Results 41 to 50 of about 21,463 (243)

Effects of Chronic Atrial Fibrillation on Active and Passive Force Generation in Human Atrial Myofibrils

, 2010
Rationale: Chronic atrial fibrillation (cAF) is associated with atrial contractile dysfunction. Sarcomere remodeling may contribute to this contractile disorder.
Piroddi, N., FERRANTINI C, PIRODDI N, Mugelli, A., Toniolo, L., MEARINI G, VAN DER VELDEN J, Cerbai, E., BELUS A, Cazorla, Olivier, Rossi, A., DROST M, POGGESI C., Mearini, G., TESI C, MUGELLI A, CARRIER L, Belus, A., ROSSI A, Drost, M., TONIOLO, LUANA, CERBAI E, Ferrantini, C., Tesi, C., Poggesi, C., Carrier, L., CAZORLA O, Belus, Alexandra Anna Sophie, Ferrantini, Cecilia, Cerbai, Elisabetta, Tesi, Chiara, Mugelli, Alessandro, Piroddi, Nicoletta, Poggesi, Corrado, van Der Velden, J.   +34 more
core   +1 more source

Myofibrils put the squeeze on nuclei [PDF]

Nature Cell Biology, 2017
During muscle development, nuclei travel from the centre of the myofibre to the periphery, a process defective in certain diseases. A new study reveals that this movement is due to centripetal forces imposed on nuclei by the crosslinking and contraction of myofibrils.
Jonathan N, Rosen, Mary K, Baylies
openaire   +2 more sources

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

Accessibility of myofilament cysteines and effects on ATPase depend on the activation state during exposure to oxidants. [PDF]

PLoS ONE, 2013
Signaling by reactive oxygen species has emerged as a major physiological process. Due to its high metabolic rate, striated muscle is especially subject to oxidative stress, and there are multiple examples in cardiac and skeletal muscle where oxidative ...
Sean M Gross, Steven L Lehman
doaj   +1 more source

The VCPIP1‐UBE3A Deubiquitination‐Ubiquitination Cascade Contributes to Castration‐Resistant Prostate Cancer Progression

Advanced Science, EarlyView.
VCIPIP1 emerges as a molecular link between protein stability and prostate cancer progression. By deubiquitinating and stabilizing UBE3A, VCIPIP1 promotes p53 degradation and progression to castration‐resistant prostate cancer. Elevated VCIPIP1 expression is associated with shorter castration‐resistant prostate cancer–free survival, highlighting the ...
Fei Lin, Wen‐Cai Zheng, Yi‐Qiu Wang, Bin Lin, Yun‐Zhi Lin, Dong‐Ning Chen, Xiao‐Dong Li, Xue‐Yi Xue, Yong Wei, Ning Xu   +9 more
wiley   +1 more source

Gaining new understanding of sarcomere length non-uniformities in skeletal muscles

Frontiers in Physiology
Sarcomere lengths are non-uniform on all structural levels of mammalian skeletal muscle. These non-uniformities have been associated with a variety of mechanical properties, including residual force enhancement and depression, creep, increased force ...
Meng Li, T. R. Leonard, S. W. Han, E. K. Moo, E. K. Moo, E. K. Moo, W. Herzog   +6 more
doaj   +1 more source

GAP43 is localized around the myofibrils and alternates to mitochondria.

, 2013
A-C) Immuno-fluorescence of transverse sections stained with anti-GAP43 antibody, shows a reticular pattern surrounding myofibrils, quite similar to that formed by mitochondria (marked by TOM20).
Raffaele Pilla (105233), Cecilia Paolini (105226), Giorgio Fanò-Illic (105237), Maria A. Mariggiò (105241), Caterina Morabito (105223), Simone Guarnieri (105220), Simona Boncompagni (105229)   +6 more
core   +1 more source

Cardiac morphological and morphometric analysis of Ardea alba

The Anatomical Record, EarlyView.
Abstract Ardea alba (Linnaeus, 1758) is a widely distributed heron species whose cardiovascular morphology remains poorly described. This study aimed to characterize the cardiac morphology and morphometry of adult A. alba. Ten specimens were analyzed using radiographic, morphometric, histological, scanning electron microscopy, and three‐dimensional ...
Julia Vaz Feio, Max Alex Santos Ferreira, Elane Guerreiro Giese, Érika Branco, Antônio Basílio Guerreiro Junior, Ana Rita de Lima   +5 more
wiley   +1 more source

Ultrastructural Assessment and Proteomic Analysis in Myofibrillogenesis in the Heart Primordium After Heartbeat Initiation in Rats

Frontiers in Physiology, 2022
Myofibrillogenesis is an essential process for cardiogenesis and is closely related to excitation-contraction coupling and the maintenance of heartbeat.
Nobutoshi Ichise, Tatsuya Sato, Tatsuya Sato, Hiroyori Fusagawa, Hiroyori Fusagawa, Hiroya Yamazaki, Taiki Kudo, Izaya Ogon, Izaya Ogon, Noritsugu Tohse   +9 more
doaj   +1 more source