Results 81 to 90 of about 4,660,604 (252)

Synthetic Toll‐Like Receptors for Control of Innate Immunity With Far‐Red Light

Advanced Science, EarlyView.
Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Anna V. Leopold, Vladislav V. Verkhusha
wiley   +1 more source

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

Caffeine affects the biological responses of human hematopoietic cells of myeloid lineage via downregulation of the mTOR pathway and xanthine oxidase activity [PDF]

, 2015
Correction of human myeloid cell function is crucial for the prevention of inflammatory and allergic reactions as well as leukaemia progression. Caffeine, a naturally occurring food component, is known to display anti-inflammatory effects which have ...
Sumbayev, Vadim V., Gibbs, Bernhard F, Yasinska, Inna M., Sumbayev, Vadim V, Casely-Hayford, Maxwell A., Gibbs, Bernhard F., Vadim V. Sumbayev, Berger, Steffen M., Maryam Abooali, Prokhorov, Alexandr, Yasinska, Inna M, Abooali, Maryam, Berger, Steffen Michael, Isabel Gonçalves Silva, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Fasler-Kan, Elizaveta, Alexandr Prokhorov, Gonçalves Silva, Isabel, Casely-Hayford, Maxwell A, Maxwell A. Casely-Hayford, Inna M. Yasinska, Steffen M. Berger   +22 more
core   +2 more sources

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Paradigm shift in dendritic cell-based immunotherapy: from in vitro generated monocyte-derived DCs to naturally circulating DC subsets

Frontiers in Immunology, 2014
Dendritic cell-based immunotherapy employs the patients’ immune system to fight neoplastic lesions spread over the entire body. This makes it an important therapy option for patients suffering from metastatic melanoma, which is often resistant to ...
Florian eWimmers, Gerty eSchreibelt, Annette E. Sköld, Carl G. Figdor, I. Jolanda M. ede Vries, I. Jolanda M. ede Vries   +5 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Dendritic cell function in the setting of chronic hepatitis c infection and changes during antiviral treatment [PDF]

, 2009
The role of the innate immune system and in particular of dendritic cells, in the establishment of chronic hepatitis C has been studied quite extensively over the last few years but controversy remains as to whether a potential virus-induced defect in
Pachiadakis, I.
core  

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Mechanisms and consequences of reduced dendritic growth of cerebellar Purkinje cells [PDF]

, 2012
The cerebellum is a brain region crucial for coordination and motor learning. Being the principal output cell of the cerebellar cortex, Purkinje cell loss and degeneration play an important role in many cerebellar diseases.
Gugger, Olivia S.
core   +1 more source

IL-4 downregulates gap junction protein connexin 26 to promote HIV-1 infection in macrophages

mBio
Macrophages and dendritic cells (DCs) are important targets for HIV-1 replication in vivo. Myeloid cells are collectively more resistant to HIV-1 infection than CD4+ T lymphocytes, but interleukin (IL)-4 has been observed to promote macrophage ...
Shumei Wang, Jingjing Zhang, Yuan Liu, Li Zhao, Yimin Zhang, Guoxin Liang, Hong Shang   +6 more
doaj   +1 more source