Results 91 to 100 of about 6,136 (180)

Correlation Between Anti-Myelin Proteolipid Protein (PLP) Antibodies and Disease Severity in Multiple Sclerosis Patients With PLP Response-Permissive HLA Types

Frontiers in Immunology, 2020
The most prominent pathological features of multiple sclerosis (MS) are demyelination and neurodegeneration. The exact pathogenesis of MS is unknown, but it is generally regarded as a T cell-mediated autoimmune disease.
Judith M. Greer, Elisabeth Trifilieff, Elisabeth Trifilieff, Michael P. Pender, Michael P. Pender   +4 more
doaj   +1 more source

Central Dysmyelination in SSADH‐Deficient Humans and Mice

Annals of Clinical and Translational Neurology, Volume 12, Issue 11, Page 2193-2205, November 2025.
ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer, Henry H. C. Lee, Edward Yang, Cesar Alves, Mariarita Bertoldi, Caitlyn Fung, Spencer V. Steele, Eren Kule, Zijie Jin, Alexander Rotenberg, Jean‐Baptiste Roullet, Phillip L. Pearl   +11 more
wiley   +1 more source

Naturally Occurring Nervonic Acid Ester Improves Myelin Synthesis by Human Oligodendrocytes

Cells, 2019
The dysfunction of oligodendrocytes (OLs) is regarded as one of the major causes of inefficient remyelination in multiple sclerosis, resulting gradually in disease progression.
Natalia Lewkowicz, Paweł Piątek, Magdalena Namiecińska, Małgorzata Domowicz, Radosław Bonikowski, Janusz Szemraj, Patrycja Przygodzka, Mariusz Stasiołek, Przemysław Lewkowicz   +8 more
doaj   +1 more source

Temporal and partial inhibition of GLI1 in neural stem cells (NSCs) results in the early maturation of NSC derived oligodendrocytes in vitro. [PDF]

, 2019
BackgroundOligodendrocytes are a type of glial cells that synthesize the myelin sheath around the axons and are critical for the nerve conduction in the CNS.
Biswas, Sangita, Chechneva, Olga, Deng, Wenbin, Mayrhofer, Florian, Namchaiw, Poommaree, Wen, Han   +5 more
core  

Extracellular Vesicles From Multiple Sclerosis White Matter Exhibit Synaptic, Mitochondrial, Complement and Ageing‐Related Pathway Dysregulation

Journal of Extracellular Vesicles, Volume 14, Issue 11, November 2025.
This study characterizes extracellular vesicles (EVs) separated from postmortem normal‐appearing white matter of multiple sclerosis (MS) and control brains. Proteomic analysis revealed downregulation of synaptic and mitochondrial, and upregulation of complement and inflammatory pathways, suggesting EVs reflect and may contribute to synaptic pathology ...
Larissa Jank, Madathiparambil Kumaran Satheesh Kumar, Taekyung Ryu, Rohit Thapa, Olesia Gololobova, Timothy D. Niepokny, Peter A. Calabresi, Kenneth Witwer, Ranjan Dutta, Chan Hyun Na, Pavan Bhargava   +10 more
wiley   +1 more source

SJL Mice Infected with Acanthamoeba castellanii Develop Central Nervous System Autoimmunity through the Generation of Cross-Reactive T Cells for Myelin Antigens [PDF]

, 2014
We recently reported that Acanthamoeba castellanii (ACA), an opportunistic pathogen of the central nervous system (CNS) possesses mimicry epitopes for proteolipid protein (PLP) 139–151 and myelin basic protein 89–101, and that the epitopes induce ...
da Rocha-Azevedo, Bruno, Gangaplara, Arunakumar, Illes, Zsolt, Jamerson, Melissa, Marciano-Cabral, Francine, Massilamany, Chandirasegaran, Reddy, Jay, Sobel, Raymond A., Steffen, David, Zabad, Rana   +9 more
core   +1 more source

Blood-Brain Barrier Disruption And Lesion Localisation In Experimental Autoimmune Encephalomyelitis With Predominant Cerebellar And Brainstem Involvement [PDF]

, 2005
The role of the blood-brain barrier (BBB) in determining lesion distribution was assessed in an atypical model of experimental autoimmune encephalomyelitis (EAE) induced in C3H/HeJ mice by immunisation with peptide 190-209 of myelin proteolipid protein ...
Greer, Judith M., Muller, Diane M., Pender, Michael P.   +2 more
core   +2 more sources

Complement dysregulation in human tauopathies

Brain Pathology, Volume 35, Issue 6, November 2025.
Complement protein and activation product levels were assessed in post‐mortem frontal cortex from three distinct subtypes of Tauopathy: Corticobasal degeneration, globular glial tauopathy, and Pick's disease. Quantification of complement proteins by immunohistochemistry and ELISA showed elevation of key complement proteins (C1q) regulators (FI) and ...
Jacqui Nimmo, Samuel Keat, Louis De Muynck, B. Paul Morgan   +3 more
wiley   +1 more source

Rapid Changes in Cholinergic Signaling, Myelination, and Thyroid Signaling Pathway Gene Expression in Amygdala Subnuclei in Response to Social Status Maintenance and Reorganization

European Journal of Neuroscience, Volume 62, Issue 9, November 2025.
ABSTRACT Male CD‐1 mice form linear social hierarchies and can rapidly reform them following social reorganization. Through tag‐based sequencing in the medial amygdala (MeA), we identified several genes regulating cholinergic signaling, myelination, and thyroid signaling that rapidly shift expression 70 min after animals change social status.
Tyler M. Milewski, Won Lee, Köll R. Rada, James P. Curley   +3 more
wiley   +1 more source

Integrated stress response inhibition prolongs the lifespan of a Pelizaeus-Merzbacher disease mouse model by increasing oligodendrocyte survival

Nature Communications
The leukodystrophy Pelizaeus-Merzbacher disease (PMD) is caused by myelin protein proteolipid protein gene (PLP1) mutations. PMD is characterized by oligodendrocyte death and CNS hypomyelination; thus, increasing oligodendrocyte survival and enhancing ...
Yanan Chen, Rejani B. Kunjamma, Karin Lin, Li Kai, Maria Dima, Kody Bruce, Ian Steckler, Young Hyun Che, Jason Chan-Zervas, Jaime Eugenin von Bernhardi, Caitlin Connelly, Sude Ece, Grace Newell, Dwight E. Bergles, Carmela Sidrauski, Brian Popko   +15 more
doaj   +1 more source