Results 41 to 50 of about 16,958 (213)

Unconventional myosins muscle into myofibrils [PDF]

Journal of Biological Chemistry, 2019
"Myosin" is famous as a component of muscle fibrils, but the majority of myosin family members act elsewhere with roles unrelated to muscle contraction. The biological functions of a relatively new family of these unconventional myosins, myosins 18A and 18B, are poorly understood. New research from Horsthemke et al.
openaire   +3 more sources

An Implantable Phototriggered Prodrug Depot Patch Enables Actively Programmable Drug Release for Post‐Myocardial Infarction Therapy

Advanced Science, EarlyView.
An implantable phototriggered prodrug depot patch (iPDP) is presented that enables actively programmable drug release post‐implantation. Covalently conjugated prodrug ensures minimal leakage; illumination parameters serve as a code to precisely control dose per release.
Haipeng Lu, Kaicheng Deng, Zhang Zhang, Qirui Wang, Weijing Gao, Liyin Shen, Lei Zhang, Wenting Hu, Yang Zhu, Zhengwei Mao, Tanchen Ren   +10 more
wiley   +1 more source

Action of neuwiedase, a metalloproteinase isolated from Bothrops neuwiedi venom, on skeletal muscle: an ultrastructural and immunocytochemistry study

Journal of Venomous Animals and Toxins including Tropical Diseases, 2010
The damaging effects of neuwiedase, a non-hemorrhagic snake venom metalloproteinase from P-I class, on gastrocnemius muscle are studied herein. Following neuwiedase injection, ultrastructural alterations were detected early showing disarrangement of ...
C Baldo, MJ Ferreira, DS Lopes, LFM Izidoro, AO Gomes, EAV Ferro, A Hamaguchi, MI Homsi-Brandeburgo, VM Rodrigues   +8 more
doaj   +1 more source

Single‐Cell and Spatial Transcriptomics Unveil Key Regulators Governing Cell Differentiation for Schistosoma japonicum Sexual Development

Advanced Science, EarlyView.
Using single‐cell and spatial transcriptomics, we identified key regulators that govern cell differentiation involved in parasite development and egg laying in Schistosoma japonicum. This comprehensive study establishes a foundational resource for understanding schistosome biology, deciphers the regulatory programs underlying cell differentiation and ...
Zhigang Lu, Xiaoxu Wang, Shun Li, Xuxin Li, Pengfei Du, Yameng Zheng, Lu Liu, Yanyan Zhang, Omri Wurtzel, Guofeng Cheng   +9 more
wiley   +1 more source

Assembly of the giant protein projectin during myofibrillogenesis in Drosophila indirect flight muscles

BMC Cell Biology, 2004
Background Projectin is a giant modular protein of Drosophila muscles and a key component of the elastic connecting filaments (C-filaments), which are involved in stretch activation in insect Indirect Flight Muscles.
Bounaix Christophe, Ayme-Southgate Agnes, Riebe Theresa E, Southgate Richard   +3 more
doaj   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Characterization and Selection of Contractile Actuators for Soft Robotics Operating in the Quasistatic Regime

Advanced Intelligent Systems, EarlyView.
We developed methods to characterize soft contractile actuators using force–displacement measurements in the passive state and the total force in the active state and define the operational range of thermal, electrothermal, and pneumatic muscles. A graphical method enables the selection of an actuator based on the required mechanical force–displacement
Qiong Wang, Liuyang Cheng, Jeongmin Kim, Samuel Tsai, Devin Roach, Sameh Tawfick   +5 more
wiley   +1 more source

Effects of low-load resistance training with blood flow restriction on muscle fiber myofibrillar and extracellular area

Frontiers in Physiology
Blood flow restriction applied during low-load resistance training (LL-BFR) induces a similar increase in the cross-sectional area of muscle fibers (fCSA) compared to traditional high-load resistance training (HL-RT).
Cleiton A. Libardi, Joshua S. Godwin, Tanner M. Reece, Carlos Ugrinowitsch, Carlos Ugrinowitsch, Trent J. Herda, Michael D. Roberts   +6 more
doaj   +1 more source

Morphometric Analysis of Human Embryonic Stem Cell-Derived Ventricular Cardiomyocytes: Determining the Maturation State of a Population by Quantifying Parameters in Individual Cells

Stem Cells International, 2015
Quantitative methods were established to determine the level of maturation of human embryonic stem cell-derived ventricular cardiomyocytes (hESC-vCMs) that were treated with different metabolic stimulants (i.e., isoproterenol and oleic acid) during early
Harvey Y. S. Chan, Wendy Keung, Ronald A. Li, Andrew L. Miller, Sarah E. Webb   +4 more
doaj   +1 more source

Kinetic mechanism of myofibril ATPase

Biophysical Journal, 1994
The kinetic mechanism of myofibril ATPase was investigated using psoas and mixed back muscle over a range of ionic strengths. Myofibrils were labeled with pyrene iodoacetamide to measure the rate constants for the binding of ATP and formation of the weakly attached state.
Ma, Y.Z., Taylor, E.W.
openaire   +2 more sources