Beyond the immune suppression: the immunotherapy in prostate cancer [PDF]
, 2015 Prostate cancer (PCa) is the second most common cancer in men.Aswell in many other human cancers, inflammation and immune suppression have an important role in their development.We briefly describe the host components that interact with the tumor to ...
Agliano', Anna Maria +4 more
core +3 more sources
Role of Rip2 in development of tumor-infiltrating MDSCs and bladder cancer metastasis. [PDF]
, 2014 Tumor invasion and metastases represent a complex series of molecular events that portends a poor prognosis. The contribution of inflammatory pathways mediating this process is not well understood. Nod-like receptors (NLRs) of innate immunity function as
Chin, Arnold I, Zhang, Hanwei
core +2 more sources
Tumor-Induced Myeloid-Derived Suppressor Cells
Microbiology Spectrum, 2016 ABSTRACTMyeloid-derived suppressor cells (MDSCs) represent a heterogeneous, immune-suppressive leukocyte population that develops systemically and infiltrates tumors. MDSCs can restrain the immune response through different mechanisms including essential metabolite consumption, reactive oxygen and nitrogen species production, as well as display of ...
DE SANCTIS, FRANCESCO +2 more
openaire +4 more sources
Regulatory immune cells in transplantation [PDF]
, 2012 Immune regulation is fundamental to any immune response to ensure that it is appropriate for the perceived threat to the host. Following cell and organ transplantation, it is essential to control the innate immune response triggered by the injured ...
Bushell, Andrew +2 more
core +1 more source
Toca 511 gene transfer and treatment with the prodrug, 5-fluorocytosine, promotes durable antitumor immunity in a mouse glioma model. [PDF]
, 2017 BackgroundToca 511 (vocimagene amiretrorepvec) is a retroviral replicating vector encoding an optimized yeast cytosine deaminase (CD). Tumor-selective expression of CD converts the prodrug, 5-fluorocytosine (5-FC), into the active chemotherapeutic, 5 ...
Gruber, Harry E +9 more
core +1 more source
Targeting myeloid-derived suppressor cells for cancer therapy
Cancer Biology & Medicine, 2021 The emergence and clinical application of immunotherapy is considered a promising breakthrough in cancer treatment. According to the literature, immune checkpoint blockade (ICB) has achieved positive clinical responses in different cancer types, although
Hongchao Tang, Hao Li, Zhijun Sun
doaj +1 more source
Tailored design of NKT-stimulatory glycolipids for polarization of immune responses. [PDF]
, 2017 Natural killer T (NKT) cell is a distinct population of T lymphocytes that can rapidly release massive amount of Th1 and Th2 cytokines upon the engagement of their T cell receptor with glycolipids presented by CD1d.
Huang, Jing-Rong +2 more
core +2 more sources
Myeloid-Derived Suppressor Cells in Trypanosoma cruzi Infection
Frontiers in Cellular and Infection Microbiology, 2021 Myeloid-derived suppressor cells (MDSCs) are immature heterogeneous myeloid cells that expand in pathologic conditions as cancer, trauma, and infection.
Manuel Fresno +3 more
doaj +1 more source
Role of mTOR signaling in tumor microenvironment. An overview [PDF]
, 2018 The mammalian target of rapamycin (mTOR) pathway regulates major processes by integrating a variety of exogenous cues, including diverse environmental inputs in the tumor microenvironment (TME).
Bazzichetto, Chiara +8 more
core +2 more sources
The effect of conditioned media on the cellular proliferation of pancreatic cancer cells, pancreatic stellate cells, and myeloid-derived suppressor cells [PDF]
World Cancer Research JournalObjective: Pancreatic cancer has remained one of the most devastating diseases over the past two decades, with minimal improvements in survival rates. Its highly immunosuppressive tumour microenvironment is driven by secreted proteins, such as cytokines ...
Y. Chong +7 more
doaj +1 more source