Results 111 to 120 of about 13,038 (207)

Repurposing of Chemokine Antagonists for Combined Phase‐Resolved Spinal Cord Injury Treatment

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Spinal cord injury (SCI) in mammals is accompanied by a massive cytokine storm in cerebrospinal fluid, mainly driven by CXCL1, IL‐6, and CCL2‐5. Sub‐acute phase is mostly associated with IL‐2, IL‐7, CCL22, and CX3CL1, whereas TNFα and IL17α permanently persists in CNS even weeks following SCI.
Alexey A. Belogurov Jr., Georgii B. Telegin, Aleksandr S. Chernov, Anna A. Kudriaeva, Alexey N. Minakov, Maksim V. Rodionov, Vitaly A. Kazakov, Viktor A. Palikov, Yuri M. Poluektov, Rustam H. Ziganshin, Daria A. Orlova, Alena S. Evpak, Daniil A. Barsuk, Fedor A. Mesheryakov, Aldo Spallone, Dmitry S. Asyutin, Igor N. Pronin, Nikolay A. Konovalov, Dmitri Yu Usachev, Alexander G. Gabibov, Alexander N. Konovalov   +20 more
wiley   +1 more source

Human leukocyte antigen (HLA)-DRB1*15:01 and HLA-DRB5*01:01 present complementary peptide repertoires [PDF]

, 2017
Human leukocyte antigen (HLA)-DR15 is a haplotype associated with multiple sclerosis. It contains the two DRB* genes DRB1*1501 (DR2b) and DRB5*0101 (DR2a).
Alvarez, Alvarez, Andreatta, Bontrop, Busch, Collado, Consogno, Contreras, Elias, Espinosa, Gourraud, Guttinger, Kobayashi, Lang, Li, Li, Lopez de Castro, Marcilla, Mohme, Muixi, Muixi, O’Sullivan, O’Sullivan, Prat, Rammensee, Ranasinghe, Rebai, Roche, Sawcer, Scally, Scholz, Sinigaglia, Smith, Sospedra, Southwood, Vizcaino, Vogt, Wang, Wen, Wucherpfennig   +39 more
core   +2 more sources

Comprehensive profiling of Aβ40 and Aβ42 fibril‐interacting proteins reveals PRKCG as a drug‐targetable regulator of amyloidogenesis in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION Proteins interacting with amyloid beta (Aβ) fibrils could be key to plaque formation in Alzheimer's disease (AD) and represent potential biomarkers and therapeutic targets. Previous proteomic studies using microdissected plaques might have captured non‐specific components rather than true Aβ interactors.
Ana Montero‐Calle, Raquel Coronel, Juliana Manosalva, Diego Megías, Vivian de los Ríos, Alberto Rábano, Alberto Peláez‐García, Javier Martínez‐Useros, María Jesús Fernández‐Aceñero, Isabel Liste, Rodrigo Barderas   +10 more
wiley   +1 more source

Membrane-enriched proteome changes and prion protein expression during neural differentiation and in neuroblastoma cells

BMC Genomics, 2017
Background The function of the prion protein, involved in the so-called prion diseases, remains a subject of intense debate and the possibility that it works as a pleiotropic protein through the interaction with multiple membrane proteins is somehow ...
J. A. Macedo, D. Schrama, I. Duarte, E. Tavares, J. Renaut, M. E. Futschik, P. M. Rodrigues, E. P. Melo   +7 more
doaj   +1 more source

Proteomic prediction of myelin water fraction using the SomaScan 7k platform

Alzheimer's & Dementia
AbstractBackgroundMyelin loss occurs as part of neurodegenerative and neuroinflammatory conditions. Myelin water fraction (MWF), a surrogate of myelin content, can be estimated using multicomponent relaxometry MRI. In this study we investigate the relationship between 7289 plasma proteins and MWF to derive a protein‐based indicator of myelin content ...
Joynes, Cassandra M, Resnick, Susan M., Bouhrara, Mustapha, Walker, Keenan A.   +3 more
openaire   +1 more source

Mechanistic Insights of Gamma Sensory Stimulation: CSF Proteomic Analyses Reveal Changes in Myelin and Synaptic Proteins [PDF]

Alzheimers Dement
AbstractBackgroundPreclinical investigations in Alzheimer’s disease (AD) have highlighted the efficacy of gamma sensory stimulation in mitigating AD‐related pathologies. Cognito Therapeutics, Inc. (Cambridge, MA) has designed the Sensory Stimulation System for safe at‐home usage, to induce EEG‐confirmed gamma oscillations as a potential treatment for ...
Shpokayte M, Pandey K, Singer A, Doung D, Lah J, Levey A, Seyfried N, Malchano Z, Kern R, Hajos M.   +9 more
europepmc   +2 more sources

Oligodendroglial Process Formation is Differentially Affected by Modulating the Intra- and Extracellular Cholesterol Content [PDF]

, 2012
Cholesterol is an essential component of eukaryotic plasma membranes and plays an important role in membrane organization and signaling processes. It is the major lipid component of detergent resistant caveolin-1 containing rafts which previously had ...
Hans H. Althaus, Inga Zerr, Matthias Schmitz, Sandra C. Signore   +3 more
core   +1 more source

Modulation of microtubule acetylation by the interplay of TPPP/p25, SIRT2 and new anticancer agents with anti-SIRT2 potency [PDF]

, 2017
The microtubule network exerts multifarious functions controlled by its decoration with various proteins and post-translational modifications. The disordered microtubule associated Tubulin Polymerization Promoting Protein (TPPP/p25) and the NAD ...
Adél Szabó, Attila Lehotzky, Judit Oláh, Judit Ovádi, Manfred Jung, Marianna Csaplár, Matthias Schiedel, Péter Lőw, Sándor Szunyogh, Tibor Szénási   +9 more
core   +2 more sources

Comparative proteomics of the Mycobacterium leprae binding protein myelin P0: its implication in leprosy and other neurodegenerative diseases

Infection, Genetics and Evolution, 2004
Mycobacterium leprae, the causative agent of leprosy invades Schwann cells of the peripheral nerves leading to nerve damage and disfigurement, which is the hallmark of the disease. Wet experiments have shown that M. leprae binds to a major peripheral nerve protein, the myelin P zero (P0).
Deena, Vardhini, Sujai, Suneetha, Niyaz, Ahmed, D S M, Joshi, S, Karuna, X, Magee, D S R, Vijayalakshmi, V, Sridhar, K V, Karunakar, Juan J, Archelos, Lavanya M, Suneetha   +10 more
openaire   +2 more sources

Target Proteins in the Dorsal Hippocampal Formation Sustain the Memory-Enhancing and Neuroprotective Effects of Ginkgo biloba

Frontiers in Pharmacology, 2019
We have previously shown that standardized extracts of Ginkgo biloba (EGb) modulate fear memory formation, which is associated with CREB-1 (mRNA and protein) upregulation in the dorsal hippocampal formation (dHF), in a dose-dependent manner.
Renan Barretta Gaiardo, Thiago Ferreira Abreu, Alexandre Keiji Tashima, Monica Marques Telles, Suzete Maria Cerutti   +4 more
doaj   +1 more source