Results 261 to 270 of about 4,990,718 (300)

Dendritic Cell-Based Immunotherapy of Acute Myeloid Leukemia [PDF]

Journal of Clinical Medicine, 2019
Acute myeloid leukemia (AML) is a type of blood cancer characterized by the uncontrolled clonal proliferation of myeloid hematopoietic progenitor cells in the bone marrow. The outcome of AML is poor, with five-year overall survival rates of less than 10% for the predominant group of patients older than 65 years.
Marion Subklewe, Sébastien Anguille, Eva Lion   +2 more
exaly   +4 more sources

Some of the next articles are maybe not open access.

Related searches:

CD1c(+) myeloid dendritic cells in myeloid neoplasia

Cytometry Part B: Clinical Cytometry, 2015
We determined the normal level and phenotype of CD1c(+) myeloid dendritic cells (MDCs) in blood and bone marrow and evaluated the level of CD1c(+) MDCs in 295 myeloid neoplasms. CD1c(+) MDCs were increased above the mean level of non‐neoplastic hospital controls in 18.0% (53/295) of myeloid malignancies, increased three standard deviations above the ...
Howard J, Meyerson, Ebenezer, Osei, Karen, Schweitzer, Georgetta, Blidaru, Alison, Edinger, June, Schlegelmilch, Amad, Awadallah, Tanu, Goyal   +7 more
openaire   +2 more sources

Functions of myeloid and lymphoid dendritic cells

Immunology Letters, 2000
The bone marrow derived dendritic cell (DC) is an essential antigen presenting cell (APC) for the initiation of primary, T cell based immune responses. DC are a heterogenous haematopoietic lineage, in that many subsets from different tissues show different surface phenotypes, but the ability to stimulate antigen specific naïve T cell proliferation ...
A D, McLellan, E, Kämpgen
openaire   +2 more sources

Differentiation of myeloid dendritic cells into CD8α-positive dendritic cells in vivo

Blood, 2000
AbstractBone marrow-derived dendritic cells (DC) represent a family of antigen-presenting cells (APC) with varying phenotypes. For example, in mice, CD8α+ and CD8α− DC are thought to represent cells of lymphoid and myeloid origin, respectively. Langerhans cells (LC) of the epidermis are typical myeloid DC; they do not express CD8α, but they do express ...
M, Merad, L, Fong, J, Bogenberger, E G, Engleman   +3 more
openaire   +2 more sources

Myeloid and plasmacytoid dendritic cells in induced sputum after allergen inhalation in subjects with asthma

Journal of Allergy and Clinical Immunology, 2010
Background: Dendritic cells are professional antigen presenting cells that mediate the response to inhaled allergens. In animal models, the induction and maintenance of allergic airway inflammation is primarily a function of myeloid dendritic cells ...
Gail M Gauvreau, Paul O'Byrne, Benny Dua
exaly   +2 more sources

The function of myeloid dendritic cells in rheumatoid arthritis

Rheumatology International, 2017
Rheumatoid arthritis (RA) is a systemic autoimmune disease that causes joint pain, inflammation, and loss of function. Disease pathogenesis involves activation and proliferation of autoreactive pro-inflammatory effector T cells. While the details of RA onset and progression remain controversial, dendritic cell (DC) numbers dramatically increase in the ...
Mary Beth, Yu, William H R, Langridge
openaire   +2 more sources

Dendritic cell vaccination in acute myeloid leukemia

Cytotherapy, 2012
The prognosis of patients with acute myeloid leukemia (AML) remains dismal, with a 5-year overall survival rate of only 5.2% for the continuously growing subgroup of AML patients older than 65 years. These patients are generally not considered eligible for intensive chemotherapy and/or allogeneic hematopoietic stem cell transplantation because of high ...
Anguille, Sébastien, Willemen, Yannick, Lion, Eva, Smits, Evelien L., Berneman, Zwi N.   +4 more
openaire   +3 more sources

Derivation of Dendritic Cells from Myeloid and Lymphoid Precursors

International Reviews of Immunology, 2001
The antigen presenting dendritic cells (DC) found in mouse and human lymphoid tissues are heterogeneous. Several subsets of mature DC have been described and these may correspond to distinct lineages. In this review, we present evidence obtained from a series of studies on the lineage origin of DC.
Katia Georgopoulos
exaly   +3 more sources

Differential requirement for DOCK2 in migration of plasmacytoid dendritic cells versus myeloid dendritic cells

Blood, 2008
Abstract The migratory properties of dendritic cells (DCs) are important for their functions. Although several chemokines and their receptors have been implicated in DC migration, the downstream signaling molecules are largely unknown.
Kazuhito, Gotoh, Yoshihiko, Tanaka, Akihiko, Nishikimi, Ayumi, Inayoshi, Munechika, Enjoji, Ryoichi, Takayanagi, Takehiko, Sasazuki, Yoshinori, Fukui   +7 more
openaire   +2 more sources

Stimulatory and Inhibitory Differentiation of Human Myeloid Dendritic Cells

Clinical Immunology, 2000
Dendritic cells (DCs) play a critical obligate role in presenting antigens to T cells for activation. In the process, upon antigen capture, DCs undergo maturation and become more stimulatory. Human myeloid DCs can be generated from various sources, including blood, bone marrow, and CD34(+) stem cells.
A, Chakraborty, L, Li, N G, Chakraborty, B, Mukherji   +3 more
openaire   +2 more sources