Results 141 to 150 of about 201,896 (346)

The signal synchronization function of myelin [PDF]

arXiv
The myelinated axons are widely present in both central and peripheral nervous systems. Its unique compact spiraling structure poses significant challenges to understanding its biological functions and developmental mechanisms. Conventionally, myelin is considered as an insulating layer to achieve saltatory conduction for the enhancement of the neural ...
arxiv  

Pals1 Is a Major Regulator of the Epithelial-Like Polarization and the Extension of the Myelin Sheath in Peripheral Nerves

Journal of Neuroscience, 2010
Diameter, organization, and length of the myelin sheath are important determinants of the nerve conduction velocity, but the basic molecular mechanisms that control these parameters are only partially understood. Cell polarization is an essential feature
Murat Özçelik, L. Cotter, C. Jacob, J. Pereira, J. Relvas, U. Suter, N. Tricaud   +6 more
semanticscholar   +1 more source

Interpretation of inhomogeneous magnetization transfer in myelin water using a four‐pool model with dipolar reservoirs

Magnetic Resonance in Medicine, EarlyView.
Abstract Purpose To confirm ihMT's specificity to myelin, an ihMT presaturation module was combined with a Poon–Henkelman multi‐echo spin‐echo readout to separate the ihMT signal in myelin water from intra‐/extra‐cellular water. This study explored the relationship between two quantitative myelin imaging techniques and measured the ihMT signal of ...
Michelle H. Lam, Masha Novoselova, Andrew Yung, Valentin H. Prevost, Alan P. Manning, Jie Liu, Wolfram Tetzlaff, Piotr Kozlowski   +7 more
wiley   +1 more source

The intrinsic fluorescence of isolated central-nervous-system myelin-sheath preparations [PDF]

, 1979
A. J. Crang, Martin G. Rumsby
openalex   +1 more source

Modified FGF Hydrogel for Effective Axon Formation by Enhanced Regeneration of Myelin Sheath of Schwann Cells Using Rat Model. [PDF]

Int J Nanomedicine, 2023
Li J, Shangguan Z, Ye X, Wang Z, Liu W, Chen G.   +5 more
europepmc   +1 more source

Sex‐specific white matter alterations in children exposed to high pregestational BMI

Obesity, EarlyView.
Abstract Objective This study investigated whether exposure to high pregestational BMI (≥ 25 kg/m2) is associated with alterations in white matter microstructure in early childhood, explored sex‐specific effects, and examined associations with cognitive performance. Methods A total of 90 children from the Alberta Pregnancy Outcomes and Nutrition (APrON)
Samson Nivins, Jess Reynolds, Gerald F. Giesbrecht, Deborah Dewey, Nicole Letourneau, Catherine Lebel   +5 more
wiley   +1 more source

The transcription factor Stat-1 is essential for Schwann cell differentiation, myelination and myelin sheath regeneration. [PDF]

Mol Med, 2023
Xu J, Zhang B, Cai J, Peng Q, Hu J, Askar P, Shangguan J, Su W, Zhu C, Sun H, Zhou S, Chen G, Yang X, Gu Y.   +13 more
europepmc   +1 more source

The modelling of the action potentials in myelinated nerve fibres [PDF]

arXiv
The classical Hodgkin-Huxley model describes the propagation of an axon potential (AP) in unmyelinated axons. In many cases the axons have a myelin sheath and the experimental studies have then revealed significant changes in the velocity of APs. In this paper, a theoretical model is proposed describing the AP propagation in myelinated axons. As far as
arxiv  

Docosahexaenoic acid ameliorates autistic‐like behaviors by inhibiting oxidative stress and inflammatory response in neonatal maternal separation rats

Pediatric Discovery, EarlyView.
The JNK pathway and oxidative stress are activated, and pro‐inflammatory cytokines are increased in neonatal maternal separation (NMS) rats. While docosahexaenoic acid treatment suppresses the activation of JNK pathway and oxidative stress, and reduces pro‐inflammatory cytokines release, thereby improving autism‐like behavior induced by NMS.
Boqing Xu, Hao Yuan, Xiaohuan Li, Qingyang Yu, Chunfang Dai, Zhifang Dong   +5 more
wiley   +1 more source

Role of fenofibrate in multiple sclerosis

European Journal of Medical Research
Multiple sclerosis (MS) is the most frequent inflammatory and demyelinating disease of the central nervous system (CNS). The underlying pathophysiology of MS is the destruction of myelin sheath by immune cells.
Ahmad A. Abulaban, Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Engy Elekhnawy, Asma Alanazi, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batiha   +7 more
doaj   +1 more source