Results 161 to 170 of about 19,949 (187)

Tumor necrosis factor‐alpha inhibits myogenic differentiation through MyoD protein destabilization

FASEB Journal, 2004
Tumor necrosis factor α (TNFα) has been implicated as a mediator of muscle wasting through nuclear factor kappa B (NF‐ΚB) ‐dependent inhibition of myogenic differentiation. The aim of the present study was to identify the regulatory molecule(s) of myogenesis targeted by TNFα/NF‐κΒ signaling. TNFα interfered with cell cycle exit and
Annemie Schols, Yvonne Janssen-Heininger, Ramon Langen   +2 more
exaly   +3 more sources

Efficient myogenic differentiation of human adipose-derived stem cells by the transduction of engineered MyoD protein

Biochemical and Biophysical Research Communications, 2013
Human adipose-derived stem cells (hASCs) have great potential as cell sources for the treatment of muscle disorders. To provide a safe method for the myogenic differentiation of hASCs, we engineered the MyoD protein, a key transcription factor for myogenesis.
Doo-Byoung Oh, Ki-Sun Kwon, Ohsuk Kwon   +2 more
exaly   +3 more sources

MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels

Science, 2023
Piezo channels are critical cellular sensors of mechanical forces. Despite their large size, ubiquitous expression, and irreplaceable roles in an ever-growing list of physiological processes, few Piezo channel–binding proteins have emerged. In this work, we found that MyoD (myoblast determination)–family inhibitor proteins (MDFIC and MDFI) are PIEZO1/2
Zijing Zhou, Xiaonuo Ma, Yiechang Lin, Delfine Cheng, Navid Bavi, Genevieve A. Secker, Jinyuan Vero Li, Vaibhao Janbandhu, Drew L. Sutton, Hamish S. Scott, Mingxi Yao, Richard P. Harvey, Natasha L. Harvey, Ben Corry, Yixiao Zhang, Charles D. Cox   +15 more
openaire   +3 more sources

Nuclear import of the myogenic factor MyoD requires cAMP-dependent protein kinase activity but not the direct phosphorylation of MyoD

Journal of Cell Science, 1994
ABSTRACT MyoD is a nuclear phosphoprotein that belongs to the family of myogenic regulatory factors and acts in the tran-scriptional activation of muscle-specific genes. We have investigated the role of cAMP-dependent protein kinase (A-kinase) in modulating the nuclear locale of MyoD.
M, Vandromme, G, Carnac, C, Gauthier-Rouvière, D, Fesquet, N, Lamb, A, Fernandez   +5 more
openaire   +2 more sources

Activation of Xenopus MyoD Transcription by Members of the MEF2 Protein Family

Developmental Biology, 1994
Members of the MEF2 family of DNA binding proteins interact with a set of AT-rich sequences commonly found in the promoters and enhancers of muscle-specific genes. We have shown that a MEF2 binding site precisely overlaps the TFIID binding site (TATA box) in the Xenopus MyoDa (XMyoDa) promoter and appears to play an important role in muscle-specific ...
M W, Wong, M, Pisegna, M F, Lu, D, Leibham, M, Perry   +4 more
openaire   +2 more sources

Interplay between two myogenesis-related proteins: TBP-interacting protein 120B and MyoD

Gene, 2012
Gene expression in myogenesis is governed by multiple myogenic factors including MyoD. Previously, we demonstrated that TBP-interacting protein 120B (TIP120B) promotes in vitro myogenesis through its anti-ubiquitination ability. In this study, we investigated interplay between MyoD and TIP120B.
Hidefumi, Suzuki, Ai, Suzuki, Yui, Maekawa, Seiji, Shiraishi, Taka-aki, Tamura   +4 more
openaire   +2 more sources

The adaptive response of MyoD family proteins in overloaded, regenerating and denervated rat muscles

Biochimica et Biophysica Acta (BBA) - General Subjects, 1999
Using Western blot analysis, we investigated whether the amount of myogenic regulatory factors differs in slow-type and fast-type muscles. In addition, we examined the adaptive response of myogenic regulatory factor protein in the overloaded rat muscles by the ablation of synergists, in the regenerating muscles following bupivacaine injection and in ...
Sakuma K, Watanabe K, Sano M, Sakamoto K, Uramoto I, Totsuka T   +5 more
openaire   +2 more sources

Rapamycin-induced autophagy decreases Myf5 and MyoD proteins in C2C12 myoblast cells

Toxicology in Vitro, 2019
Rapamycin is an immunosuppressant that inhibits the mammalian or mechanistic target of rapamycin (mTOR) protein kinase and extends lifespan in organisms including mice. Myf5 and MyoD act as muscle-specific transcriptional factors for skeletal muscle differentiation. In this study, we determined whether rapamycin-induced autophagy causes the decrease of
Yeong-Min Yoo, Eui-Man Jung, Eui-Bae Jeung   +2 more
openaire   +2 more sources

Functional antagonism between c-Jun and MyoD proteins: A direct physical association

Cell, 1992
The product of the proto-oncogene Jun inhibits myogenesis. Constitutive expression of Jun in myoblasts interferes with the expression and the function of MyoD protein. In transient transfection assays Jun inhibits transactivation of the MyoD promoter, the muscle creatine kinase enhancer, and a reporter gene linked to MyoD DNA-binding sites. Conversely,
E, Bengal, L, Ransone, R, Scharfmann, V J, Dwarki, S J, Tapscott, H, Weintraub, I M, Verma   +6 more
openaire   +2 more sources

Interaction of the porcine reproductive and respiratory syndrome virus nucleocapsid protein with the inhibitor of MyoD family-a domain-containing protein

bchm, 2008
Abstract Porcine reproductive and respiratory syndrome (PRRS) virus is an RNA virus that replicates in the cytoplasm, but the viral nucleocapsid (N) protein localizes specifically in the nucleus and nucleolus of virus-infected cells. Nuclear localization of N is non-essential for PRRSV replication in cultured cells but has been shown to ...
Cheng, Song, Ray, Lu, Dorothee, Bienzle, Hsiao-Ching, Liu, Dongwan, Yoo   +4 more
openaire   +2 more sources