Results 21 to 30 of about 1,800 (131)
Scientific Reports, 2021 Muscular dystrophies are disorders characterized by progressive muscle loss and weakness that are both genotypically and phenotypically heterogenous. Progression of muscle disease arises from impaired regeneration, plasma membrane instability, defective ...
David Y. Barefield +5 more
doaj +1 more source
Expression of myoferlin in human airway epithelium and its role in cell adhesion and zonula occludens-1 expression. [PDF]
PLoS ONE, 2012 Normal airway epithelial barrier function is maintained by cell-cell contacts which require the translocation of adhesion proteins at the cell surface, through membrane vesicle trafficking and fusion events.
Cleo Leung +3 more
doaj +1 more source
Fluorescent Flippers: Small‐Molecule Probes to Image Membrane Tension in Living Systems
Angewandte Chemie, Volume 135, Issue 20, May 8, 2023., 2023 The emergence of fluorescent flippers as membrane tension probes is described in the context of the general challenge to create chemistry tools to image physical forces in living systems. Abstract Flipper probes have been introduced as small molecule fluorophores to image physical forces, that is, membrane tension in living systems.
Xiao‐Xiao Chen +5 more
wiley +2 more sources
A Macroscopic Mathematical Model For Cell Migration Assays Using A Real-Time Cell Analysis [PDF]
, 2016 Experiments of cell migration and chemotaxis assays have been classically performed in the so-called Boyden Chambers. A recent technology, xCELLigence Real Time Cell Analysis, is now allowing to monitor the cell migration in real time.
Angelini, Claudia +5 more
core +5 more sources
Clinical and Translational Medicine, 2021 As a pivotal vesicular trafficking protein, Myoferlin (MYOF) has become an attractive target for cancer therapy. However, the roles of MYOF in colorectal cancer invasion remain enigmatic, and MYOF‐targeted therapy in this malignancy has not been explored.
Yuan He +12 more
doaj +1 more source
Solution structure of the inner DysF domain of myoferlin and implications for limb girdle muscular dystrophy type 2b [PDF]
, 2008 Mutations in the protein dysferlin, a member of the ferlin family, lead to limb girdle muscular dystrophy type 2B and Myoshi myopathy. The ferlins are large proteins characterised by multiple C2 domains and a single C-terminal membrane-spanning helix ...
Achanzar +70 more
core +1 more source
Journal of Extracellular Vesicles, Volume 12, Issue 12, December 2023., 2023 Abstract Periodontitis is a chronic inflammatory disease caused by periodontal pathogens in subgingival plaque and is associated with systemic inflammatory diseases. Extracellular vesicles (EVs) released from host cells and pathogens carry a variety of biological molecules and are of interest for their role in disease progression and as diagnostic ...
Younggap Lim +3 more
wiley +1 more source
Crystal structures of the human Dysferlin inner DysF domain [PDF]
, 2014 Background: Mutations in dysferlin, the first protein linked with the cell membrane repair mechanism, causes a group of muscular dystrophies called dysferlinopathies.
Cole, Ambrose R. +4 more
core +1 more source
Annexin‐A5 and annexin‐A6 silencing prevents metastasis of breast cancer cells in zebrafish
Biology of the Cell, Volume 115, Issue 6, June 2023., 2023 Invasive and metastatic cancer cells are exposed to major mechanical constraints, which may induce plasma membrane damages. We show that highly invasive breast cancer cells survive to these mechanical stresses thanks to annexin‐A5 (ANXA5) and ANXA6, which are two major players of the membrane repair machinery.
Céline Gounou +10 more
wiley +1 more source
Myoferlin controls mitochondrial structure and activity in pancreatic ductal adenocarcinoma, and affects tumor aggressiveness [PDF]
, 2018 Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related death. Therapeutic options remain very limited and are based on classical chemotherapies.
Bellahcene, Akeila +17 more
core +1 more source