Results 111 to 120 of about 201,896 (346)
eLife, 2019 Myelin serves as an axonal insulator that facilitates rapid nerve conduction along axons. By transmission electron microscopy, a healthy myelin sheath comprises compacted membrane layers spiraling around the cross-sectioned axon. Previously we identified
Michelle S Erwig +11 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.Quercetin regulates signaling pathways in neurodegenerative diseases, including NF‐κB, sirtuins, and PI3K/Akt. Studies show quercetin improves symptoms and pathology in neurodegenerative models. The study aims to incorporate laboratory research into practical medical treatment, focusing on quercetin's neuroprotective effects and optimal dosage ...
Md. Rezaul Islam +13 more
wiley +1 more source
European Journal of Neuroscience, Volume 56, Issue 12, Page 6099-6114, December 2022., 2022 Using environmental enrichment to physiologically induce neuroplasticity in the young adult mouse, we find dynamic structural remodelling of axons and their pre‐existing myelin sheaths. Additionally, we find that oligodendrocytes respond primarily with an increase in differentiation and regionally specific decreases in progenitor density. These results
Madeline Nicholson +6 more
wiley +1 more source
Natural electromagnetic waveguide structures based on myelin sheath in the neural system [PDF]
arXiv, 2012 The saltatory propagation of action potentials on myelinated axons is conventionally explained by the mechanism employing local circuit ionic current flows between nodes of Ranvier. Under this framework, the myelin sheath with up to 100 layers of membrane only serves as the insulating shell.
arxiv
Fibroblast Growth Factor Receptor Signaling in Oligodendrocytes Regulates Myelin Sheath Thickness
Journal of Neuroscience, 2012 Formation of the CNS white matter is developmentally tightly regulated, but the molecules and mechanisms of myelination control in the postnatal CNS are poorly understood.
M. Furusho +3 more
semanticscholar +1 more source
Animal Models and Experimental Medicine, EarlyView.Unilateral, minimally invasive, renal arterial embolization and delayed contralateral nephrectomy was described in cats as a novel remnant kidney model of chronic kidney disease using two doses of embolic particles. Renal function declined and characteristic histopathological markers of kidney disease were present 6 months after the embolism procedure.
Chad W. Schmiedt +7 more
wiley +1 more source
European Journal of Neurology, Volume 30, Issue 2, Page 511-526, February 2023., 2023 Abstract Background and purpose Charcot–Marie–Tooth disease (CMT) is a heterogeneous group of disorders caused by mutations in at least 100 genes. However, approximately 60% of cases with axonal neuropathies (CMT2) still remain without a genetic diagnosis. We aimed at identifying novel disease genes responsible for CMT2.
Silvia Cipriani +23 more
wiley +1 more source
Myelin membrane assembly is driven by a phase transition of myelin basic proteins into a cohesive protein meshwork. [PDF]
PLoS Biology, 2013 Rapid conduction of nerve impulses requires coating of axons by myelin. To function as an electrical insulator, myelin is generated as a tightly packed, lipid-rich multilayered membrane sheath.
Shweta Aggarwal +11 more
doaj +1 more source
Science Translational Medicine, 2012 Myelin fatty acids resolve neuroinflammation. Eliminating Excess In tough economic times, businesses trim the fat by cutting superfluous spending. The immune system also has ways to regulate excess, such as feedback mechanisms that prevent autoimmunity ...
P. Ho +20 more
semanticscholar +1 more source
Astrocytes and Microglia as Major Players of Myelin Production in Normal and Pathological Conditions
Frontiers in Cellular Neuroscience, 2020 Myelination is an essential process that consists of the ensheathment of axons by myelin. In the central nervous system (CNS), myelin is synthesized by oligodendrocytes. The proliferation, migration, and differentiation of oligodendrocyte precursor cells
E. Traiffort +3 more
semanticscholar +1 more source