Results 81 to 90 of about 7,352,857 (294)

Related CCR Translation from CpG Blocks Immunosuppression by Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice

, 2011
Related CCR Translation from CpG Blocks Immunosuppression by Myeloid-Derived Suppressor Cells in Tumor-Bearing ...
Helen Bauer (14981735), Philipp Bittner (13573382), Daniel Nörenberg (14981738), Georg Wedekind (14981741), Christine Zoglmeier (14981732), Nadja Sandholzer (2133463), Stefan Endres (384040), Moritz Rapp (14920814), Carole Bourquin (826230), David Anz (653655)   +9 more
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Upregulation of SOCS-1 by Nutlin-3 in acute myeloid leukemia cells but not in primary normal cells

Clinics, 2014
OBJECTIVE: It has been shown that SOCS-1 plays an important role in the proper control of cytokine/growth factor responses and acts as a tumor suppressor in acute myeloid leukemias.
Veronica Tisato, Alessia Norcio, Claudio Celeghini, Daniela Milani, Arianna Gonelli, Paola Secchiero   +5 more
doaj   +1 more source

Monocyte-Derived Suppressor Cells in Transplantation

, 2015
Myeloid-derived suppressor cells (MDSC) are cells of myeloid origin with enhanced suppressive function. They are negative regulators of the immune responses and comprise a heterogeneous mixture of immunosuppressive cells of monocytic (M-MDSC) and ...
Ochando, Jordi, Bronte, Vincenzo, Jordi Ochando, Patricia Conde, Conde, Patricia, Vincenzo Bronte   +5 more
core   +1 more source

Myeloid-Derived Suppressor Cells Participate in Preventing Graft Rejection [PDF]

, 2012
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells and have a tremendous potential to suppress immune responses. MDSCs accumulate during tumor progression, autoimmunity, chronic infection, transplantation, and other ...
Jianbin Xiang, Xiaodong Gu, Yan Wang, Zongyou Chen   +3 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Early Expansion of Monocytic Myeloid-Derived Suppressor Cells Predicts Survival in Sepsis and Is Possibly Associated With Activation of Endoplasmic Reticulum Stress Pathways

Frontiers in Bioscience-Landmark
Background:Sepsis is characterized by profound immune dysregulation, in which myeloid-derived suppressor cells (MDSCs) serve as key regulators of the host immune response.
Juanli Liu, Tana Wuren, Xiaoyan Song, Xue Sun, Siqing Ma, Rili Ge   +5 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Supplementary Data from Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma Recurrence

, 2022
Supplementary Data from Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma ...
T.L. Shirley Chiu (14962085), Chung-Mau Lo (14962091), Oscar W.H. Yeung (14962058), Hui Liu (14962064), Li Pang (14962055), Xinxiang Yang (14962073), Wenqi Qiu (14962079), Kevin T.P. Ng (14962061), Jiang Liu (14962070), Zhiwei Chen (14962088), Jiye Zhu (14962067), Tao Ding (14962076), Kwan Man (14950386), Yuewen Wang (14962082)   +13 more
core   +2 more sources

Phenotypical Characterization and Isolation of Tumor-Derived Mouse Myeloid-Derived Suppressor Cells

, 2021
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population composed of mature and immature cells of myeloid origin that play a major role in tumor progression by inhibiting the antitumor immune responses mediated by T cells.
Bronte V, Musiu C, Ugel S, Barouni RM, Canè S.   +4 more
core   +1 more source