Results 31 to 40 of about 108,757 (334)
Myelin pathology: Involvement of molecular chaperones and the promise of chaperonotherapy [PDF]
, 2019 The process of axon myelination involves various proteins including molecular chaperones. Myelin alteration is a common feature in neurological diseases due to structural and functional abnormalities of one or more myelin proteins.
Cappello F. +4 more
core +1 more source
Myelin lipid metabolism and its role in myelination and myelin maintenance
The Innovation, 2023 Myelin is a specialized cell membrane indispensable for rapid nerve conduction. The high abundance of membrane lipids is one of myelin's salient features that contribute to its unique role as an insulator that electrically isolates nerve fibers across their myelinated surface.
Joseph A. Barnes-Vélez +2 more
openaire +3 more sources
Data on the effect of knockout of cytohesin-1 in myelination-related protein kinase signaling
Data in Brief, 2017 Cytohesin-1 is the guanine-nucleotide exchange factor of Arf6, a small GTPase of Arf family, and participates in cellular morphological changes. Knockout mice of cytohesin-1 exhibit decreased myelination of neuronal axons in the peripheral nervous system
Ruri Tsuneishi +11 more
doaj +1 more source
Assessment of normal myelination in infants and young children using the T1w/T2w mapping technique
Frontiers in Neuroscience, 2023 BackgroundWhite matter myelination is a crucial process of CNS maturation. The purpose of this study was to validate the T1w/T2w mapping technique for brain myelination assessment in infants and young children.MethodsNinety-four patients (0–23 months of ...
Elena Filimonova +9 more
doaj +1 more source
Klotho pathways, myelination disorders, neurodegenerative diseases, and epigenetic drugs [PDF]
, 2020 In this review we outline a rationale for identifying neuroprotectants aimed at inducing endogenous Klotho activity and expression, which is epigenetic action, by definition. Such an approach should promote remyelination and/or stimulate myelin repair by
Chen, Xiaohong +15 more
core +1 more source
Journal of Neuroscience Research, 2009 AbstractThe capacity to fold proteins properly is fundamental for cell survival. Secreted and transmembrane proteins are synthesized in the endoplasmic reticulum (ER), an organelle that has the ability to discriminate between native and nonnative proteins, in a process called protein quality control.
D'Antonio, Maurizio +2 more
openaire +2 more sources
Preliminary Evidence of Increased Hippocampal Myelin Content in Veterans with Posttraumatic Stress Disorder. [PDF]
, 2015 Recent findings suggest the formation of myelin in the central nervous system by oligodendrocytes is a continuous process that can be modified with experience.
Chao, Linda L +4 more
core +1 more source
Frontiers in Cellular Neuroscience, 2021 The benefits of transplanting cultured Schwann cells (SCs) for the treatment of spinal cord injury (SCI) have been systematically investigated in experimental animals since the early 1990s. Importantly, human SC (hSC) transplantation for SCI has advanced
Paula V. Monje +5 more
doaj +1 more source
Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination. [PDF]
, 2011 Permanent damage to white matter tracts, comprising axons and myelinating oligodendrocytes, is an important component of brain injuries of the newborn that cause cerebral palsy and cognitive disabilities, as well as multiple sclerosis in adults. However,
Baranzini, Sergio E +11 more
core +3 more sources
Nature Communications, 2020 Myelination by Schwann cells (SC) in the peripheral nervous system is essential for motor function, and dysregulation of SC myelination can lead to various neuropathies.
Jincheng Wang +9 more
doaj +1 more source