Myelinating Schwann Cell Polarity and Mechanically-Driven Myelin Sheath Elongation [PDF]
Frontiers in Cellular Neuroscience, 2018 Myelin sheath geometry, encompassing myelin sheath thickness relative to internodal length, is critical to optimize nerve conduction velocity and these parameters are carefully adjusted by the myelinating cells in mammals.
Nicolas Tricaud
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Oligodendrocyte HCN2 Channels Regulate Myelin Sheath Length. [PDF]
J Neurosci, 2021 Oligodendrocytes generate myelin sheaths vital for the formation, health, and function of the CNS. Myelin sheath length is a key property that determines axonal conduction velocity and is known to be variable across the CNS. Myelin sheath length can be modified by neuronal activity, suggesting that dynamic regulation of sheath length might contribute ...
Swire M +5 more
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Oligodendrocyte calcium signaling promotes actin-dependent myelin sheath extension [PDF]
Nature CommunicationsMyelin is essential for rapid nerve signaling and is increasingly found to play important roles in learning and in diverse diseases of the CNS. Morphological parameters of myelin such as sheath length are thought to precisely tune conduction velocity ...
Manasi Iyer +12 more
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Post-synaptic density proteins in oligodendrocytes are required for activity-dependent myelin sheath growth [PDF]
iScienceSummary: Neuronal activity regulates myelination in the central nervous system, highlighting the critical importance of axon-oligodendrocyte communications in myelin physiology and function.
Mary-Amélie Masson +3 more
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Microglia phagocytose myelin sheaths to modify developmental myelination [PDF]
Nature Neuroscience, 2020 During development, oligodendrocytes contact and wrap neuronal axons with myelin. Similarly to neurons and synapses, excess myelin sheaths are produced and selectively eliminated, but how elimination occurs is unknown. Microglia, the resident immune cells of the central nervous system, engulf surplus neurons and synapses. To determine whether microglia
Alexandria N Hughes, Bruce Appel
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Shielding effects of myelin sheath on axolemma depolarization under transverse electric field stimulation [PDF]
PeerJ, 2018 Axonal stimulation with electric currents is an effective method for controlling neural activity. An electric field parallel to the axon is widely accepted as the predominant component in the activation of an axon.
Hui Ye, Jeffrey Ng
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Myelin sheath injury and repairment after subarachnoid hemorrhage [PDF]
Frontiers in Pharmacology, 2023 Subarachnoid hemorrhage (SAH) can lead to damage to the myelin sheath in white matter. Through classification and analysis of relevant research results, the discussion in this paper provides a deeper understanding of the spatiotemporal change ...
Mao Chen +16 more
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Clinical concentration of sevoflurane had no short-term effect on the myelin sheath in prefrontal cortex of aged marmosets [PDF]
Frontiers in NeuroscienceIntroductionThe fragile brain includes both the developing brain in childhood and the deteriorating brain in elderly. While the effects of general anesthesia on the myelin sheath of developing brain have been well-documented, limited research has ...
Zhengjie Miao +6 more
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Image Analysis and Stereology, 2017 Studies have provided qualitative evidence of de-myelination and re-myelination in aged brain white matter. However, there have been no quantitative evidences of degeneration and regeneration of myelin sheaths in white matter.
Chen Li +4 more
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A diffusion MRI model for random walks confined on cylindrical surfaces: towards non-invasive quantification of myelin sheath radius [PDF]
Frontiers in PhysicsIntroductionQuantifying the myelin sheath radius of myelinated axons in vivo is important for understanding, diagnosing, and monitoring various neurological disorders.
Erick J. Canales-Rodríguez +13 more
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