Results 61 to 70 of about 1,800 (131)
Immunogenicity and Safety of Anti-SARS-CoV-2 mRNA Vaccines in a Cohort of Patients with Hereditary Angioedema [PDF]
, 2023 Many factors may trigger hereditary angioedema (HAE) attacks. This study aims to gain insights into the benefits and potential risks of COVID-19 vaccination in HAE patients, focusing particularly on the possibility of triggering attacks.
Alessandro Furno +8 more
core +1 more source
A small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer
Nature Communications, 2018 Improved therapeutics are needed for treating breast cancer. Here they show the druggability of myoferlin with a small molecule inhibitor in breast cancer and demonstrate its anti-breast cancer effects in vitro and in vivo.
Tao Zhang +11 more
doaj +1 more source
Loss of myoferlin redirects breast cancer cell motility towards collective migration.
PLoS ONE, 2014 Cell migration plays a central role in the invasion and metastasis of tumors. As cells leave the primary tumor, they undergo an epithelial to mesenchymal transition (EMT) and migrate as single cells.
Leonithas I Volakis +11 more
doaj +1 more source
Treatment of Hereditary Angioedema With Plasma‐Derived C1 Inhibitor: A Review
Clinical and Translational Allergy, Volume 15, Issue 12, December 2025.ABSTRACT Hereditary angioedema (HAE) is clinically characterized by recurrent episodes of localized edema. HAE typically occurs due to a deficiency of functional C1 inhibitor (C1INH, HAE‐C1INH); in addition, several types of HAE with normal quantity and activity of C1INH (HAE‐nC1INH) have recently been classified, which occur due to different gene ...
Inmaculada Martinez‐Saguer +3 more
wiley +1 more source
Breast Cancer Cell Adhesion Strength Following Lentivirus-Mediated Myoferlin Depletion [PDF]
, 2011 This project has earned the author the BME Senior Research Achievement AwardThe purpose of this project was to quantify the effect of lentiviral-based knockdown of myoferlinon the adhesion and spreading of MDA-MB-231 human breast cancer cells ...
Bechel, Meagan
core
Clinical and Translational Allergy, Volume 15, Issue 6, June 2025.Abstract Background Hereditary angioedema (HAE) is a rare, autosomal dominantly inherited disease characterised by mucocutaneous oedema attacks. Vasoactive mediators and the endothelium play an important role in the pathogenesis of HAE. We aimed to evaluate the endothelial dysfunction in HAE. Methods The study included 35 C1 inhibitor deficient (C1‐INH)
Gokce Gul Atay Sensoy +7 more
wiley +1 more source
, 2015 BACKGROUND: Hypertension is a complex disease with many contributory genetic and environmental factors. We aimed to identify common targets for therapy by gene expression profiling of a resistance artery taken from animals representing two different ...
Brackenbury, Therese +8 more
core +1 more source
The Journal of Dermatology, Volume 52, Issue 2, Page 256-269, February 2025.Abstract Hereditary angioedema (HAE) symptoms can vary greatly. Disease burden evaluation is essential for providing adequate treatments for patients. Patient‐reported outcome measures (PROMs), including the 12‐Item Short Form Health Survey (SF‐12), the Angioedema Quality of Life (AE‐QoL), the Hospital Anxiety and Depression Scale (HADS), and the Work ...
Michihiro Hide +6 more
wiley +1 more source
Mediators of Inflammation, Volume 2025, Issue 1, 2025.Background: Wilson’s disease (WD) is an abnormal copper metabolism disease. GanDouFuMu decoction (GDFMD) is a traditional Chinese medicine, whicn has shown good therapeutic effects in clinical treatment of WD liver fibrosis;but its regulatory mechanism is still unclear.
Peng Huang +10 more
wiley +1 more source
Ferlins Show Tissue-Specific Expression and Segregate as Plasma Membrane/Late Endosomal or Trans-Golgi/Recycling Ferlins [PDF]
, 2016 © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Ferlins are an ancient family of Ca2+-binding, multi-C2 domain vesicle fusion proteins.
Cooper, ST +4 more
core +1 more source