Results 131 to 140 of about 44,768 (301)

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source

The Crosstalk between Myeloid Derived Suppressor Cells and Immune Cells: To Establish Immune Tolerance in Transplantation

Journal of Immunology Research, 2016
Myeloid derived suppressor cells (MDSCs) are a heterogeneous population of myeloid precursor and progenitor cells and endowed with a robust immunosuppressive activity in multiple pathophysiological conditions.
Chao Zhang, Shuo Wang, Cheng Yang, Ruiming Rong   +3 more
doaj   +1 more source

Regulatory lymphoid and myeloid cells determine the cardiac immunopathogenesis of Trypanosoma cruzi infection [PDF]

, 2018
Chagas disease is a multisystemic disorder caused by the protozoan parasite Trypanosoma cruzi, which affects ~8 million people in Latin America, killing 7,000 people annually.
Abrahamsohn, Aliberti, Aliberti, Anderssohn, Antúnez, Antúnez, Araujo, Argüello, Arocena, Bergeron, Bettelli, Blackwell, Bonney, Bronte, Bronte, Bronte, Brys, Böhme, Cabalén, Cabral-Piccin, Cai, Calderón, Carbajosa, Cardillo, Chen, Choi, Collison, Cuervo, Cuervo, da Costa, da Matta Guedes, de Araújo, Esper, Flores-García, Gabrilovich, Gallina, Gao, Gazzinelli, Geissmann, Ghassabeh, Gironès, Golden, Gomes, González, González, González, Goñi, Guedes, Guerrero, Guilliams, Hall, Holscher, Jäger, Kitada, Konig, Kotner, Kralova, Kumar, Lewis, Luna-Gomes, Mariano, Martin, Matos, Medina, Mengel, Ming, Miyazaki, Munder, Muñoz-Fernández, Müller, Nihei, Perez-Molina, Ponce, Poncini, Rassi, Rodriguez, Roffê, Sakaguchi, Sales, Sanmarco, Sanoja, Santamaría, Silva, Silva, Silverio, Stempin, Teerlink, Telleria, Tosello Boari, Vasconcelos, Vincendeau, Wirth, Wynn, Zingales, Zingales   +94 more
core   +3 more sources

Advances in Gastric Cancer Research: Insights Into Carcinogenesis, the Tumor Microenvironment, Metastasis, and Factors Influencing Prognosis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background The Department of Gastroenterological Surgery at Kumamoto University has maintained a commitment to integrating cutting‐edge clinical practice with fundamental research, particularly concerning malignant diseases of the digestive tract.
Hideo Baba, Takatsugu Ishimoto, Yoshifumi Baba, Hiromitsu Hayashi, Masaaki Iwatsuki   +4 more
wiley   +1 more source

Relationship Between the Product of Pre‐Treatment Neutrophil and Monocyte Counts and Clinical Outcomes in Rectal Cancer With Suspected Lateral Lymph Node Metastasis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim A novel systemic inflammatory response marker, the neutrophil × monocyte value (NM value), has been identified as a negative predictive factor for responses to chemoradiotherapy in rectal cancer. However, the clinical implications of the NM value remain unknown.
Takayoshi Sasaki, Shinya Abe, Hiroaki Nozawa, Kazuhito Sasaki, Koji Murono, Shigenobu Emoto, Yuichiro Yokoyama, Yuzo Nagai, Yuzo Harada, Soichiro Ishihara   +9 more
wiley   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

The Role and Potential Therapeutic Application of Myeloid-Derived Suppressor Cells in Allo- and Autoimmunity

Mediators of Inflammation, 2015
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that consists of myeloid progenitor cells and immature myeloid cells. They have been identified as a cell population that may affect the activation of CD4+ and CD8+ T-cells ...
Qi Zhang, Masayuki Fujino, Jinhua Xu, Xiao-kang Li   +3 more
doaj   +1 more source

Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma, Songyan Li, Jie Yan, Xuechun Wang, Wen Zhao, Yunxuan Song, Dongdong Liu, Jianwei Jiao, Xiuying Duan, Guiqiang Zhang   +9 more
wiley   +1 more source

Expression of the B-cell receptor component CD79a on immature myeloid cells contributes to their tumor promoting effects.

PLoS ONE, 2013
The role of myeloid derived suppressor cells (MDSCs) in promoting tumorigenesis is well-established, and significant effort is being made to further characterize surface markers on MDSCs both for better diagnosis and as potential targets for therapy ...
Dror Luger, Yu-An Yang, Asaf Raviv, Douglas Weinberg, Subhadra Banerjee, Min-Jung Lee, Jane Trepel, Li Yang, Lalage M Wakefield   +8 more
doaj   +1 more source

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, EarlyView.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source