Results 21 to 30 of about 7,352,857 (294)

Targeting myeloid-derived suppressor cells augments antitumor activity against lung cancer

ImmunoTargets and Therapy, 2012
Minu K Srivastava,1,2 Li Zhu,1,2 Marni Harris-White,2 Min Huang,1–3 Maie St John,1,3 Jay M Lee,1,3 Ravi Salgia,4 Robert B Cameron,1,3,5 Robert Strieter,6 Steven Dubinett,1–3 Sherven Sharma1–31Department of Medicine, UCLA Lung Cancer ...
Srivastava MK, Zhu L, Harris-White M, Huang M, St John M, Lee JM, Salgia R, Cameron RB, Strieter R, Dubinett S, Sharma S   +10 more
doaj   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid-derived suppressor cells. [PDF]

FEBS Open Bio
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Chen Y, Li H.
europepmc   +2 more sources

EBV and myeloid-derived suppressor cells [PDF]

Blood, 2021
In this issue of Blood, Collins et al have developed a novel multicolor flow cytometry technology to reveal a crucial role of myeloid-derived suppressor cells in Epstein-Barr virus (EBV)-associated lymphoproliferative diseases. In particular this study focuses on EBV-positive natural killer (NK) cell and T-cell proliferation.(1)
Debottam Sinha, Rajiv Khanna
openaire   +4 more sources

Myeloid derived suppressor cells [PDF]

OncoImmunology, 2013
The goal of achieving measurable response with cancer immunotherapy requires counteracting the immunosuppressive characteristics of tumors. One of the mechanisms that tumors utilize to escape immunosurveillance is the activation of myeloid derived suppressor cells (MDSCs).
Waldron, Todd J., Quatromoni, Jon G., Karakasheva, Tatiana A., Singhal, Sunil, Rustgi, Anil K.   +4 more
openaire   +2 more sources

Myeloid-derived suppressor cells in cancer

iLIVER, 2022
Numerous recent studies have shown that myeloid-derived suppressor cells (MDSCs), a strongly heterogeneous population of immunosuppressive cells, are dysregulated in the presence of many cancers. MDSCs present different phenotypes and play prominent roles in the tumor microenvironment. To date, gene therapies targeting MDSCs are the most innovative and
Gao, Jun, Liu, Wei-Ren, Tang, Zheng, Fan, Jia, Shi, Ying-Hong   +4 more
openaire   +2 more sources

Myeloid-Derived Suppressor Cells [PDF]

Viral Immunology, 2017
AbstractMyeloid cells developed evolutionarily as a major mechanism to protect the host. They evolved as a critical barrier against infections and are important contributors to tissue remodeling. However, in cancer, myeloid cells are largely converted to serve a new master—tumor cells.
openaire   +4 more sources

Neutrophils as myeloid‐derived suppressor cells [PDF]

European Journal of Clinical Investigation, 2018
AbstractNeutrophils form the first line of defence against invading pathogens, such as bacteria and fungi, as part of the innate immune response. Recently, neutrophils have also been discovered as repressors of adaptive immune responses. Under certain conditions, such as cancer and severe injury, an expansion of immature and mature neutrophils has been
Cathelijn E. M. Aarts, Taco W. Kuijpers
openaire   +2 more sources

Myeloid-Derived Suppressor Cells in Sepsis [PDF]

BioMed Research International, 2014
Sepsis is a systemic, deleterious host response to widespread infection. Patients with sepsis will have documented or suspected infection which can progress to a state of septic shock or acute organ dysfunction. Since sepsis is responsible for nearly 3 million cases per year in China and severe sepsis is a common, expensive fatal condition in America ...
Dengming Lai, Chaojin Qin, Qiang Shu
openaire   +2 more sources

Polyphenon E enhances the antitumor immune response in neuroblastoma by inactivating myeloid suppressor cells [PDF]

, 2013
This is the author's accepted manuscript. The final published article is available from the link below. Note: In this manuscript as well as in the original published version of this article the word "Polyphenon" was incorrectly spelled in the title as ...
Chayka, O, Sala, A, Piotrowska, I, Himoudi, N, D'Alicarnasso, M, Cantilena, S, Santilli, G, Morgenstern, DA, Thrasher, AJ, Pearson, K, Anderson, J   +10 more
core   +1 more source

Myeloid-Derived Suppressor Cells (MDSCs) in Haematology

, 2021
Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells with immunomodulating properties, mainly acting by suppressing T-cell responses [...
Nikoleta Bizymi, Helen A. Papadaki
core   +1 more source