Results 21 to 30 of about 108,757 (334)
MicroRNA-23a promotes myelination in the central nervous system. [PDF]
, 2013 Demyelinating disorders including leukodystrophies are devastating conditions that are still in need of better understanding, and both oligodendrocyte differentiation and myelin synthesis pathways are potential avenues for developing treatment ...
Fu, Ying-Hui +5 more
core +2 more sources
Neurotherapeutics, 2021 Myelin is a key evolutionary specialization and adaptation of vertebrates formed by the plasma membrane of glial cells, which insulate axons in the nervous system. Myelination not only allows rapid and efficient transmission of electric impulses in the axon by decreasing capacitance and increasing resistance but also influences axonal metabolism and ...
openaire +3 more sources
eLife, 2019 GABAergic fast-spiking parvalbumin-positive (PV) interneurons are frequently myelinated in the cerebral cortex. However, the factors governing the topography of cortical interneuron myelination remain incompletely understood.
Jeffrey Stedehouder +10 more
doaj +1 more source
Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system
eLife, 2017 Myelination is a biosynthetically demanding process in which mTORC1, the gatekeeper of anabolism, occupies a privileged regulatory position. We have shown previously that loss of mTORC1 function in Schwann cells (SCs) hampers myelination.
Gianluca Figlia +4 more
doaj +1 more source
The development of a ε-polycaprolactone (PCL) scaffold for CNS repair [PDF]
, 2012 Potential treatment strategies for the repair of spinal cord injury (SCI) currently favour a combinatorial approach incorporating several factors, including exogenous cell transplantation and biocompatible scaffolds. The use of scaffolds for bridging the
Gelain F. +9 more
core +1 more source
Whole genome sequencing-based mapping and candidate identification of mutations from fixed zebrafish tissue [PDF]
, 2017 As forward genetic screens in zebrafish become more common, the number of mutants that cannot be identified by gross morphology or through transgenic approaches, such as many nervous system defects, has also increased.
Ackerman, Sarah D +8 more
core +3 more sources
Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes.
PLoS Biology, 2013 Myelination is essential for rapid impulse conduction in the CNS, but what determines whether an individual axon becomes myelinated remains unknown. Here we show, using a myelinating coculture system, that there are two distinct modes of myelination, one
Iben Lundgaard +11 more
doaj +1 more source
Astroglial-axonal interactions during early stages of myelination in mixed cultures using in vitro and ex vivo imaging techniques [PDF]
, 2014 <b>Background</b><p></p> Myelination is a very complex process that requires the cross talk between various neural cell types.
Anderson, Kurt I +4 more
core +2 more sources
Data supporting the role of Fyn in initiating myelination in the peripheral nervous system
Data in Brief, 2016 Transgenic mice, which express active Fyn tyrosine kinase under the control of a glial fibrillary acidic protein promoter, have been produced. This promoter induces protein expression in the initiation stage of myelination in the peripheral nervous ...
Yuki Miyamoto +7 more
doaj +1 more source
Fushe yanjiu yu fushe gongyi xuebao, 2021 A rat radiation injury model was constructed, in which myelin basic protein (MBP) expression was detected via western blot. Primary oligodendrocyte precursor cells (OPCs) and neuronal cells were isolated from Sprague-Dawley rats, and expression of ...
WANG Yanyan +5 more
doaj +1 more source