Results 271 to 280 of about 4,990,718 (300)

Human myeloid dendritic cells are refractory to tryptophan metabolites

Human Immunology, 2011
The enzyme indoleamine 2,3-dioxygenase (IDO) degrades the essential amino acid tryptophan and is expressed, among other cell types, in immune cells such as dendritic cells (DCs), monocytes, and macrophages. It has been shown that the activity of IDO has a broad regulatory function in the immune system by inhibiting effector T-cell responses, inducing ...
Dagmar, von Bubnoff, Helene, Wilms, Marina, Scheler, Manuela, Brenk, Susanne, Koch, Thomas, Bieber   +5 more
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IFN regulation and functions in myeloid dendritic cells

Cytokine & Growth Factor Reviews, 2008
A central issue in dendritic cells (DC) biology is to understand how type I IFNs modulate the immuno-regulatory properties of DC. In this review I will address this issue in light of the recent experimental evidence on the expression and function of these cytokines in myeloid DC.
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Dendritic Cell Development from Common Myeloid Progenitors

Annals of the New York Academy of Sciences, 2001
Abstract: Dendritic cells (DCs) are professional antigen‐presenting cells which both initiate adaptive immune responses and control tolerance to self‐antigens. It has been suggested that these different effects on responder cells depend on subsets of DCs arising from either myeloid or lymphoid hematopoietic origins. In this model, CD8α+ Mac‐1− DCs are
M G, Manz, D, Traver, K, Akashi, M, Merad, T, Miyamoto, E G, Engleman, I L, Weissman   +6 more
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Dendritic cells of myeloid lineage

Current Opinion in Organ Transplantation, 2014
Advances in surgery, patient management, and pharmacologic immunosuppression have reduced the incidence of acute allograft rejection. However, generation of therapies to promote donor-specific immunosuppression with minimal side-effects has proved to be a difficult task.
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FUNCTION OF MYELOID DENDRITIC CELLS

2012
Approximately 70% of patients infected with hepatitis C virus (HCV) develop chronic infection, which has been reported to be due to impaired specific T cell responses. Myeloid dendritic cells (mDCs) are potent antigen-presenting cells that regulate T cell responses, however their role during chronic hepatitis C (CHC) is not fully understood.
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Dendritic cell potentials of early lymphoid and myeloid progenitors

Blood, 2001
It has been proposed that there are at least 2 classes of dendritic cells (DCs), CD8α+ DCs derived from the lymphoid lineage and CD8α− DCs derived from the myeloid lineage. Here, the abilities of lymphoid- and myeloid-restricted progenitors to generate DCs are compared, and their overall contributions to the DC compartment are evaluated.
M G, Manz, D, Traver, T, Miyamoto, I L, Weissman, K, Akashi   +4 more
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Network of Myeloid and Plasmacytoid Dendritic Cells in Atopic Dermatitis

2007
Atopic dermatitis (AD) presents as a chronic relapsing skin disease with high prevalence in children. The typical distributed skin lesions make the clinical diagnosis of AD very simple and clear-cut in most of the cases. In contrast, the underlying mechanisms leading to the manifestation of AD are more than complex and consist of genetic components ...
Natalija, Novak, Wenming, Peng, Chunfeng, Yu   +2 more
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Myeloid dendritic cells type 2 in allergic asthma

Allergy, 2013
AbstractBackgroundMyeloid dendritic cells type 2 (mDC2s) are a new subtype of DCs identified in both the circulation and the lung and suggested to have a role in allergic asthma.MethodsCirculating mDC2s were enumerated in 19 healthy, 18 atopic nonasthmatic, 18 mild atopic asthmatic, and 16 moderate/severe atopic asthmatic subjects using flow cytometry ...
Dua, B., Smith, S., Kinoshita, T., Imaoka, H., Gauvreau, G., O'Byrne, P.   +5 more
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[Dendritic cells and acute myeloid leukemia].

Zhongguo shi yan xue ye xue za zhi, 2014
Dendritic cells can be derived from leukemia cells and normal precursor cells in the patients with acute myeloid leukemia (AML). Dendritic cells may capture leukemia antigen in bone marrow or lymph nodes, and present leukemia common antigen to stimulate proliferation of specific CD8(+) T cells, playing anti-leukemia effect. Dendritic cells for clinical
Zhan-Qiang, Zhang, Bin, Zhang, Hu, Chen
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Modified myeloid dendritic cells act as regulatory dendritic cells to induce anergic and regulatory T cells

Blood, 2003
To exploit a novel strategy to regulate T cell–mediated immunity, we established human and murine modified dendritic cells (DCs) with potent immunoregulatory properties (designed as regulatory DCs), which displayed moderately high expression levels of major histocompatibility complex (MHC) molecules and extremely low levels of costimulatory molecules ...
Katsuaki, Sato, Naohide, Yamashita, Masanori, Baba, Takami, Matsuyama   +3 more
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