Results 61 to 70 of about 7,352,857 (294)
Journal of International Medical ResearchBackground Endometrial carcinoma is a prevalent gynecologic malignancy with a relatively low survival rate. Emerging studies have demonstrated that crosstalk between group 2 innate lymphoid cells (ILC2s) and myeloid-derived suppressor cells drives tumor ...
Zhangyun Gong +12 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
EBioMedicine, 2020 Mycobacterium tuberculosis (M.tb) is likely the most successful human pathogen, capable of evading protective host immune responses and driving metabolic changes to support its own survival and growth.
Leigh A. Kotzé +7 more
doaj +1 more source
Granulocytic Myeloid-Derived Suppressor Cells in Cystic Fibrosis
Frontiers in Immunology, 2021 Cystic Fibrosis (CF) is a genetic disease that causes chronic and severe lung inflammation and infection associated with high rates of mortality.
Samantha L. Tucker +2 more
doaj +1 more source
Targeting Myeloid-Derived Suppressor Cells in Cancer Immunotherapy
, 2020 Myeloid-derived suppressor cells (MDSCs), which are activated under pathological conditions, are a group of heterogeneous immature myeloid cells. MDSCs have potent capacities to support tumor growth via inhibition of the antitumoral immune response and ...
Yufei Wang +7 more
core +1 more source
Myeloid‐derived suppressor cells in malignant melanoma [PDF]
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 2014 SummaryMelanoma is known for its rapid progression, metastasis to distant organs and therapeutic resistance. Despite high melanoma immunogenicity, the results of immunotherapeutic clinical studies are mostly unsatisfactory. One explanation is the development of strong immunosuppression mediated by highly immunosuppressive regulatory leukocytes, in ...
Viktor, Umansky +3 more
openaire +2 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Myeloid-Derived Suppressor Cells in Inflammatory Bowel Disease [PDF]
Intestinal Research, 2015 Immature myeloid cells, also known as myeloid-derived suppressor cells (MDSCs), include neutrophilic and monocytic myeloid cells, and are found in inflammatory loci and secondary lymphoid organs in mice with intestinal inflammation, inflammatory bowel ...
Yeon-Jeong Kim +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Acta AngiologicaINTRODUCTION: Atherosclerosis and its complications are widespread and create a substantial burden for the healthcare system. The development and course of atherosclerosis are modulated by metabolic factors on the one hand and inflammation on the other ...
Michał Konrad Zarobkiewicz +6 more
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