Peripheral Nerve Diffusion Tensor Imaging: Assessment of Axon and Myelin Sheath Integrity. [PDF]
PLoS ONE, 2015 To investigate the potential of diffusion tensor imaging (DTI) parameters as in-vivo biomarkers of axon and myelin sheath integrity of the median nerve in the carpal tunnel as validated by correlation with electrophysiology.MRI examinations at 3T ...
A Heckel +7 more
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A myelin sheath protein forming its lattice. [PDF]
J Biol Chem, 2020 The formation of a mature, multilayered myelin sheath requires the compaction of lipid bilayers, but the molecular mechanism by which these bilayers condense is an open question. In this issue, Ruskamo et al. find that peripheral myelin protein P2 forms an ordered three-dimensional lattice within model membranes using Escherichia coli polar lipid ...
Tsuge H.
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Entangled biphoton generation in the myelin sheath
Physical Review EConsciousness within the brain hinges on the synchronized activities of millions of neurons, but the mechanism responsible for orchestrating such synchronization remains elusive. In this study, we employ cavity quantum electrodynamics (cQED) to explore entangled biphoton generation through cascade emission in the vibration spectrum of C-H bonds within ...
Zefei Liu, Yong-Cong Chen, Ping Ao
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Pain kept under wraps of myelin sheath. [PDF]
Front Pain Res (Lausanne)The myelin sheath serves both as insulator and metabolic powerhouse for large-diameter dorsal root ganglia (DRG) neurons—some of the longest cells in the body—transmitting sensory impulses from the periphery to the spinal cord. When myelin is damaged, bioactive fragments of myelin basic protein (MBP) are released, playing a pivotal role in pathological
Shubayev VI.
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Evidence for Myelin Sheath Remodeling in the CNS Revealed by In Vivo Imaging [PDF]
Current Biology, 2018 Franziska Auer +2 more
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Brain region‐specific amyloid plaque‐associated myelin lipid loss, APOE deposition and disruption of the myelin sheath in familial Alzheimer’s disease mice [PDF]
Journal of Neurochemistry, 2020 There is emerging evidence that amyloid beta (Aβ) aggregates forming neuritic plaques lead to impairment of the lipid‐rich myelin sheath and glia.
Ibrahim Kaya +5 more
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Role of Connexin-Based Gap Junction Channels in Communication of Myelin Sheath in Schwann Cells [PDF]
Frontiers in Cellular Neuroscience, 2019 Peripheral nerves have the capacity to conduct action potentials along great distances and quickly recover following damage which is mainly due to Schwann cells (SCs), the most abundant glial cells of the peripheral nervous system (PNS).
Bruno A. Cisterna +3 more
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The Akt-mTOR Pathway Drives Myelin Sheath Growth by Regulating Cap-Dependent Translation. [PDF]
J Neurosci, 2021 In the vertebrate CNS, oligodendrocytes produce myelin, a specialized membrane, to insulate and support axons. Individual oligodendrocytes wrap multiple axons with myelin sheaths of variable lengths and thicknesses.
Fedder-Semmes KN, Appel B.
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Axonal Neuregulin-1 Regulates Myelin Sheath Thickness
Science, 2004 In the nervous system of vertebrates, myelination is essential for rapid and accurate impulse conduction. Myelin thickness depends on axon fiber size. We use mutant and transgenic mouse lines to show that axonal Neuregulin-1 (Nrg1) signals information about axon size to Schwann cells.
Michailov, G. +9 more
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[The damaging effects of two exposures to 100 dB white noise on myelination of the auditory nerve in mouse cochleae mechanism of repeated noise exposure on myelin sheath of cochlear auditory nerve in mice]. [PDF]
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za ZhiZhang S, Liu K, Gong S.
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