Myelinating Schwann Cell Polarity and Mechanically-Driven Myelin Sheath Elongation [PDF]
Frontiers in Cellular Neuroscience, 2018 Myelin sheath geometry, encompassing myelin sheath thickness relative to internodal length, is critical to optimize nerve conduction velocity and these parameters are carefully adjusted by the myelinating cells in mammals.
Nicolas Tricaud
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Myelin sheath injury and repairment after subarachnoid hemorrhage [PDF]
Frontiers in Pharmacology, 2023 Subarachnoid hemorrhage (SAH) can lead to damage to the myelin sheath in white matter. Through classification and analysis of relevant research results, the discussion in this paper provides a deeper understanding of the spatiotemporal change ...
Mao Chen +16 more
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Oligodendrocyte HCN2 Channels Regulate Myelin Sheath Length. [PDF]
J Neurosci, 2021 Oligodendrocytes generate myelin sheaths vital for the formation, health, and function of the CNS. Myelin sheath length is a key property that determines axonal conduction velocity and is known to be variable across the CNS. Myelin sheath length can be modified by neuronal activity, suggesting that dynamic regulation of sheath length might contribute ...
Swire M +5 more
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Clinical concentration of sevoflurane had no short-term effect on the myelin sheath in prefrontal cortex of aged marmosets [PDF]
Frontiers in NeuroscienceIntroductionThe fragile brain includes both the developing brain in childhood and the deteriorating brain in elderly. While the effects of general anesthesia on the myelin sheath of developing brain have been well-documented, limited research has ...
Zhengjie Miao +6 more
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Oligodendrocyte calcium signaling promotes actin-dependent myelin sheath extension [PDF]
Nature CommunicationsMyelin is essential for rapid nerve signaling and is increasingly found to play important roles in learning and in diverse diseases of the CNS. Morphological parameters of myelin such as sheath length are thought to precisely tune conduction velocity ...
Manasi Iyer +12 more
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Post-synaptic density proteins in oligodendrocytes are required for activity-dependent myelin sheath growth [PDF]
iScienceSummary: Neuronal activity regulates myelination in the central nervous system, highlighting the critical importance of axon-oligodendrocyte communications in myelin physiology and function.
Mary-Amélie Masson +3 more
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A myelin sheath protein forming its lattice. [PDF]
J Biol Chem, 2020 The formation of a mature, multilayered myelin sheath requires the compaction of lipid bilayers, but the molecular mechanism by which these bilayers condense is an open question. In this issue, Ruskamo et al. find that peripheral myelin protein P2 forms an ordered three-dimensional lattice within model membranes using Escherichia coli polar lipid ...
Tsuge H.
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Pain kept under wraps of myelin sheath. [PDF]
Front Pain Res (Lausanne)The myelin sheath serves both as insulator and metabolic powerhouse for large-diameter dorsal root ganglia (DRG) neurons—some of the longest cells in the body—transmitting sensory impulses from the periphery to the spinal cord. When myelin is damaged, bioactive fragments of myelin basic protein (MBP) are released, playing a pivotal role in pathological
Shubayev VI.
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Shielding effects of myelin sheath on axolemma depolarization under transverse electric field stimulation [PDF]
PeerJ, 2018 Axonal stimulation with electric currents is an effective method for controlling neural activity. An electric field parallel to the axon is widely accepted as the predominant component in the activation of an axon.
Hui Ye, Jeffrey Ng
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Role of Connexin-Based Gap Junction Channels in Communication of Myelin Sheath in Schwann Cells [PDF]
Frontiers in Cellular Neuroscience, 2019 Peripheral nerves have the capacity to conduct action potentials along great distances and quickly recover following damage which is mainly due to Schwann cells (SCs), the most abundant glial cells of the peripheral nervous system (PNS).
Bruno A. Cisterna +3 more
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