Results 31 to 40 of about 5,787,020 (354)

Structure of myelin P2 protein from equine spinal cord [PDF]

, 2005
Equine P2 protein has been isolated from horse spinal cord and its structure determined to 2.1 Å. Since equine myelin is a viable alternative to bovine tissue for large-scale preparations, characterization of the proteins from equine spinal cord ...
Freer, A.A., Griffiths, I.R., Hunter, D.J.B., Macmaster, R., Riboldi-Tunnicliffe, A., Roszak, A.W.   +5 more
core   +1 more source

Placental Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Myelin Regeneration in an Animal Model of Multiple Sclerosis. [PDF]

, 2019
Mesenchymal stem/stromal cells (MSCs) display potent immunomodulatory and regenerative capabilities through the secretion of bioactive factors, such as proteins, cytokines, chemokines as well as the release of extracellular vesicles (EVs).
Barthe, Sylvain, Clark, Kaitlin, Farmer, Diana, Guo, Fuzheng, Kreutzberg, Nicole, Kumar, Priyadarsini, Paxton, Zachary, Pivetti, Christopher, Reed, Camille, Wang, Aijun, Wang, Yan, Zhang, Sheng   +11 more
core   +2 more sources

Gpr126/Adgrg6 has Schwann cell autonomous and nonautonomous functions in peripheral nerve injury and repair [PDF]

, 2016
Schwann cells (SCs) are essential for proper peripheral nerve development and repair, although the mechanisms regulating these processes are incompletely understood.
Carlin, Dan, Cavalli, Valeria, Harty, Breanne L, Joseph, Jessica, Mogha, Amit, Monk, Kelly R, Piao, Xianhua, Sanchez, Nicholas E, Suter, Ueli   +8 more
core   +2 more sources

Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases

Cell Reports, 2016
Breakdown of myelin sheaths is a pathological hallmark of several autoimmune diseases of the nervous system. We employed autoantibody-mediated animal models of demyelinating diseases, including a rat model of neuromyelitis optica (NMO), to target myelin ...
Marie-Theres Weil, Wiebke Möbius, Anne Winkler, Torben Ruhwedel, Claudia Wrzos, Elisa Romanelli, Jeffrey L. Bennett, Lukas Enz, Norbert Goebels, Klaus-Armin Nave, Martin Kerschensteiner, Nicole Schaeren-Wiemers, Christine Stadelmann, Mikael Simons   +13 more
doaj   +1 more source

Compromised Myelin and Axonal Molecular Organization Following Adult-Onset Sulfatide Depletion

Biomedicines, 2023
3-O-sulfogalactosylceramide, or sulfatide, is a prominent myelin glycosphingolipid reduced in the normal appearing white matter (NAWM) in Multiple Sclerosis (MS), indicating that sulfatide reduction precedes demyelination.
Elizabeth Dustin, Edna Suarez-Pozos, Camryn Stotesberry, Shulan Qiu, Juan Pablo Palavicini, Xianlin Han, Jeffrey L. Dupree   +6 more
doaj   +1 more source

Severe central nervous system demyelination in Sanfilippo disease

Frontiers in Molecular Neuroscience, 2023
IntroductionChronic progressive neuroinflammation is a hallmark of neurological lysosomal storage diseases, including mucopolysaccharidosis III (MPS III or Sanfilippo disease).
Mahsa Taherzadeh, Mahsa Taherzadeh, Erjun Zhang, Irene Londono, Benjamin De Leener, Benjamin De Leener, Sophie Wang, Jonathan D. Cooper, Timothy E. Kennedy, Timothy E. Kennedy, Carlos R. Morales, Zesheng Chen, Gregory A. Lodygensky, Alexey V. Pshezhetsky, Alexey V. Pshezhetsky   +14 more
doaj   +1 more source

Nanoscale correlated disorder in out-of-equilibrium myelin ultrastructure

, 2017
Ultrastructural fluctuations at nanoscale are fundamental to assess properties and functionalities of advanced out-of-equilibrium materials. We have taken myelin as a model of supramolecular assembly in out-of-equilibrium living matter.
Bianconi, Antonio, Burghammer, Manfred, Campi, Gaetano, Ciasca, Gabriele, Di Gioacchino, Michael, Poccia, Nicola, Ricci, Alessandro   +6 more
core   +1 more source

Characterization of immune response to neurofilament light in experimental autoimmune encephalomyelitis [PDF]

, 2013
PMCID: PMC3856490This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided ...
Amor, S, Baker, D, Beyer, C, Gerritsen, W, Huizinga, R, Kipp, M, Peferoen-Baert, R, Pryce, G, Puentes, F, Reijerkerk, A, Ummenthum, K, van der Star, BJ, van der Valk, P, Victor, M   +13 more
core   +5 more sources

Proteomics of the corpus callosum to identify novel factors involved in hypomyelinated Niemann-Pick Type C disease mice

Molecular Brain, 2019
Hypomyelination in the central nerves system (CNS) is one of the most obviously pathological features in Niemann-Pick Type C disease (NPC), which is a rare neurodegenerative disorder caused by mutations in the NPC intracellular cholesterol transporter 1 ...
Fan Yang, Yudong Guan, Xiao Feng, Arndt Rolfs, Hartmut Schlüter, Jiankai Luo   +5 more
doaj   +1 more source

Myelin organization in the nodal, paranodal, and juxtaparanodal regions revealed by scanning x-ray microdiffraction. [PDF]

PLoS ONE, 2014
X-ray diffraction has provided extensive information about the arrangement of lipids and proteins in multilamellar myelin. This information has been limited to the abundant inter-nodal regions of the sheath because these regions dominate the scattering ...
Hideyo Inouye, Jiliang Liu, Lee Makowski, Marilena Palmisano, Manfred Burghammer, Christian Riekel, Daniel A Kirschner   +6 more
doaj   +1 more source