Results 1 to 10 of about 48,712 (325)

Oligodendrocyte calcium signaling promotes actin-dependent myelin sheath extension [PDF]

Nature Communications
Myelin is essential for rapid nerve signaling and is increasingly found to play important roles in learning and in diverse diseases of the CNS. Morphological parameters of myelin such as sheath length are thought to precisely tune conduction velocity ...
Manasi Iyer, Husniye Kantarci, Madeline H. Cooper, Nicholas Ambiel, Sammy Weiser Novak, Leonardo R. Andrade, Mable Lam, Graham Jones, Alexandra E. Münch, Xinzhu Yu, Baljit S. Khakh, Uri Manor, J. Bradley Zuchero   +12 more
doaj   +4 more sources

Myelinating Schwann Cell Polarity and Mechanically-Driven Myelin Sheath Elongation [PDF]

Frontiers in Cellular Neuroscience, 2018
Myelin sheath geometry, encompassing myelin sheath thickness relative to internodal length, is critical to optimize nerve conduction velocity and these parameters are carefully adjusted by the myelinating cells in mammals.
Nicolas Tricaud
doaj   +6 more sources

Pain kept under wraps of myelin sheath. [PDF]

Front Pain Res (Lausanne)
The myelin sheath serves both as insulator and metabolic powerhouse for large-diameter dorsal root ganglia (DRG) neurons—some of the longest cells in the body—transmitting sensory impulses from the periphery to the spinal cord. When myelin is damaged, bioactive fragments of myelin basic protein (MBP) are released, playing a pivotal role in pathological
Shubayev VI.
europepmc   +5 more sources

Myelin sheath injury and repairment after subarachnoid hemorrhage [PDF]

Frontiers in Pharmacology, 2023
Subarachnoid hemorrhage (SAH) can lead to damage to the myelin sheath in white matter. Through classification and analysis of relevant research results, the discussion in this paper provides a deeper understanding of the spatiotemporal change ...
Mao Chen, Peiwen Guo, Peiwen Guo, Peiwen Guo, Xufang Ru, Xufang Ru, Xufang Ru, Yujie Chen, Yujie Chen, Yujie Chen, Shilun Zuo, Shilun Zuo, Shilun Zuo, Shilun Zuo, Hua Feng, Hua Feng, Hua Feng   +16 more
doaj   +2 more sources

Neurokeratin Network of Myelin Sheaths [PDF]

Nature, 1960
THE recent communication of Tewari and Bourne1 on the neurokeratin network of peripheral nerve fibres is valuable not only for its intrinsic content but also because it validates the histological procedures, findings and arguments derived therefrom, by which it was concluded that neurokeratin formations are part of the architecture of the nerve fibres ...
M. A. MacConaill, EDWARD GURR
openalex   +3 more sources

Identification of 3' UTR motifs required for mRNA localization to myelin sheaths in vivo.

PLoS Biology, 2021
Myelin is a specialized membrane produced by oligodendrocytes that insulates and supports axons. Oligodendrocytes extend numerous cellular processes, as projections of the plasma membrane, and simultaneously wrap multiple layers of myelin membrane around
Katie M Yergert, Caleb A Doll, Rebecca O'Rouke, Jacob H Hines, Bruce Appel   +4 more
doaj   +3 more sources

Dynamic properties of a reconstituted myelin sheath [PDF]

Spectroscopy, 2010
Myelin is a multilamellar membrane which, wrapping the nerve axons, increases the efficiency of nervous signal transmission. Indeed, the molecular components of the myelin sheath interact tightly with each other and molecules on the axonal surface to drive myelination, to keep both myelin and the axon intact, and to transduce signals from myelin to the
W. Knoll, Francesca Natali, Judith Peters, Rahul Nanekar, C. Wang, Petri Kursula   +5 more
openalex   +6 more sources

Clinical concentration of sevoflurane had no short-term effect on the myelin sheath in prefrontal cortex of aged marmosets [PDF]

Frontiers in Neuroscience
IntroductionThe fragile brain includes both the developing brain in childhood and the deteriorating brain in elderly. While the effects of general anesthesia on the myelin sheath of developing brain have been well-documented, limited research has ...
Zhengjie Miao, Yi Jiang, Fangfang Wang, Lingling Shi, Ren Zhou, Yixuan Niu, Lei Zhang   +6 more
doaj   +2 more sources

A Nanoscale Model System for the Human Myelin Sheath [PDF]

Biomacromolecules, 2021
Here, we for the first time establish nanodiscs with the challenging lipid composition of myelin of the peripheral or central nervous systems, respectively (PNS and CNS, both containing >40% cholesterol, which so far has been thought to be detrimental for nanodisc formation).Thus, we prove that more complex lipid model membrane systems are in ...
Matthias C. Hoffmann, David Haselberger, Tommy Hofmann, Lisa Müller, Kevin D. Janson, Annette Meister, Manabendra Das, Carolyn Vargas, Sandro Keller, Panagiotis L. Kastritis, Carla Schmidt, Dariush Hinderberger   +11 more
openalex   +5 more sources

Treadmilling Model for Plasticity of the Myelin Sheath. [PDF]

Trends Neurosci, 2019
We propose a mechanism for myelin plasticity that would complement synaptic plasticity by adjusting conduction velocity for optimal spike-time arrival. In the proposed treadmilling model, myelin sheath thickness is a dynamic balance between the rates of new myelin deposited adjacent to the axon and removal of the outermost layer.
Fields RD, Dutta DJ.
europepmc   +5 more sources