Results 41 to 50 of about 43,839 (265)

Role of IL-33 and ST2 signalling pathway in multiple sclerosis: expression by oligodendrocytes and inhibition of myelination in central nervous system [PDF]

, 2016
Recent research findings have provided convincing evidence indicating a role for Interleukin-33 (IL-33) signalling pathway in a number of central nervous system (CNS) diseases including multiple sclerosis (MS) and Alzheimer’s disease.
Allan, Debbie, Barnett, Susan C., Elliott, Christina, Fairlie-Clarke, Karen J., Jiang, Hui-Rong, Lassmann, Hans, Linnington, Christopher, Schuh, Cornelia   +7 more
core   +2 more sources

A companion to the preclinical common data elements and case report forms for in vivo rodent neuroimaging: A report of the TASK3‐WG3 Neuroimaging Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Erwin A. van Vliet, Riikka Immonen, Ofer Prager, Alon Friedman, Jens P. Bankstahl, David K. Wright, Terence J. O'Brien, Heidrun Potschka, Olli Gröhn, Neil G. Harris   +9 more
wiley   +1 more source

Development of a novel 3D culture system for screening features of a complex implantable device for CNS repair [PDF]

, 2013
Tubular scaffolds which incorporate a variety of micro- and nanotopographies have a wide application potential in tissue engineering especially for the repair of spinal cord injury (SCI).
Bereiter-Hahn J., Casey B. G., Cavaglia M., Chary S. R., Clark P., Csaderova L., Gadegaard N., Gadegaard N., Gailit J., Gilbert R. J., Huh D., Lakatos A., Mathis O. Riehle, Mirastschijski U., Nikolaj Gadegaard, Noble M., Peter S. Donoghue, Robert P., Ruff R. L., Salem A. K., Sarkar S., Seunarine K., Sun T., Sun T., Sun T., Susan C. Barnett, Sørensen A., Sørensen A., Tao Sun, Thomson C. E., Van Harreveld A., Yamada M.   +31 more
core   +3 more sources

Switching modes of myelination [PDF]

Nature Reviews Neuroscience, 2014
A new study shows that myelination may proceed in activity-dependent and -independent manners and that activity-dependent myelination is linked to neuregulin-induced signalling in oligodendrocytes, which makes these cells more sensitive to glutamate release.
openaire   +3 more sources

UDP‐glucose dehydrogenase variants cause dystroglycanopathy

Annals of Clinical and Translational Neurology, EarlyView.
Abstract UDP‐glucose dehydrogenase (UGDH) variants have been associated with hypotonia, developmental delay, and epilepsy. We report the first pathologic evidence of dystroglycanopathy in siblings with UGDH variants. Both presented around 6 months with developmental delay and elevated creatinine kinase.
Anna M. Reelfs, Carrie M. Stephan, Theresa M. Czech, Mary O. Cox, Soumya Joseph, Benjamin W. Darbro, Steven A. Moore, Kevin P. Campbell, Katherine D. Mathews   +8 more
wiley   +1 more source

Chiral Engineered Biomaterials: New Frontiers in Cellular Fate Regulation for Regenerative Medicine

Advanced Functional Materials, EarlyView.
Chiral engineered biomaterials can selectively influence cell behaviors in regenerative medicine. This review covers chiral engineered biomaterials in terms of their fabrication methods, cellular response mechanisms, and applications in directing stem cell differentiation and tissue function.
Yuwen Wang, Xin Zhang, Denghui Xie, Chunying Chen, Zhifeng Huang, Zhong Alan Li   +5 more
wiley   +1 more source

Engineering the Future of Restorative Clinical Peripheral Nerve Surgery

Advanced Healthcare Materials, EarlyView.
What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell, Zarina S. Ali, Eric L. Zager, Joseph M. Rosen, Mykhailo M. Tatarchuk, D. Kacy Cullen   +5 more
wiley   +1 more source

Changes of statistical structural fluctuations unveils an early compacted degraded stage of PNS myelin [PDF]

Scientific Reports 4, 5430 (2014), 2013
Degradation of the myelin sheath is a common pathology underlying demyelinating neurological diseases from Multiple Sclerosis to Leukodistrophies. Although large malformations of myelin ultrastructure in the advanced stages of Wallerian degradation is known, its subtle structural variations at early stages of demyelination remains poorly characterized.
arxiv   +1 more source

The spectrum of Ischemia-induced white matter injury varies with age [PDF]

, 2013
Stroke is a neurological condition that targets the whole range of the human population, from the pre-term infant to the elderly and is a major cause of death worldwide (Ingall 2004).
Muscat, Richard, Valentino, Mario, Zammit, Christian   +2 more
core   +1 more source

Myelin-Associated Glycoprotein Is a Myelin Signal that Modulates the Caliber of Myelinated Axons [PDF]

The Journal of Neuroscience, 1998
Myelination increases neuronal conduction velocity through its insulating properties and an unidentified extrinsic effect that increases axonal caliber. Although it is well established that demyelination can cause axonal atrophy, the myelin molecule that regulates axonal caliber is not known.
Chumei Li, John W. Griffin, Bruce D. Trapp, Thomas O. Crawford, Virginia M.-Y. Lee, John C. Roder, Xinghua Yin, Pang-Hsien Tu   +7 more
openaire   +3 more sources