Results 101 to 110 of about 33,732 (260)

Effect of NF‐κB on Myosin Heavy Chain Content and Muscle Atrophy After Laryngeal Muscle Denervation

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective To investigate the role of NF‐κB in regulating myosin heavy chain (MyHC) content and muscle atrophy following laryngeal muscle denervation. Methods Rats were divided into five groups: (1) recurrent laryngeal nerve injury (RLNI), (2) RLNI with NF‐κB inhibition, (3) sham operation, (4) sham operation with injection, and (5) blank ...
Jing‐Jing Yang, Rong Hu, Hai‐Zhou Wang, Xue‐Yan Li, Wen Xu   +4 more
wiley   +1 more source

Stable, covalent attachment of laminin to microposts improves the contractility of mouse neonatal cardiomyocytes. [PDF]

, 2014
The mechanical output of contracting cardiomyocytes, the muscle cells of the heart, relates to healthy and disease states of the heart. Culturing cardiomyocytes on arrays of elastomeric microposts can enable inexpensive and high-throughput studies of ...
Ashley, Euan A, Pruitt, Beth L, Ribeiro, Alexandre JS, Zaleta-Rivera, Kathia   +3 more
core   +2 more sources

Muscle Cathepsin B Treatment Improves Behavioral and Neurogenic Deficits in a Mouse Model of Alzheimer's Disease

Aging Cell, EarlyView.
Targeting muscle with Cathepsin B (Ctsb) to treat the AD mouse brain. In this study, an AAV‐vector‐mediated approach, utilized to express Ctsb in muscle, prevented mnemonic and neurogenic deficits and normalized hippocampal, muscle, and plasma proteomic profiles.
Alejandro Pinto, Hazal Haytural, Cássio Morais Loss, Claudia Alvarez, Asude Ertas, Olivia Curtis, Alyssa R. Williams, Grayson Murphy, Kenneth J. Salleng, Sylvia Gografe, Nishant P. Visavadiya, Andy V. Khamoui, Ali Altıntaş, Tal Kafri, Romain Barres, Atul S. Deshmukh, Henriette van Praag   +16 more
wiley   +1 more source

Taxa de crescimento e fragmentação Miofibrilar diferenciadas em ratos submetidos a restrição alimentar e realimentação [PDF]

, 2008
Feed regimens alter muscle growth rate, hence they might impact the proteolytic system involved in tenderization during meat conditioning. The aim of this project was to verify the effects of feed restriction regimens on muscular and animal growth and ...
BAGALDO, Adriana Regina, DELGADO, Eduardo Francisquine, LANNA, Dante Pazzanese Duarte, LEONARDO, Eric Franchi, PAZ, Claudia Cristina Paro de   +4 more
core   +3 more sources

Neural Organoids Protect Engineered Heart Tissues From Glucolipotoxicity by Transferring Versican in a Co‐Culture System

Cell Proliferation, EarlyView.
In this study, Bai et al. established a co‐culture system between neural organoids (NOs) and engineered heart tissues (EHTs) and demonstrated that NOs could secrete versican, which was absorbed by EHTs to ameliorate glucolipotoxicity. ABSTRACT Metabolic disorders could cause dysregulated glucose and lipid at the systemic level, but how inter‐tissue ...
Baochen Bai, Jiting Li, Ze Wang, Yuhan Yang, Jieqing He, Gonglie Chen, Yufan Zhang, Yan Qi, Zhongjun Wan, Lin Cai, Run Wang, Kai Wang, Dongyu Zhao, Jingzhong Zhang, Weihua Huang, Ronald X. Xu, Mingzhai Sun, Xiao Han, Yan Liu, Donghui Zhang, Wanying Zhu, Jian Liu, Yuxuan Guo   +22 more
wiley   +1 more source

Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes. [PDF]

, 2018
Serine/threonine protein phosphatase 5 (PP5) is ubiquitously expressed in eukaryotic cells; however, its function in cardiomyocytes is unknown. Under basal conditions, PP5 is autoinhibited, but enzymatic activity rises upon binding of specific factors ...
Beckendorf, Lisa, Boknik, Peter, Dos Remedios, Cris G, Gergs, Ulrich, Hamdani, Nazha, Krysiak, Judith, Linke, Wolfgang A, Redfield, Margaret M, Sheikh, Farah, Unger, Andreas, von Frieling-Salewsky, Marion   +10 more
core   +3 more sources

Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases

Cell Proliferation, EarlyView.
HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang, Yue‐Yue Wang, Ri Wen, Tie‐Ning Zhang, Ni Yang   +4 more
wiley   +1 more source

Collagen XV preserves heart function and protects from pathological remodelling after myocardial infarction

The FEBS Journal, EarlyView.
The damage caused by myocardial infarction is exacerbated in the absence of collagen XV and leads to pathological remodelling and more severe left ventricle dysfunction (left panel) compared with the wild‐type littermates. These changes are accompanied by a wide‐ranging impact, including phenotypical (middle panel) and molecular (right panel) changes ...
Sanna‐Maria Karppinen, Miki Aho, Zoltan Szabo, Johanna Magga, Laura Vainio, Erhe Gao, Paul Janmey, Lauri Eklund, Karolina Rasi, Ilkka Miinalainen, Lynn Y. Sakai, Lasse Pakanen, Heikki Huikuri, Juhani Junttila, Risto Kerkelä, Taina Pihlajaniemi   +15 more
wiley   +1 more source

Mechanobiology of muscle and myofibril morphogenesis.

Cells and Development, 2021
N. M. Luis, F. Schnorrer
semanticscholar   +1 more source

Functional Characterization of a Drosophila Transgenic Line Expressing a Chimeric Flightin: Implications on Flight Muscle Structure and Mating Behavior [PDF]

, 2015
The asynchronous, indirect flight muscles (IFM) of Drosophila are characterized by their remarkable crystalline myofilament lattice structure that has been proposed to have evolved to power skilled flight for survival, and to produce male courtship song,
Athalye, Harshal
core   +1 more source