Results 31 to 40 of about 19,828 (252)
, 2014 M.B. was funded by a Wellcome Trust Senior Investigator Award to P. Lawrence (WT096645MA).Muscle differentiation requires the assembly of high-order structures called myofibrils, composed of sarcomeres.
Estrada, B +3 more
core +1 more source
eLife, 2023 Sarcomeres are the basic contractile units within cardiac myocytes, and the collective shortening of sarcomeres aligned along myofibrils generates the force driving the heartbeat.
Abigail C Neininger-Castro +7 more
doaj +1 more source
Myofibrils of skeletal muscle: the activity coefficient of orthophosphate.
, 1997 In the myofibrils of skeletal muscle, at 22°C, pH 7.1 and at the physiological protein osmotic pressure of 1.8 x 105 dynes/cm2, orthophosphate behaves quite ideally, the activity coefficient being 0.85.
MAGRI E. +4 more
core +3 more sources
Myofibrils put the squeeze on nuclei [PDF]
Nature Cell Biology, 2017 During muscle development, nuclei travel from the centre of the myofibre to the periphery, a process defective in certain diseases. A new study reveals that this movement is due to centripetal forces imposed on nuclei by the crosslinking and contraction of myofibrils.
Jonathan N, Rosen, Mary K, Baylies
openaire +2 more sources
Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach +23 more
wiley +1 more source
Myofibril diameter is set by a finely tuned mechanism of protein oligomerization in Drosophila
eLife, 2019 Myofibrils are huge cytoskeletal assemblies embedded in the cytosol of muscle cells. They consist of arrays of sarcomeres, the smallest contractile unit of muscles.
Nicanor González-Morales +5 more
doaj +1 more source
Advanced Functional Materials, EarlyView.A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo +7 more
wiley +1 more source
Contractile Properties of Human Fetal Skeletal Myofibrils
, 2013 Congenital contractures such as clubfoot are present in ?1/250 live births. Several congenital contractures syndromes are caused by mutations in genes that code for skeletal myofilament proteins, including MYH3 and MYH8.
Regnier, Michael +4 more
core +1 more source
Accessibility of myofilament cysteines and effects on ATPase depend on the activation state during exposure to oxidants. [PDF]
PLoS ONE, 2013 Signaling by reactive oxygen species has emerged as a major physiological process. Due to its high metabolic rate, striated muscle is especially subject to oxidative stress, and there are multiple examples in cardiac and skeletal muscle where oxidative ...
Sean M Gross, Steven L Lehman
doaj +1 more source
Frontiers in Physiology, 2022 Myofibrillogenesis is an essential process for cardiogenesis and is closely related to excitation-contraction coupling and the maintenance of heartbeat.
Nobutoshi Ichise +9 more
doaj +1 more source