Results 41 to 50 of about 6,136 (180)

Very large G protein-coupled receptor 1 regulates myelin-associated glycoprotein via Gαs/Gαq-mediated protein kinases A/C. [PDF]

, 2013
VLGR1 (very large G protein-coupled receptor 1), also known as MASS1 (monogenic audiogenic seizure susceptible 1), is an orphan G protein-coupled receptor that contains a large extracellular N terminus with 35 calcium-binding domains.
Fu, Ying-Hui, Lin, Shu-Ting, Ptácek, Louis J, Shin, Daesung   +3 more
core   +1 more source

YY1 Negatively Regulates Mouse Myelin Proteolipid Protein () Gene Expression in Oligodendroglial Cells

ASN Neuro, 2011
YY1 (Yin and Yang 1) is a multifunctional, ubiquitously expressed, zinc finger protein that can act as a transcriptional activator, repressor, or initiator element binding protein.
Olga E Zolova, Patricia A Wight
doaj   +1 more source

Increased circulating T cell reactivity to GM3 and GQ1b gangliosides in primary progressive multiple sclerosis [PDF]

, 2003
We have previously shown that patients with primary progressive multiple sclerosis (MS) have significantly elevated plasma levels of antibody to GM3 ganglioside compared to patients with relapsing-remitting MS, healthy subjects and patients with other ...
Acarin, Arnon, Baba, Bech, Beraud, Chiba, Endo, Feix, Greer, Greer, Ho, Ilyas, Judith M Greer, Kasai, Kaye D Hooper, Kracun, Kusunoki, Lublin, Markovic-Plese, Martin, Mata, McDonald, Michael F Good, Michael P Pender, Moody, Mullin, Nigel P Wolfe, Offner, Offner, Pamela A McCombe, Pender, Pender, Pender, Peter A Csurhes, Poser, Rees, Sadatipour, Shamshiev, Stevens   +38 more
core   +1 more source

Preliminary Evidence of Increased Hippocampal Myelin Content in Veterans with Posttraumatic Stress Disorder. [PDF]

, 2015
Recent findings suggest the formation of myelin in the central nervous system by oligodendrocytes is a continuous process that can be modified with experience.
Chao, Linda L, Kaufer, Daniela, Neylan, Thomas C, Tosun, Duygu, Woodward, Steven H   +4 more
core   +1 more source

Endogenous Repair in Vanishing White Matter

Annals of Neurology, EarlyView.
Objective Vanishing white matter is a leukodystrophy with remarkable regional variation in disease severity. The cerebral and cerebellar white matter chronically degenerates, while stress‐induced episodes of rapid neurological deterioration coincide with the appearance of acute focal lesions in the deep gray structures and brainstem.
Bonnie C. Plug, Jodie H.K. Man, Marjolein Breur, Erik Nutma, Menno D. Stellingwerff, Truus E.M. Abbink, Marianna Bugiani, Marjo S. van der Knaap   +7 more
wiley   +1 more source

Hypomyelinating leukodystrophy-associated mutation of RARS leads it to the lysosome, inhibiting oligodendroglial morphological differentiation

Biochemistry and Biophysics Reports, 2019
Pelizaeus-Merzbacher disease (PMD) is a central nervous system (CNS) demyelinating disease in human, currently known as prototypic hypomyelinating leukodystrophy 1 (HLD1).
Naoto Matsumoto, Natsumi Watanabe, Noriko Iibe, Yuriko Tatsumi, Kohei Hattori, Yu Takeuchi, Hiroaki Oizumi, Katsuya Ohbuchi, Tomohiro Torii, Yuki Miyamoto, Junji Yamauchi   +10 more
doaj   +1 more source

Immune-mediated genesis of multiple sclerosis

Journal of Translational Autoimmunity, 2020
Multiple sclerosis (MS) is widely acknowledged to be an autoimmune disease affecting the neuronal myelin structure of the CNS. Autoantigens recognized as the target of this autoimmune process are: myelin basal protein, anti-proteolipid protein ...
Salvatore Cavallo, MD, Specialist in Medical Genetics
doaj   +1 more source

381 The role of leucine-rich PPR motif-containing protein (LRPPRC) in myelin lipid metabolism

Journal of Clinical and Translational Science, 2023
OBJECTIVES/GOALS: Leigh Syndrome, French Canadian-Type (LSFC) is a neurometabolic disorder caused by mutation of mitochondria-related gene, LRPPRC. White matter lesions and demyelination in central nervous system are common in LSFC. LRPPRC is enriched in
Bridgitte Palacios, Jiangong Ren, Jian Hu   +2 more
doaj   +1 more source

Immunology of multiple sclerosis [PDF]

, 2007
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) leading to demyelination, axonal damage, and progressive neurologic disability.
A. Ascherio, A. Kutzelnigg, A. Kutzelnigg, B. Serafini, B.T. Sadatipour, C. Confavreux, C. Lucchinetti, C.F. Lucchinetti, C.H. Polman, C.S. Raine, D. Pohl, D. Zhou, E.L. Thacker, J. Correale, J.A. James, J.M. Greer, J.M. Greer, J.M. Greer, J.R. Berger, J.R. Oksenberg, Judith M. Greer, K.P. Wandinger, L.F. Barcellos, L.F. Barcellos, L.I. Levin, L.M. Villar, L.M. Villar, M. Sospedra, M.C. Diamond, M.P. Armengol, M.P. Pender, M.P. Pender, M.P. Pender, M.P. Pender, M.P. Pender, M.P. Pender, M.P. Pender, M.P. Pender, M.S. Freedman, Michael P. Pender, P.A. McCombe, R. Gold, R.A. Williamson, R.C. Collard, R.D. Henderson, S. Cepok, S. Cepok, S. Marconi, V.A. Lennon, W. Brück, W.B. Bias, Y. Qin, Z. Tabi   +52 more
core   +1 more source

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source