Results 41 to 50 of about 31,768 (245)
Highly Homologous Filamin Polypeptides Have Different Distributions in Avian Slow and Fast Muscle Fibers [PDF]
, 1983 The high molecular weight actin-binding protein filamin is located at the periphery of the Z disk in the fast adult chicken pectoral muscle (Gomer, R. H., and E. Lazarides, 1981, Cell, 23: 524-532).
Gomer, Richard H., Lazarides, Elias
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Kinetic mechanism of myofibril ATPase
Biophysical Journal, 1994 The kinetic mechanism of myofibril ATPase was investigated using psoas and mixed back muscle over a range of ionic strengths. Myofibrils were labeled with pyrene iodoacetamide to measure the rate constants for the binding of ATP and formation of the weakly attached state.
Ma, Y.Z., Taylor, E.W.
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Mechanobiology of muscle and myofibril morphogenesis
Cells & Development, 2021 Muscles generate forces for animal locomotion. The contractile apparatus of muscles is the sarcomere, a highly regular array of large actin and myosin filaments linked by gigantic titin springs. During muscle development many sarcomeres assemble in series into long periodic myofibrils that mechanically connect the attached skeleton elements.
Luis, Nuno Miguel, Schnorrer, Frank
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Advanced Functional Materials, EarlyView.A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo +7 more
wiley +1 more source
Myofibril diameter is set by a finely tuned mechanism of protein oligomerization in Drosophila
eLife, 2019 Myofibrils are huge cytoskeletal assemblies embedded in the cytosol of muscle cells. They consist of arrays of sarcomeres, the smallest contractile unit of muscles.
Nicanor González-Morales +5 more
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Genetically Encoded Biosensors Reveal PKA Hyperphosphorylation on the Myofilaments in Rabbit Heart Failure [PDF]
, 2016 RATIONALE: In heart failure, myofilament proteins display abnormal phosphorylation, which contributes to contractile dysfunction. The mechanisms underlying the dysregulation of protein phosphorylation on myofilaments is not clear.
Barbagallo, Federica +15 more
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Theoretical considerations on myofibril stiffness
Biophysical Journal, 1997 A discrete model of the interaction between individual myofilaments was developed to study the stiffness of a sarcomere for the case in which filament compliance is not negligible. Our model retains, in the limit, the characteristics of the previously published model by Ford et al. (Ford, L. E., A. F. Huxley, and R. M. Simmons. 1981.
Forcinito, M., Epstein, M., Herzog, W.
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Advanced Healthcare Materials, EarlyView.This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan +12 more
wiley +1 more source
Accessibility of myofilament cysteines and effects on ATPase depend on the activation state during exposure to oxidants. [PDF]
PLoS ONE, 2013 Signaling by reactive oxygen species has emerged as a major physiological process. Due to its high metabolic rate, striated muscle is especially subject to oxidative stress, and there are multiple examples in cardiac and skeletal muscle where oxidative ...
Sean M Gross, Steven L Lehman
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Frontiers in Physiology, 2022 Myofibrillogenesis is an essential process for cardiogenesis and is closely related to excitation-contraction coupling and the maintenance of heartbeat.
Nobutoshi Ichise +9 more
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