Results 91 to 100 of about 4,990,718 (300)

Immunological responses to adjuvant vaccination with combined CD1c+ myeloid and plasmacytoid dendritic cells in stage III melanoma patients

OncoImmunology, 2022
We evaluated the immunological responses of lymph-node involved (stage III) melanoma patients to adjuvant dendritic cell vaccination with subsets of naturally occurring dendritic cells (nDCs).
Martine Bloemendal, Kalijn F. Bol, Steve Boudewijns, Mark A.J. Gorris, Johannes H.W. de Wilt, Sandra A.J. Croockewit, Michelle M. van Rossum, Anna L. de Goede, Katja Petry, Rutger H.T. Koornstra, Carl Figdor, Winald R. Gerritsen, Gerty Schreibelt, I. Jolanda M. de Vries   +13 more
doaj   +1 more source

Characterization of human metapneumovirus infection of myeloid dendritic cells

Virology, 2007
Recent in vivo studies suggest that hMPV is a poor inducer of inflammatory cytokines and that clinical symptoms may not be related to immune-mediated pathogenesis as it has been proposed for respiratory syncytial virus (RSV) and human parainfluenza 3 (HPF3).
Tan, MC, Battini, L, Tuyama, AC, Macip, S, Melendi, GA, Horga, MA, Gusella, GL   +6 more
openaire   +3 more sources

An Adipocyte MKK3–p38β Axis Preserves Insulin Responsiveness in Mice and Is Reciprocally Altered in Human Obesity

Advanced Science, EarlyView.
The adipocyte MKK3–p38β axis emerges as an adaptive stress‐response pathway during obesity. Human visceral adipose tissue analyses, adipocyte‐specific mouse models, and primary adipocytes show that the MKK3–p38β axis supports insulin responsiveness by restraining p70S6K‐dependent inhibitory IRS1 feedback and preserving AKT–GLUT4 signaling. This pathway
Edgar Bernardo, Nuria Matesanz, Jorge‐Luis Torres, Alba C. Arcones, Juan Ignacio Jiménez‐Loygorri, Alfonso Mora, Leticia Herrera‐Melle, Luis Leiva‐Vega, Maria Elena Rodriguez, Lourdes Hernández‐Cosido, Marta Leon, Paula Yong González, Teresa Durán, Tamara Parracho, Francisca Mulero, Rubén Nogueiras, J. Simon C. Arthur, Angel R. Nebreda, Roger J. Davis, Miguel Marcos, Guadalupe Sabio   +20 more
wiley   +1 more source

Functional Regulation of Ginsenosides on Myeloid Immunosuppressive Cells in the Tumor Microenvironment

Integrative Cancer Therapies, 2019
Ginsenosides, the key components isolated from ginseng, have been extensively studied in antitumor treatment. Numerous studies have shown that ginsenosides have direct function in tumor cells through the induction of cancer cell apoptosis and the ...
Yanfei Zhang MS, Zhidong Qiu PhD, Ye Qiu PhD, Ting Su MS, Peng Qu PhD, Ailing Jia PhD   +5 more
doaj   +1 more source

Principles of dendritic cell-based immunotherapy in myeloid leukemia

Immunobiology, 2006
Persistent presence of minimal residual disease in myeloid leukemia carries the risk of a relapse of the disease. In the setting of allogeneic transplants, leukemic cells have been proven to be susceptible to the action of immunocompetent T cells. Thus, an immunotherapeutic approach might hold promise in the attempt to eradicate or control residual ...
Theresia M, Westers, Ilse, Houtenbos, Arjan A, van de Loosdrecht, Gert J, Ossenkoppele   +3 more
openaire   +2 more sources

IMMUNOTHERAPEUTIC ACTION OF T-BET GENE MODIFIED DENDRITIC CELLS [PDF]

, 2013
T-bet is a Type-1 transcription factor that regulates the development of Type-1 T cell and Type-1 anti-tumor immunity. T-bet expression in Dendritic Cells (DC) is required for the ability of these antigen-presenting cells (APC) to prime Type-1-polarized ...
Chen, Lu
core  

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Targeting immune checkpoints on myeloid cells: current status and future directions

Cancer Immunology, Immunotherapy
Myeloid cells accumulate extensively in most tumors and play a critical role in immunosuppression of the tumor microenvironment (TME). Like T cells, myeloid cells also express immune checkpoint molecules, which induce the immunosuppressive phenotype of ...
Chuhan Ma, Yang Li, Min Li, Chao Lv, Yu Tian   +4 more
doaj   +1 more source

Hemozoin Enhances Maturation of Murine Bone Marrow Derived Macrophages and Myeloid Dendritic Cells [PDF]

Iranian Journal of Immunology, 2016
Background: Falciparum malaria is a severe health burden worldwide. Antigen presenting cells are reported to be affected by erythrocytic stage of the parasite. Malarial hemozoin (HZ), a metabolite of malaria parasite, has adjuvant properties and may play
Shahid Waseem, Kashif-Ur-Rehman -, Ramesh Kumar, Tariq Mahmood   +3 more
doaj  

Stabilization of acute myeloid leukemia with a dendritic cell vaccine

Hematology/Oncology and Stem Cell Therapy, 2008
Hematol Oncol Stem Cell Ther 1(4) October 2008 hemoncstem.edmgr.com 239 Acute myelogenous leukemia (AML), the most common adult acute leukemia, is characterized by the clonal expansion of myeloblasts initiati ing from rare leukemic stem cells.1 An estimated 31 490 new cases of AML and 45 090 deaths due to this disi ease occurred in 2008 in the US.2 ...
Massumoto, Celso, Sousa-Canavez, Juliana M., Camara-Lopes, Luiz H., Leite, Katia R.M.   +3 more
openaire   +2 more sources