Results 41 to 50 of about 7,352,857 (294)

Murine gammaherpesvirus-68 expands, but does not activate, CD11b⁺ gr-1⁺ splenocytes in vivo

Journal of Inflammation, 2012
Background Murine gammaherpesvirus 68 (HV-68) is an efficient pathogen, capable of infecting and establishing lifelong latency in rodents. While many studies have demonstrated the ability of this viral infection to modulate immune responses, a unifying ...
Nelson Daniel A, Chauhan Vinita S, Tolbert Melanie D, Bost Kenneth L   +3 more
doaj   +1 more source

On the origin of myeloid-derived suppressor cells

Oncotarget, 2016
Myeloid-derived suppressor cells (MDSCs) have a strong immunosuppressive character that allows them to regulate immune responses and hinder overt inflammatory responses. In cancer, this leads to tumor immune evasion and disease progression. MDSCs come in at least two forms: monocytic (Mo-MDSCs) and granulocytic (G-MDSCs).
Millrud, Camilla Rydberg, Bergenfelz, Caroline, Leandersson, Karin   +2 more
openaire   +3 more sources

The downregulation of type I IFN signaling in G-MDSCs under tumor conditions promotes their development towards an immunosuppressive phenotype

Cell Death and Disease, 2022
Tumors modify myeloid cell differentiation and induce an immunosuppressive microenvironment. Granulocytic myeloid-derived suppressor cells (G-MDSCs), the main subgroup of myeloid-derived suppressor cells (MDSCs), are immature myeloid cells (IMCs) with ...
Yingying Sun, Xiaoqing Han, Chao Shang, Yawei Wang, Boya Xu, Shu Jiang, Yan Mo, Dake Wang, Yueshuang Ke, Xianlu Zeng   +9 more
doaj   +1 more source

Targeting myeloid-derived suppressor cells for cancer therapy

Cancer Biology & Medicine, 2021
The emergence and clinical application of immunotherapy is considered a promising breakthrough in cancer treatment. According to the literature, immune checkpoint blockade (ICB) has achieved positive clinical responses in different cancer types, although
Hongchao Tang, Hao Li, Zhijun Sun
doaj   +1 more source

The contribution of bone marrow-derived cells to angiogenesis and lymphangiogenesis in murine models of carcinogenesis [PDF]

, 2009
Cancer is a class of diseases in which a group of cells display uncontrolled growth (division beyond the normal limits), invasion (intrusion on and destruction of adjacent tissues), and sometimes metastasis (spread to other locations in the body via ...
Zumsteg, Adrian
core   +1 more source

Role of myeloid-derived suppressor cells in hormone-dependent cancers

, 2021
Tumour-infiltrating myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of myeloid cells. The main feature of MDSCs is their ability to suppress T-cell activation and function, which leads to immunosuppressive activity in the tumour ...
Angela R. Elia, Arianna Calcinotto, Siddhartha Mukherjee   +2 more
core   +1 more source

Myeloid-Derived Suppressor Cells in Trypanosoma cruzi Infection

Frontiers in Cellular and Infection Microbiology, 2021
Myeloid-derived suppressor cells (MDSCs) are immature heterogeneous myeloid cells that expand in pathologic conditions as cancer, trauma, and infection.
Manuel Fresno, Manuel Fresno, Núria Gironès, Núria Gironès   +3 more
doaj   +1 more source

In Vitro 3D Staphylococcus aureus Abscess Communities Induce Bone Marrow Cells to Expand into Myeloid-Derived Suppressor Cells [PDF]

, 2021
Staphylococcus aureus is the main causative pathogen of subcutaneous, bone, and implant-related infections, forming structures known as staphylococcal abscess communities (SACs) within tissues that also contain immunosuppressive myeloid-derived ...
T. Fintan Moriarty, Hofstee, Marloes I, Häckel, Sonja, Anja Heider, Sebastian A. J. Zaat, Martijn Riool, Riool, Martijn, Marloes I. Hofstee, R. Geoff Richards, Richards, R Geoff, Caroline Constant, Constant, Caroline, Sonja Häckel, Heider, Anja, Zaat, Sebastian A J, Moriarty, T Fintan   +15 more
core   +2 more sources

The effect of conditioned media on the cellular proliferation of pancreatic cancer cells, pancreatic stellate cells, and myeloid-derived suppressor cells [PDF]

World Cancer Research Journal
Objective: Pancreatic cancer has remained one of the most devastating diseases over the past two decades, with minimal improvements in survival rates. Its highly immunosuppressive tumour microenvironment is driven by secreted proteins, such as cytokines ...
Y. Chong, S. Samsudin, D. Bahrani, C. Chang, A. Masamune, S. Ng, N. Ismail, K. Ho   +7 more
doaj   +1 more source

Chemotherapeutic targeting of myeloid-derived suppressor cells [PDF]

OncoImmunology, 2014
Myeloid-derived suppressor cells (MDSCs), which expand in cancer-bearing hosts, contribute to the escape of malignant cells from immune destruction and impair the efficacy of immunotherapeutic interventions. We have recently demonstrated that the conventional chemotherapeutic agent doxorubicin selectively eliminates MDSCs, hence promoting the activity ...
Alizadeh, Darya, Katsanis, Emmanuel, Larmonier, Nicolas   +2 more
openaire   +2 more sources