murine system. [PDF]
PLoS ONE, 2010 Inflammatory response following central nervous system (CNS) injury contributes to progressive neuropathology and reduction in functional recovery. Axons are sensitive to mechanical injury and toxic inflammatory mediators, which may lead to demyelination.
Xin Sun +11 more
doaj +1 more source
Neurology International, 2021 Hypomyelinating leukodystrophy 7 (HLD7) is an autosomal recessive oligodendroglial cell-related myelin disease, which is associated with some nucleotide mutations of the RNA polymerase 3 subunit a (polr3a) gene.
Sui Sawaguchi +7 more
doaj +1 more source