Results 171 to 180 of about 19,949 (187)

Regulation of Muscle Cell Growth and Differentiation by the Myod Family of Helix-Loop-Helix Proteins

1992
The skeletal muscle cell system provides a powerful model for exploring the mechanistic basis for the antagonism between cell growth and differentiation. The recent identification of the MyoD family of muscle-specific transcription factors now offers opportunities to dissect at the molecular level of the mechanisms through which defined cell type ...
L, Li, E N, Olson
openaire   +2 more sources

Affinity of synthetic peptide fragments of MyoD for Id1 protein and their biological effects in several cancer cells

Journal of Peptide Science, 2010
AbstractMyoD is a DNA‐binding protein capable of specific interactions that involve the helix–loop–helix (HLH) domain. The HLH motif of MyoD can form oligomers with the HLH motif of Id1 (the inhibitor of DNA‐binding proteins) that folds into a highly stable helical conformation stabilized by the self‐association.
Chiu-Heng, Chen, Sheng-Chu, Kuo, Li-Jiau, Huang, Mei-Hua, Hsu, Feng-Di T, Lung   +4 more
openaire   +2 more sources

EID-2, a novel member of the EID family of p300-binding proteins inhibits transactivation by MyoD

Gene, 2003
Skeletal muscle differentiation has been shown to be dependent on the expression of Rb and p300. We recently cloned a novel inhibitor of muscle differentiation called EID-1, which interacted with both of these factors. In a database search for related molecules, we have cloned and characterized a new EID-1 family member, EID-2.
Aimin, Ji, Diem, Dao, Jiexiao, Chen, W Robb, MacLellan   +3 more
openaire   +2 more sources

Regulation of MyoD gene transcription and protein function by the transforming domains of the adenovirus E1A oncoprotein.

Oncogene, 1993
It has been demonstrated that the adenovirus E1A gene products inhibit myogenic differentiation in the mouse C2 muscle cell line. During myogenic differentiation, cell growth and tissue-specific gene expression are mutually exclusive. Since E1A exerts multiple effects on different cellular pathways through alteration of cell growth control and ...
Maurizia Caruso, Fabio Martelli, Carlo Cenciarelli, Armando Felsani   +3 more
openaire   +3 more sources

Mitogen-activated Protein Kinase Kinase 1 (MEK1) Stabilizes MyoD through Direct Phosphorylation at Tyrosine 156 During Myogenic Differentiation

Journal of Biological Chemistry, 2011
Sun-Jung Cho, Sangmee Ahn Jo
exaly  

MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer

Cell, 1989
Andrew Lassar, Stephen D Hauschka, Jean N Buskin   +2 more
exaly  

MyoD protein accumulates in satellite cells and is neurally regulated in regenerating myotubes and skeletal muscle fibers

Developmental Dynamics, 1995
Ming Zhang, I S Mclennan
exaly  

Molecular mechanisms of transcriptional activation by the BHLH protein MyoD.

2014
openaire   +1 more source

MyoD protein is differentially accumulated in fast and slow skeletal muscle fibres and required for normal fibre type balance in rodents

Mechanisms of Development, 1997
Simon M Hughes, Michael A Rudnicki, Kyoko Koishi   +2 more
exaly  

A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein

EMBO Journal, 1998
Aaron Ciechanover, Arie Admon, Eyal Bengal   +2 more
exaly