Results 111 to 120 of about 232,901 (341)
Nanoscale correlated disorder in out-of-equilibrium myelin ultrastructure
, 2017 Ultrastructural fluctuations at nanoscale are fundamental to assess properties and functionalities of advanced out-of-equilibrium materials. We have taken myelin as a model of supramolecular assembly in out-of-equilibrium living matter.
Bianconi, Antonio +6 more
core +1 more source
Restoration of SMN in Schwann cells reverses myelination defects and improves neuromuscular function in spinal muscular atrophy [PDF]
, 2016 Spinal muscular atrophy (SMA) is a neuromuscular disease caused by low levels of SMN protein, primarily affecting lower motor neurons. Recent evidence from SMA and related conditions suggests that glial cells can influence disease severity.
Brophy, Peter J. +9 more
core +3 more sources
Advanced Science, EarlyView.Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Junqiu Jia +13 more
wiley +1 more source
Are there optical communication channels in the brain?
, 2017 Despite great progress in neuroscience, there are still fundamental unanswered questions about the brain, including the origin of subjective experience and consciousness. Some answers might rely on new physical mechanisms. Given that biophotons have been
Barclay, Paul +4 more
core +1 more source
Optimization of electron microscopy for human brains with long-term fixation and fixed-frozen sections. [PDF]
, 2014 BackgroundAbnormal connectivity across brain regions underlies many neurological disorders including multiple sclerosis, schizophrenia and autism, possibly due to atypical axonal organization within white matter.
Liu, Xiao-Bo, Schumann, Cynthia M
core +1 more source
Myelin organization in the nodal, paranodal, and juxtaparanodal regions revealed by scanning x-ray microdiffraction. [PDF]
PLoS ONE, 2014 X-ray diffraction has provided extensive information about the arrangement of lipids and proteins in multilamellar myelin. This information has been limited to the abundant inter-nodal regions of the sheath because these regions dominate the scattering ...
Hideyo Inouye +6 more
doaj +1 more source
Advanced Science, EarlyView.This study reveals that Schwann cell FDFT1‐mediated cholesterol synthesis is essential for peripheral nerve regeneration via dual roles: as a structural component for myelin and as a metabolic signal that upregulates IGF1. IGF1 promotes axonal growth through paracrine action and enhances Schwann cell differentiation/ myelination via an intrinsic IGF1R ...
Shuyi Xu +12 more
wiley +1 more source
A Jones matrix formalism for simulating three-dimensional polarized light imaging of brain tissue [PDF]
, 2015 The neuroimaging technique three-dimensional polarized light imaging (3D-PLI) provides a high-resolution reconstruction of nerve fibres in human post-mortem brains.
Amunts, Katrin +5 more
core +4 more sources
eLife, 2019 Myelin serves as an axonal insulator that facilitates rapid nerve conduction along axons. By transmission electron microscopy, a healthy myelin sheath comprises compacted membrane layers spiraling around the cross-sectioned axon. Previously we identified
Michelle S Erwig +11 more
doaj +1 more source
Advanced Intelligent Systems, EarlyView.Leveraging spinning‐induced localized suction, the spinner device enables ultra‐efficient removal of kidney stone fragments, capturing a larger quantity of fragments from distances exceeding 20 mm. The spinner significantly improves the efficiency and effectiveness of stone fragment removal by reducing operative time, increasing stone‐free rates, and ...
Yilong Chang +3 more
wiley +1 more source