Results 71 to 80 of about 1,800 (131)

Size matters: Biomolecular compositions of small and large extracellular vesicles in the urine of glioblastoma patients

Journal of Extracellular Biology, Volume 3, Issue 11, November 2024.
Abstract The promise of urinary extracellular vesicles (uEVs) in biomarker discovery is emerging. However, the characteristics and compositions of different uEV subpopulations across normal physiological and pathological states require rigorous explication.
Susannah M. Hallal, Liam A. Sida, Ágota Tűzesi, Brindha Shivalingam, Hao‐Wen Sim, Michael E. Buckland, Laveniya Satgunaseelan, Kimberley L. Alexander   +7 more
wiley   +1 more source

Quantitative Proteome Reveals Variation in the Condition Factor of Sea Urchin Strongylocentrotus nudus during the Fishing Season Using an iTRAQ-based Approach

Marine Drugs, 2019
To investigate the variation in the condition factor of the sea urchin Strongylocentrotus nudus (S. nudus), gonads were collected in May (MAY), June (JUN), and July (JUL), at the beginning (AUG-b) and end of August (AUG-e).
Wen-Hui Shang, Jia-Run Han, Jia-Nan Yan, Yi-Nan Du, Yun-Sheng Xu, Chang-Feng Xue, Tie-Tao Zhang, Hai-Tao Wu, Bei-Wei Zhu   +8 more
doaj   +1 more source

Targeting lysosomal quality control as a therapeutic strategy against aging and diseases

Medicinal Research Reviews, Volume 44, Issue 6, Page 2472-2509, November 2024.
Abstract Previously, lysosomes were primarily referred to as the digestive organelles and recycling centers within cells. Recent discoveries have expanded the lysosomal functional scope and revealed their critical roles in nutrient sensing, epigenetic regulation, plasma membrane repair, lipid transport, ion homeostasis, and cellular stress response ...
Yuchen He, Yishu Fan, Xenab Ahmadpoor, Yumin Wang, Zhong Alan Li, Weihong Zhu, Hang Lin   +6 more
wiley   +1 more source

Targeting factor XIIa for therapeutic interference with hereditary angioedema

Journal of Internal Medicine, Volume 296, Issue 4, Page 311-326, October 2024.
Abstract Hereditary angioedema (HAE) is a rare, potentially life‐threatening genetic disorder characterized by recurrent attacks of swelling. Local vasodilation and vascular leakage are stimulated by the vasoactive peptide bradykinin, which is excessively produced due to dysregulation of the activated factor XII (FXIIa)‐driven kallikrein–kinin system ...
Danny M. Cohn, Thomas Renné
wiley   +1 more source

Algorithms in Allergy: Hereditary Angioedema

Allergy, EarlyView.
Konrad Bork, Markus Magerl, Emel Aygören‐Pürsün, Henriette Farkas   +3 more
wiley   +1 more source

Cancer EV stimulate endothelial glycolysis to fuel protein synthesis via mTOR and AMPKα activation

Journal of Extracellular Vesicles, Volume 13, Issue 7, July 2024.
Abstract Hypoxia is a common feature of solid tumours and activates adaptation mechanisms in cancer cells that induce therapy resistance and has profound effects on cellular metabolism. As such, hypoxia is an important contributor to cancer progression and is associated with a poor prognosis.
Joël E. J. Beaumont, Lydie M. O. Barbeau, Jinzhe Ju, Kim G. Savelkouls, Freek G. Bouwman, Marijke I. Zonneveld, Annelies Bronckaers, Kim R. Kampen, Tom G. H. Keulers, Kasper M. A. Rouschop   +9 more
wiley   +1 more source

Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosis [PDF]

, 2009
BACKGROUND: Melioidosis is a severe infectious disease caused by Burkholderia pseudomallei, a Gram-negative bacillus classified by the National Institute of Allergy and Infectious Diseases (NIAID) as a category B priority agent.
Banchereau, Jacques, Bancroft, Gregory J, Berry, Matthew, Blankenship, Derek M, Buddhisa, Surachat, Chaussabel, Damien, Lertmemongkolchai, Ganjana, Pankla, Rungnapa   +7 more
core   +3 more sources

Mitochondrial fusion–fission dynamics and its involvement in colorectal cancer

Molecular Oncology, Volume 18, Issue 5, Page 1058-1075, May 2024.
Disruption of the mitochondrial fusion–fission dynamics balance plays a dual role in colorectal cancer development. Mitochondrial fission promotes cancer cell proliferation, invasion, migration, and chemoresistance, while excessive fission induces apoptosis.
Zihong Wu, Chong Xiao, Fang Li, Wenbo Huang, Fengming You, Xueke Li   +5 more
wiley   +1 more source

Cell Invasion Dynamics into a Three Dimensional Extracellular Matrix Fibre Network [PDF]

, 2015
The dynamics of filopodia interacting with the surrounding extracellular matrix (ECM) play a key role in various cell-ECM interactions, but their mechanisms of interaction with the ECM in 3D environment remain poorly understood. Based on first principles,
Asada, Harry, Kamm, Roger Dale, Kim, Min-Cheol, Silberberg, Yaron R., Whisler, Jordan Ari   +4 more
core   +3 more sources

On the role of dysferlin in striated muscle: membrane repair, t‐tubules and Ca2+ handling

The Journal of Physiology, Volume 602, Issue 9, Page 1893-1910, 1 May 2024.
Abstract figure legend Cardiac and skeletal muscle share many structural and functional similarities and are both classified as striated muscle. Dysferlin plays a diverse role in supporting healthy striated muscle physiology. Due to its protective and regenerative capabilities, dysferlin is particularly important in response to muscle stress or damage.
C. J. Quinn, E. J. Cartwright, A. W. Trafford, K. M. Dibb   +3 more
wiley   +1 more source